Rituximab Induced Serum Sickness Save

Karmacharya and colleages have reviewed 33 cases of rituximab-induced serum sickness. Half of these patients had the classic triad of SS fever, rash, and arthralgia and a self-limiting course. The time to onset after infusion was greater with the first dose of rituximab compared to the second dose (mean time 10 vs. 4 days). RISS was more common with rheumatologic indications, especially Sjogren's syndrome patients.