Wednesday, 17 Oct 2018

You are here

Sons of Gout Study

The genetics and heritability of gout has suggested a higher risk in certain families.  A UK cohort study examined the prevalence of gout and monosodium urate (MSU) crystal deposition among those at risk (sons of gout patients) for gout and found a high incidence of hyperuricemia and MSU crystal deposition.

The sons of patients with gout (n=131) were contacted, screened by telephone and subsequently had a study-visit evaluation for blood and urine collection, and musculoskeletal ultrasonography (MSK US).

Amongst 131 sons of gout, 64.1% had serum urate (SU) ≥6 mg/dl, and 30% had MSK US evidence of either a double contour sign (DCS) or intra-articular aggregates/tophi in ≥1 joint.

All subjects with MSU deposition had involvement of 1st metatarsophalangeal joint and a subset (21%) had intra-tendinous aggregates.

For those with SU ≤5 mg/dl no MSU depositoin was found; but those 24% of those with SU between 5-6 mg/dl had ultrasonographic MSU deposition.

For every SU increased of 1 mg/dl, there was a 61% increase in the odds of finding MSU crystal deposition.

Disclosures: 
The author has no conflicts of interest to disclose related to this subject

Add new comment

More Like This

Allopurinol Shown to be Renal Protective

Neogi and colleagues have shown that standard doses of allopurinol (300 mg/day) were associated with a 13% lower risk of renal function deterioration in chronic gout patients - thus, allopurinol does not appear to impair renal function over time.

Quarterly Canakinumab Reduces Gout Risk Without Affecting Uric Acid

The Annals of Internal Medicine reports that interleukin-1 (IL-1) inhibitor treatment is associated with a reduced risk of gout attacks - such are the findings of an anlysis of the CANTOS study previously reported at the Annual ACR 2017 meeting in Washington, DC. 

Usual Allopurinol Doses Insufficient in CKD Patients

Uric acid (sUA) control may be a challenge in patients with chronic kidney disease (CKD). A cohort study shows that conventional dosing recommendations for allopurinol are unlikely to reach target serum sUA goals.

Sleep Apnea Raises Gout Risk

Patients with obstructive sleep apnea were at increased risk for incident gout, particularly in the first years after the sleep apnea diagnosis, U.K. researchers reported.

In a large retrospective cohort study, the adjusted hazard ratio for a new gout diagnosis among individuals with sleep apnea was 1.42 (95% CI 1.29-1.56), according to Milica Blagojevic-Bucknall, PhD, of Keele University in Keele, England, and colleagues.

Adherence to Gout Therapies Painfully Low

A retrospective study of the large UK Clinical Practice Research Datalink assessed patient compliance in gout and found that adherence to allopurinol is poor, especially among females and younger patients and those with fewer comorbidities.