Monday, 27 Jan 2020

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RheumNow Podcast – Antibiotics Increase RA Risk (8.16.19)

Dr. Jack Cush reports the news and important journal articles from the past week on

  1. Nurses' Health Study II shows high gluten intake is not assoc with a greater risk of Psoriasis (HR 1.15;0.98-1.36), Psoriatic arthritis (HR 1.12;0.78-1.62) or Atopic dermatitis (HR 0.91; 0.66-1.25); data frin 85,185 Pso, 85,324 PsA and 63,443 atopic dermatitis patients.   
  2. Cross sectional analysis of ~3000 and meta-analysis (14 studies) finds #gout has a higher risk of hypothyroidism, esp in female gout pts (OR=2.44;1.15-5.17); Metaanalysis shows an increased risk hypothyroidism in gout (OR=1.51) and hyperuricemic pts (OR=1.34) 
  3. Lilly announces the results of its phase 4 trial comparing Taltz (IL-17) to Tremfya (IL-23) in mod-severe plaque psoriasis. Taltz had superior skin clearance (PASI 100) at week 12, better PASI 75 at week 2 and PASI 90 at weeks 4 and 8.  
  4. In GCA/Temporal arteritis, when do you start a DMARD/Biologic as a steroid sparing Rx?  
  5. Do we care about opioids?  Nearly 30% of presurgical OA (Spine> Hip & Knee) used prescription opioids. Opioid use was greater with spine OA (vs. knee OA), obesity, smokers, depression, greater pain, higher TJC, and concurrent use of other pain meds 
  6. Case-control study using the UK Clinical Practice Research database examined 22,677 RA patients 1995–2017) exposed to antibiotics vs. ~90K controls shows the risk of RA is 60% higher if Abx exposed (OR 1.60; 95% CI 1.51–1.68) – is this from microbiome changes?
  7. RA Disease Activity Drives Lung Complications  
  8. Enbrel Patent Battle Won by Amgen  
  9. "WAR on RA - Part 4: Desperado" is featured on RheumNow. Why the Eagles and Glenn Fry's death should inspire us to better, greater, more and other superlatives in RA. 
  10. Trends in Inflammatory Arthritis Care in Germany  


The author has received compensation as an advisor or consultant on this subject

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