Friday, 17 Aug 2018

You are here

Rituximab May Halt ILD in Antisynthetase Syndrome Myositis

A multicenter study assessed patients with the antisynthetase syndrome (AS) and interstitial lung disease (ILD) and found that rituximab (RTX) therapy was associated with either improved or stable pulmonary outcomes in most. 

A retrospective analysis from the University of Pittsburgh and the Brigham and Women’s Hospital pooled their collective experience and analyzed data from 25 patients with AS-ILD, specifically assessing clinical, PFT, and chest CT outcomes using standardized scoring. 

All patients had antisynthetase antibodies (16 withJo-1, 6 PL-12, 3 PL-7). In 21/25 (84%), RTX was prescribed for recurrent or progressive ILD. CT findings included CT nonspecific interstitial pneumonia (NSIP; n = 13) and usual interstitial pneumonia (UIP)/fibrotic NSIP (n = 5), and 5 also had cryptogenic organizing pneumonia.

The 12 month outcomes, comparing pre- and post-RTX pulmonary variables, showed improvement in CT score (88%), FVC (79%), total lung capacity (from 56 ± 13 to 64 ± 13) the the glucocorticoid doses decreased from 18 ± 9 to 12 ± 12 mg/day.

DLCO (%) declined slightly at 1 year, but later increased from 42 ± 17 to 70 ± 20 at 3 years.

These uncontrolled and retrospective data provide preliminary evidence of RTX benefit when treating AS-ILD, a condition that is progressive in most patients.

 

Disclosures: 
The author has no conflicts of interest to disclose related to this subject

Add new comment

More Like This

Success of Stopping Depends on the Biologic

The type of biologic disease-modifying anti-rheumatic drug (DMARD) being used and remission duration were important factors predicting whether remission was maintained among patients with rheumatoid arthritis after cessation of the biologic, a Japanese study found.

IL-1 Suppression May Improve Dilated Cardiomyopathy

 

Interleukin-1 (IL-1) suppression helped reverse symptoms of dilated cardiomyopathy (DCM) for one patient in a case study that may implicate inflammation in the development of the condition.

Defining Refractory RA by Biologic Use

A study from the  British Society for Rheumatology Biologics Register (BSRBR) has shown that biologic refractory disease is seen in at least 6% of patients who have ever received a biologic DMARD (bDMARDs).

IL-23 Inhibitor Fails in Ankylosing Spondylitis

A study of the IL-23 risankizumab in active ankylosing spondylitis (AS) patients failed to show efficacy and did not meet primary efficacy endpoints in a 6-month trial.

Five Barriers to Biosimilar Adoption in the US

A recent Deloitte analysis of the biosimilar market in the USA suggests there are defined obstacles to biosimilar use that must be dealt with, especially as the current administration is seeking to lower drug prices and reduce out-of-pocket costs for US consumers.