Tuesday, 20 Mar 2018

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Obesity Associated with Late-Onset Psoriatic Arthritis

A recent study reports that obesity is linked to late-onset psoriasis and psoriatic arthritis (PsA).  By contrast being of normal weight may be associated with an earlier onset of the disease adn HLA-B27.

Patients with early PsA were compared to those without arthritis (PsC), with regard to their body mass index (BMI) and HLA risk alleles for psoriatic disease (HLA-B*27, B*3901, B*3801, B*0801, B*4402, B*4403, and C*0602). A case-controlled designed was utilized to detect associations. 

Obesity was more common among the 314 patients with early PsA compared to 498 PsC patients (OR 1.77; p = 0.002).

Higher BMI was significantly associated with older age at onset for both PsA and psoriasis (p =  0.009).

HLA-B*27 was higher in patients with normal weight compared with those with higher BMI (p = 0.002).

Body weight significantly influences the onset and expression of psoriatic disease.

The author has no conflicts of interest to disclose related to this subject

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