Tuesday, 20 Mar 2018

You are here

Rituximab Efficacy in IgG4 Related Disease

PLOS reports  greater than 90% efficacy when rituximab (RTX) is used to treat patients with IgG4-related disease (IgG4-RD). 

The diagnosis and management of IgG4-RD is challenging and often without proven trial-based evidence.  A French national retrospective multicenter study examined the efficacy of RTX given to 33 patients with IgG4-RD. This RTX treated cohort was drawn from a total of 156 IgG4-RD patients in the French database.

A clinical response was noted in nearly all patients - 29/31 (93.5%) improved and steroid withdrawal was achieved in over half the patients (51.5%).

During a mean follow-up of 24 months, 13/31 (41.9%) of the RTX responding patients relapsed a mean of 19 months after RTX. 

Patients with active disease (IgG4-RD Responder Index >9) before RTX were more likely to relapse (HR = 3.68, 95% CI: 1.1, 12.6) (P = 0.04), whereas maintenance RTX therapy was associated with longer relapse-free survival (41 versus 21 months; P = 0.02). 

Important adverse effects included 8 serious infections in 4 patients (rate = 12.1/100 patient-years) and hypogammaglobulinemia was seen in 3 patients.

RTX is effective for both induction and maintenance therapy for IgG4-RD, but relapses are frequent after B-cell reconstitution. 

The author has no conflicts of interest to disclose related to this subject

Add new comment

More Like This

FDA Panel Votes to Favor High Dose Xeljanz in Ulcerative Colitis

Yesterday a FDA advisory panel voted 15-0 in favor of approving Xeljanz (tofacitinib) 10 mg bid for patients with moderate to severe ulcerative colitis.

The US Food and Drug Administration’s (FDA) convened the Gastrointestinal Drugs Advisory Committee Meeting (GIDAC) to assess Pfizers supplemental new drug application for tofacitinib in adult patients with moderately to severely active ulcerative colitis (UC).

Abatacept Efficacy in JIA

Subcutaneous abatacept (Orencia) showed efficacy among children with polyarticular juvenile idiopathic arthritis (JIA) in an open-label phase III trial.

Abatacept Improves GvHD Outcomes

The results from a phase 2 clinical trial presented at the American Society of Hematology meeting demonstrated that the drug abatacept was highly effective in managing severe acute graft-versus-host disease (GvHD) in patients receiving hematopoietic stem cell transplants.

Biosimilar Reports - February 2018

Biosimilars command a great deal of research, development and attention given the promise of significant cost savings and potentially wider use for those in need.  The global biosimilar market is expected to reach $36 billion USD by 2022. Here is this month's roundup of clinical trials and journal articles, overviews/reviews, practice and physician attitudes, and regulatory and pharma news - all on the subject of biosimilars.

Less Cardiovascular Risk with Abatacept in Rheumatoid Arthritis

A claims data analysis shows that abatacept use in rheumatoid arthritis (RA) patients yielded a modestly reduced cardiovascular risk when compared to patients receiving TNF inhibitors (TNFi).