Friday, 13 Sep 2019

You are here

RheumNow Week in Review – 9 December 2016

Dr. Jack Cush reviews highlights from this week on

  1. RA pts have 2 fold CV risk (equal to DM related risks). Shouldnt Rheums be responsible for managing CV risk in RA
  2. Smoking in non-RA not associated with Autoantibodies; but in RA, smoking is associated with multiple autoantibodies (RF, CCP2, CarP)
  3. Tumor-induced osteomalacia, rare, with low serum phosphate, high Alkaline phosphatase, fatigue arthralgias, multiple fractures from FGF-23 producing mesenchymal tumors.
  4. PFAPA syndrome in Adults too: Periodic Fevers (q4wk), Aphthous ulcers , Pharynbitis, Cervical Adenitis, arthralgias, myalgia, N/V, abdominal pains.
  5. Genes/SNPs that influence RA onset/risk are not predictive of drug responses or ultimate outcomes
  6. 10% of ANCA+ vasculitis developed cancer; CTX had 3x risk (vs. normals); RTX had 33% lower risk. Cancer was 4.6x more with CTX than RTX
  7. BMJ study of >19k men, shows testosterone use associated with a 63% increased risk of DVT in the 1st 6mos.
  8. TAFRO syndrome: a rare inflammatory disorder with thrombocytopenia, anasarca, pleural effusion, ascites, fever; renal insufficiency, organomegaly, lymphadenopathy
  9. Catastrophic antiphospholipid registry of 500 patients: 30% had SLE, death in 37%; renal 73%, lung 60%, half w/ CNS, heart, skin
  10. ENTRACTE study shows an equal CV Risk with Actemra vs Enbrel in RA patients
  11. Key Lessons from the TNF Inhibitor Head-to-Head EXXELERATE Study
  12. Is ABT-494 the Next JAK Inhibitor?

The author has received research/grant financial support on this subject
The author has received compensation as an advisor or consultant on this subject

Add new comment

More Like This

RheumNow Podcast – The End of Arthritis (9.13.19)

Dr. Jack Cush reviews the news and journal articles from the past week on

RheumNow Podcast – Do’s and Don’ts in Spondylitis (9.5.19)

Dr. Jack Cush reviews the news and important research published in the last two weeks on

Influenza Vaccination Update

FDA's Vaccines and Related Biological Products Advisory Committee met in Silver Spring, Maryland, on March 6 and 22, 2019, to select the influenza viruses for the composition of the influenza vaccine for the 2019-2020 U.S. influenza season.

RheumNow Podcast - I Wanna New Drug (8-30-19)

Dr. Jack Cush vents on choosing new therapies in rheumatoid arthritis.

RheumNow Podcast – Upadacitinib FDA Approved for RA (8.23.19)

Dr. Jack Cush reports on the news and journal reports from the past week on, including: how your genetics may shape your microbiome; GERD as a risk factor for TMJ?; how can MDA-5+ dermatomyositis be any worse; new drug happenings;; and more.