Friday, 18 Oct 2019

You are here

P. Gingivalis Antibodies Antedate Rheumatoid Arthritis Onset

Periodontal disease, gingivitis and Porphyromonas gingivalis have been linked to the pathogenesis of rheumatoid arthritis (RA) and the production of anti-citrullinated protein antibodies (ACPA).

Researchers from Sweden have sudied if anti-P. gingivalis antibodies antedate RA symptom onset and ACPA production.

They identified 251 RA cases and 198 controls who had banked blood samples before the onset of RA symptoms by 5.2 years  Samples were analyzed for antibodies to P. gingivalis virulence factor arginine gingipainB (RgpB), and a citrullinated peptide (CPP3) derived from the P. gingivalis peptidylarginine deiminase enzyme.

They found significantly high antibody levels against P. gingivalis that were present years before onset of symptoms of RA; thereby  supporting an etiological role for P. gingivalis in RA.

Anti-CPP3 antibodies followed the ACPA response, with increasing concentrations over time, whilst anti-RgpB (P. gingivalis) antibodies were elevated and stable in the pre-symptomatic individuals with a trend towards lower levels after the diagnosis of RA.

The author has no conflicts of interest to disclose related to this subject

Add new comment

More Like This

Stress and the Risk of Incident Inflammatory Arthritis

A prospective analysis of newly diagnosed, inflammatory arthritis (IA) patients suggests that perceived distress (stress) increases the odds of incident IA.

Juvenile Arthritis at Risk for Coronary Artery Disease

Arthritis Care & Research reports that juvenile arthritis (JA) patients may have a higher risk if coronary artery disease (CAD) in adulthood. 

Data was drawn from the National Health and Nutrition Examination (2007‐2014).  The diagnoses of JA and CAD were self declared by respondents.

Long Delays for Inflammatory Arthritis Patients

The National Rheumatoid Arthritis Society's (NRAS) annual audit has identified significant treatment delays for patients with suspected early inflammatory arthritis could result in unnecessary harm. 

Antibiotics Increase Rheumatoid Risk - Again

Another UK study has suggested that prior use of antibiotics increases the risk of developing rheumatoid arthritis (RA).

Rheumatology has published a 15 year case–control study that compared 8482 newly diagnosed RA patients and 22,661 controls from the UK’s Royal College of General Practitioners Research and Surveillance Centre database (between 2006 and 2018).

Two vs. Four Weeks of Antibiotic Therapy in Septic Arthritis

A prospective trial has shown that 2 weeks of antibiotic therapy is as effective as 4 weeks of antibiotic therapy, with similar outcomes but shorter hospital stays.

This Swiss study was a prospective, unblinded, randomised, non-inferiority study comparing either 2 or 4 weeks of antibiotic therapy after surgical drainage of native joint bacterial arthritis in adults.