Skip to main content

Skyrizi Outduels Humira in Psoriasis

A head-to-head trial has shown that risankizumab was significantly superior to adalimumab in providing skin clearance (PASI90) in patients with moderate-to-severe plaque psoriasis, with no difference in safety signals between the two agents. 

Risankizumab (Skyrizi), an interleukin-23 (IL-23) inhibitor, was FDA approved for use in psoriasis in April 2019, becoming the the third IL-23 inhibitor (includes guselkumab [Tremfya] and tildrakizumab [Ilumya]) approved in the last year for plaque psoriasis.

The IMMvent trial was a phase 3, randomised, double-blind, active-comparator-controlled trial that enrolled 605 adults with moderate-to-severe chronic plaque psoriasis and randomized them to either risankizumab (RIS) (150 mg subcutaneously at weeks 0 and 4 ) or adalimumab (ADA) (80 mg subcutaneously at randomisation, then 40 mg at weeks 1, 3, 5, and every other week thereafter during the first 16-weeks of the trial (part A). For weeks 16–44 (part B), adalimumab intermediate responders were re-randomised 1:1 to continue 40 mg adalimumab or switch to 150 mg risankizumab.

Co-primary endpoints in part A were a 90% improvement from baseline (PASI 90) and a static Physician's Global Assessment (sPGA) score of 0 or 1 at week 16.

Nearly all of the RIS (98%) and ADA (96%)patients completed part A (first 16 weeks) of the study. 

At week 16, PASI 90 results were:

  • RIS - 72%
  • ADA - 47% (p<0·0001)

In part B, at week 44, the ADA intermediate responders, achieved a PASI 90 in 66% of RIS treated patients and 21% in those continuing ADA therapy (p<0·0001).

Risankizumab showed significantly greater efficacy than adalimumab in providing skin clearance in moderate-to-severe plaque psoriasis.

ADD THE FIRST COMMENT

If you are a health practitioner, you may to comment.

Due to the nature of these comment forums, only health practitioners are allowed to comment at this time.

Disclosures
The author has no conflicts of interest to disclose related to this subject