Monday, 09 Dec 2019

You are here

RheumNow Week in Review – 4 November 2016

Dr. Jack Cush reviews highlights and reports from this week on, including drug-induced cutaneous lupus, pediatric lupus being worse, new gout drug SEL-12, Gut microbiome and IgA plasmablasts, and the weakly-received new ACP guidelines on gout.

  1. Drug induced cutaneous lupus 88 pts reviewed: most common PPIs, thiazide, antifungals, chemoRx, statins, epileptics
  2. 9 of 10 US physicians surveyed said they'd consider switching a patient from an originator biologic to a biosimilar
  3. Pyoderma gangrenosum (PG) part of other pustular autoinflammatory diseases; PAPA, SAPHO, PASH (PG, acne, hydradenitis)
  4. Juvenile vs adult SLE compared: JSLE is worse w/ more renal, alopecia, oral ulcers, heme, CNS, autoAbs, mortality
  5. Rare reports of tocilizumab related pancreatitis, etiology unclear. Most begin as acute pancreatitis.
  6. Review of pregnancy & lactation says there is insufficient data on RTX, ABA, Kineret, TCZ, Tofa, Stelara, and Benlysta to be used in Pregnancy.
  7. SEL-12 entering Ph 2 trials in gout; a nonimmunogenic pegsiticase (pegylated uricase) combined with SVP-Rapamycin.
  8. Interesting 2 cases of lupus nephritis (Bx Class III & V) onset AFTER 2-3 mos belimumab Rx -wrong drug or too late?
  9. Prevalence of Inflammatory Bowel Disease Increased from 1.8 (1999) to 3.1 million (2015) 
  10. WSJ article on When Cheap Generics Morph into Expensive Prescriptions. Combo drugs like Duexis and Vimovo cost nearly $2000
  11. IgA ACPA and Plasmablasts Point to Microbiome in Pre-Clinical Rheumatoid
  12. Decreased CD4 T Cells with Rituximab Infusions
  13. ACP Gout Guidelines Reviewed and Critiqued by Rheumatologists

The author has received research/grant financial support on this subject
The author has received compensation as an advisor or consultant on this subject

Add new comment

More Like This

RheumNow Podcast - Monitoring Methotrexate Safety (12-6-19)

Dr. Jack Cush reviews the news and journal reports from the past week on

#WomenInRheumatology: Is There a Speaker Gender Gap at ACR Meetings?

Recent studies have quantified the gender gap among speakers at academic conferences. The largest study of 181 medical conferences held in North America over one decade found an increase in the proportion of female speakers from 25 to 34% over time, and that the underrepresentation of women was more marked at surgical compared to medical conferences.

RheumNow Podcast –Favorites of ACR 2019 (11.22.19)

Dr. Jack Cush recaps standout presentations and information from ACR 2019 held in Atlanta November 9-12, 2019.

Hepatitis C-Related Cryoglobulinemic Vasculitis

Flares of vasculitis can still be a problem after hepatitis C-related cryoglobulinemic vasculitis patients are cured of their hepatitis C by direct-acting antivirals, as demonstrated by data from four registries presented at ACR 2019 in Atlanta, Georgia.

ACR 2019 - Report from Day One (Sunday)

Sunday was the first full day of scientific sessions at the 2019 ACR/ARP meeting in Atlanta. Yesterday we shared our initial news articles, videos and more with you. Following is my roundup of day one. 

Delays in Diagnosis