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Sjogren's Syndrome at Risk for Psychiatric Disorders

A population-based claims study from Taiwan shows significantly increased incidences of depressive disorder, anxiety disorder, and sleep disorder in patients with primary Sjögren’s syndrome (pSS). 

Taiwan’s National Health Insurance Research Database was the source of this retrospective cohort comparison of 688 patients with newly diagnosed pSS and 3440 patients without pSS and 1302 newly diagnosed patients with rheumatoid arthritis (RA).

pSS patients had a higher risk for depressive disorders (adjusted incidence rate ratio [aIRR] = 2.11, p < 0.001), anxiety disorder (aIRR = 2.20, p < 0.001), and sleep disorder (aIRR = 1.76, p = 0.012) when compared with the non-pSS cohort or the RA comparison cohort.

The peak age group of developing depressive disorder was 65–80 years old (aIRR = 3.46, p < 0.001).  

Primary Sjögren’s syndrome patients (especially women) have a higher risk of developing depression, anxiety and sleep disorders.  The peak age for developing depressive disorders was 65–80 years old.

The author has no conflicts of interest to disclose related to this subject

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