Wednesday, 12 Dec 2018

You are here

The RheumNow Week in Review – Life Savers for Rheumatologists (6.29.18)

Dr. Jack Cush reviews selected news and journal reports from the past week on RheumNow.com.

  1. European Commission has approved XELJANZ® (tofacitinib citrate) 5 mg twice daily (BID) in combination with methotrexate (MTX) for the treatment of adults with active psoriatic arthritis (PsA) with an inadequate response to DMARDs https://t.co/G6YYXSuUyQ
  2. Study of 14 EGPA pts shows mean age 12.3 yrs, All w/ Lung, upper airway (85%), skin (71%), GI tract (64%), heart (57%). CNS & renal Dz were rare. Only 31% ANCA+. Compared to adult, kids have more ENT, CV, & GI. https://t.co/v1wwrTUgsT 
  3. MPO (myeloperoxidase) Abs(MPO-ANCA, pANCA) may be associated with a wider variety - GPA, EGPA, microscopic polyangiitis, Goodpastures, PAN, glomerulonephritis, lupus, interstitial lung dz, bronchiectasis, alveolar hemorrhage, RA, IBD, autoimmune liver dz https://t.co/cWb0UeOu0h 
  4. TMP/SMX prophylaxis following rituximab in ANCA+ associated vasculitis reduces infections by 70% (HR 0.30) - 192 AAV pts with 92 infx in 49 pts (only 1 due to PJP). https://t.co/VmVDXQqlSZ 
  5. Taiwan claims analysis of #RA patients shows that despite low rates (10-20%) of influenza vaccination, those vaccinated had a significant ~35% lower rate of death and hospitalization (sepsis, bacteremia, viremia) https://t.co/Y17d66AZnC
  6. HCQ use in Lupus associated with 32% lower risk of all cause mortality at 1 yr. (a Taiwan claims data study of 2287 #SLE patients either on or off plaquenil) https://t.co/qt4nFcYCQw
  7. The risk of psoriatic arthritis in psoriasis is 23.8% according to a systematic review and metanalysis in JAAD (using CASPAR criteria). The incidence of PsA in psoriasis ranged from 0.27-2.7/100PY https://t.co/tnw41vFQe3   
  8. Study of 20,000+ patients receiving knee or hip replacements finds that, compared to OA, #RA patients have a high risk of post-op MI (HZ 3.54) and more revision surgeries (HZ 1.61)over 10 yrs https://t.co/YXH5FqHnr0 
  9. Public Citizen Pressures FDA to Pull Febuxostat   
  10. Ixekizumab Effective in Ankylosing Spondylitis 
Disclosures: 
The author has received compensation as an advisor or consultant on this subject

Add new comment

More Like This

RheumNow Podcast – Can RA Be Prevented (12.7.18)

Dr. Jack Cush reviews the news and new journal articles from the past week on RheumNow.com:

Chronic Kidney Disease Increasing in the U.S.A.

JAMA has published the Global Burden of Disease (GBD) study showing that that, from 2002 to 2016, the US burden of chronic kidney disease (CKD) increased, with some states exhibiting more than twice the burden as others. The increase in burden was associated with increased metabolic and dietary risk exposure that manifested in increased probability of death due to diabetic CKD, especially for those between 20 to 55 years.  

RheumNow Podcast – To Needle or Not to Needle (11.30.18)

Dr. Jack Cush updates the news and reports from the past week at RheumNow.com:

Physical Activity Guidelines for Americans

The data are clear and disappointing: despite the well-known health benefits, four out of five US adults are not active physically.  JAMA has published the new US Physical Activity Guidelines for Americans, so that health professionals and policy makers can promote lifestyle changes and awareness of the the health benefits of physical activity.

The RheumNow Podcast – Heartbreak of Methotrexate (11.16.18)

Dr. Jack Cush reviews the news from the past week at RheumNow.com.