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A recent study reports that obesity is linked to late-onset psoriasis and psoriatic arthritis (PsA). By contrast being of normal weight may be associated with an earlier onset of the disease adn HLA-B27.
Patients with early PsA were compared to those without arthritis (PsC), with regard to their body mass index (BMI) and HLA risk alleles for psoriatic disease (HLA-B*27, B*3901, B*3801, B*0801, B*4402, B*4403, and C*0602). A case-controlled designed was utilized to detect associations.
Obesity was more common among the 314 patients with early PsA compared to 498 PsC patients (OR 1.77; p = 0.002).
Higher BMI was significantly associated with older age at onset for both PsA and psoriasis (p = 0.009).
HLA-B*27 was higher in patients with normal weight compared with those with higher BMI (p = 0.002).
Body weight significantly influences the onset and expression of psoriatic disease.