Tuesday, 23 Jan 2018

You are here

Potential Reasons Why Osteoarthritis Preferentially Affects Women

Researchers from Augusta University have examined exosomes from patients with knee osteoarthritis (OA) to enhance our molecular understanding of the pathogenesis of OA. (Citation source http://buff.ly/2tuDZ3v)

Exosomes play a vital role in cell-to-cell communication. By obtaining samples from OA patient synovial fluid, researchers analyzed the exosomes that carry microRNAs (miRNAs) that regulate gene expression. Their supposition was that molecular profiling of synovial fluid derived exosomal miRNAs may increase the understanding of OA progression.

They found distinct differences in miRNA activity between men and women with OA.  Interesting, in light of the fact that OA is more common in women than men; the reasons for which are unknown.

The synovial fluid of men showed 69 downregulated and 45 upregulated miRNAs, while in women there were 91 downregulated and 53 upregulated miRNAs.

Women were more likely than men to show a deactivation or alteration of miRNAs that are important for estrogen signaling and collagen production.

Thus the loss of estrogen levels during menopausal years may be associated with an increased risk of OA. It has been previously noted that women on hormone replacement therapy have a lower risk of OA.

One potential use of this stems from their efforts showing that blocking estrogen availability in exosomes using aromatase inhibitors may lead to a reduction in miRNAs.

The study also disclosed that one particular miRNA, called MiR-504-3p, was upregulated in both men and women with OA. The significance of this is unknown but may related to cartilage degeneration. 

Disclosures: 
The author has no conflicts of interest to disclose related to this subject

Add new comment

More Like This

Two Types of Osteoarthritis Based on Cartilage Studies

A report from Annals of Rheumatic Diseases suggests that osteoarthritis (OA) may be two distinct diseases based on genetic studies of articular cartilage. (Citation source: https://buff.ly/2mNtUsL).

RNA sequencing of knee cartilage from 44 OA patients undergoing total knee replacement was compared to 6 additional patients with OA and 10 control patients with non-OA.

New Rise in Hip Fractures Amongst Women

Reuters reports that the incidence of hip fractures in older women in the U.S. is rising after more than a decade of decline, according to a large new study of Medicare recipients.

Calcium and Vitamin D Supplements Do Not Reduce Hip Fractures

Recent JAMA study shows metanalysis of 33 clinical trials and 51,145 participants, showed that calcium, vitamin D, or both affords no decreased risk of hip fractures compared with placebo or no treatment and therefore questions their routine widespread use in the elderly.. 

Community Screening for Fracture Risk in Older Women is Effective and Feasible

A UK Study published in Lancet shows that community-based screening programme for fracture risk in older women is feasible, and may reduce hip fractures. 

Older women, age 70-85 yrs, were identified and participated in the trial and were assessed using the Fracture Risk Assessment Tool (FRAX) with usual management. 12 483 were enrolled and 6233 women randomly assigned to the screening group.

Knee Surgery Outcomes Worse with Low Education

Reuters reports that patients who live in low-income communities and lack a college education may have worse pain after knee replacement surgery than their more educated neighbors, citing results from a recent study from the Hospital for Special Surgery in NY.