Friday, 17 Aug 2018

You are here

The RheumNow Week in Review – Vitamin D Snark Report (4.20.18)

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com.  A second life for Syk kinase, Vitamin D talk, VTE, regulatory hearings and the Lupus clinic edge.

  1. Fostamatinib, a spleen tyrosine kinase (Syk)inhibitor, that failed in #RA, has been FDA approved for use in adult with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment. The drug will be called Tavalisse. http://bit.ly/2K2zpyG
  2. ACTIVExtend study shows that 9mos of abaloparatide followed by 2 yrs of alendronate is better for BMD and Fx rates than abaloparatide or alendronate alone. https://t.co/amYAsxnwhe
  3. Medscapes annual report on MD salararies shows a pay increased of 9% to $257,000 (the range in change was +16% to a -9% for general surgeons). https://t.co/TN70M3nn0K
  4. IGRA are specific for M.Tbc but there are few NTM (nontuberculous mycobacteria) that can give a +QFT; M. Bovis, M. Africans, M. kansasii, M.Szulgai, M. marinum, M.gordonae. These have ESAT & CFP Ags. https://t.co/yFWsCb5ncT
  5. 2996 HIV+ patients on HRT finds 113 w/ Rheumatic disease, lead by AVN 39 (1.3%), psoriasis 28 (1%), RA 7, PsA 6, & SLE 6pts. HIV Males 1.7 times more likely to have a rheum Dz. Hep C incr the risk of RD. RD Risk in HIV+ appears same as gen population. https://t.co/32PiLEeKgI
  6. Lupus care provided by a Lupus specialty vs General Rheumatology (GRC) shows LC w/ better quality measures [86% vs 70%] w/ better APL testing, DXA, steroid sparing , ACE inhibitor use Moderate correlation between the MDs #SLE patients and QM performance https://t.co/HeHZgkA0Gv
  7. Study of 1181 Systemic Sclerosis pts finds 3.4% w/ hx of VTE events= VTE incidence of 2.7 per 1000 pt-yrs (equal to general population). Risk factors for VTE were PAH, peripheral arterial disease, Scl-70+, anticardiolipin Abs (OR 2.45-5.7) https://t.co/AgBb7tGvGh
  8. What drives VTE risk in Rheumatology Clinic? Surgery, inflammation, obesiy, smoking, drugs or Cancer? RHEUMS ONLY vote here--> https://t.co/rmilEeZthL
  9. EMA will have a hearing on June 13th on the safety of quinolones. https://t.co/14r8fQtpcB 
  10. OMI! Low Vitamin D is ALSO associated with an increase risk of noninfectious uveitis, primarily in blacks - if only giving vitamin D could fix the disease its associated with ! https://t.co/Ao41s8YHjG
  11. UNBELIEVABLE. NEWS FLASH.. Vitamin D again linked to something, this time a greater risk of diabetes. Take the vitamin D and a few marshmallows. http://bit.ly/2HfjGue
  12. USPSTF Recommendations on Vitamin D, Calcium Supplementation to Prevent Fractures  
  13. Kineret Approved for Still's Disease in EU 
  14. Shared Epitope - Smoking Pathogenic Link Clarified  

 

Disclosures: 
The author has received compensation as an advisor or consultant on this subject

Rheumatologists' Comments

Fantastic ! Thanks for these short news of rheumatology relavent .I have a question : can Osteoporosis be regarded as an autoimmune disease ? Because in on study at HIV -infected patients after 48 wks Treatment with ART regimen despite decline of BMD &TBS , BMSi measured by Osteoprobe (RPI Technology )increased by 7% !
Fantastic ! Thanks for these short news of rheumatology relavent .I have a question : can Osteoporosis be regarded as an autoimmune disease ? Because in one study on the HIV -infected patients after 48 wks Treatment with ART regimen despite decline of BMD &TBS , BMSi measured by Osteoprobe (RPI Technology )increased by 7% !

More Like This

ACR Meets With HHS Secretary Azar to Discuss Step Therapy Concerns

Yesterday, the American College of Rheumatology (ACR) met with U.S. Department of Health and Human Services Secretary Alex Azar for a productive discussion about the rheumatology community's concerns with a new policy that will allow Medicare Advantage plans to utilize step therapy in Medicare Part B. In the meeting, the ACR expressed concerns that this policy would delay rheumatology patients' access to treatments.

The RheumNow Week in Review – We’re Number One! (8.17.18)

Dr. Cush reviews the articles and news from the last week on RheumNow.com. Information on comorbidities, the downside of steroids, unmet need in psoriatic arthritis, and the top 10 rheumatology programs.

U.S. News 2018-19 Rheumatology Rankings

The Annual U.S. News and World Report Rankings of Hospitals has listed the top contenders in the field of rheumatology. The U.S. News Review rates hospitals nationwide in 16 specialties – including rheumatology. Of the 4,500 hospitals covered by U.S. News that were analyzed, 158 were classified nationally in at least one specialty area.

The RheumNow Week in Review – No Good Gout (8.10.18)

Dr. Jack Cush reviews the news and latest journal articles from the past week on RheumNow.com. Info on Surgery and Hip Fractures, Gout drugs abandoned, Allopurinol escalation, hydroxychloroquine drug levels, how to treat scleroderma in India and exactly who gets back pain.

The RheumNow Week in Review – Handshakes or Hugs (8.3.18)

Dr. Jack Cush reviews the news and highlights from the past week on RheumNow.com, including new treatments for LTBI, gout consequences, RA and offspring risk, PsA risk, and the opioid epidemic effects.