Wednesday, 25 Apr 2018

You are here

The RheumNow Week in Review - 12 January 2018

Dr. Jack Cush reviews a dozen highlights from the past week on RheumNow.com.

  1. Study of THR in Hip arthritis patients shows that Surgeons who do "overlapping surgeries" (supervises 2+ operations simultaneously) have a 90% in surgical complications in 1st yr. https://t.co/E8pQY2S1jg 
  2. Metanalysis of the RA cost of care (12 papers, only1/3 good) shows Total direct medical costs to be ~ $12,509 for all RA pts; $36,053 for bDMARD users; RA-specific costs were $3,723 all RA patients and $20K for bDMARD users https://t.co/JYzgrUgnfF
  3. DMARD Tip: Leflunomide has a drug 1/2 life of nearly 20 days. Once pt improved w/ 20mg/d (~6-12 wks) I switch dosing to once weekly, often less total mg (eg, LEF 4-6 tab q friday (80-120mg/wk). Monitoring and risks are same. https://t.co/dP7EooQEKz
  4. 8,534 FMF Israeli patients were found to have a lower risk of Cancer (SIR 0.66;(95% CI 0.55–0.77). The question: is: inflammation-related Cancer risk different with disorders of adaptive vs innate immunity? https://t.co/s5iFYhmvhF
  5. Krystexxa annual sales expected to increase from $400 million to $750 million. Horizon reports the number of gout patients treated increased from 50,000 to 100,000. https://t.co/sPTf8UueVc
  6. Swedish study of 331,941 construction workers (31 years F/U): 1,623 had lumbar spinal stenosis surgery, with rates highest in those who were heavy smokers https://t.co/XNbLYdARjc
  7. Gabapentinoid use steadily rose from 1.2% of adults in 2002 to 3.9% in 2015 https://t.co/seC0thDIX9
  8. Study of ~300k Canadian pregnancies (1998-2015) finds 51 LEF patients with 1st Trimester exposures to Arava & 21 patients with 2nd/3rd Tri exposure; Find no incr risk of spont Abortion (11), Malformations (5), prematurity (7) or LBW (8) https://t.co/jsVXdvQGEM
  9. B Cell Changes Predict Autoimmunity with Checkpoint Inhibitors   
  10. 40% of Arthritis Patients Fail to Receive Exercise Guidance  
  11. Increasing Adverse Events Seen with Higher Disease Activity in Early RA
  12. Calcium and Vitamin D Supplements Do Not Reduce Hip Fractures 

 

Disclosures: 
The author has received compensation as an advisor or consultant on this subject

Add new comment

More Like This

The RheumNow Week in Review – Vitamin D Snark Report (4.20.18)

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com.  A second life for Syk kinase, Vitamin D talk, VTE, regulatory hearings and the Lupus clinic edge.

RheumNow Week in Review - Do you Dig Shingrix? (4.6.2018)

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. Highlights includes manpower shortfalls, comorbidities in AA Lupus, certolizumab pregnancy safety, which Shingles vaccine is best and the power of combination biologics in severe refractory  SLE.

"Breakthrough" Drug Designation by the FDA

The current issue of the NEJM reviews the Food and Drug Administration (FDA) “breakthrough therapy” designation that was introduced in 2012 to expedite testing and approval of medications that were intended to treat serious or life-threatening conditions.  This status is granted when preliminary evidence with a new drug suggests substantial benefits over existing therapies for these unfortunate conditions.

ACR Projects Significant Manpower Shortages for 2030

Arthritis & Rheumatology has published the results of the 2015 Workforce Study of Rheumatology Specialists, and estimates a current shortage (demand > supply) of 700 (12.9%) full-time rheumatologists and that this deficit will worsen (102%) to 4133 FTE by 2030.

RheumNow Week in Review -The Temporal Artery Biopsy Letdown (4.6.2018)

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. News on the cost of RA care, infections on planes, CV events and Sacroiliitis in IBD, NXP-2 antibodies and calcinosis and rituximab in myositis ILD patients.