Thursday, 20 Feb 2020

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Vitamin D Supplements Fail to Prevent Type 2 Diabetes - DUH!

A NEJM report shows that the use of vitamin D3 supplementation (4000 IU per day) in those without diabetes or vitamin D deficiency failed to significantly lower risk of type 2 diabetes (compared to placebo).

The rational for this report included observational data showing an association between a low blood 25-hydroxyvitamin D level and the risk of type 2 diabetes.

They included adults who met at least two of three glycemic criteria for prediabetes (fasting plasma glucose level, 100 to 125 mg per deciliter; plasma glucose level 2 hours after a 75-g oral glucose load, 140 to 199 mg per deciliter; and glycated hemoglobin level, 5.7 to 6.4%). The primary outcome was the time to develop new-onset diabetes, with a target number of diabetes events of 508.

A total of 2423 participants were randomized to either vitamin D or placebo. By month 24, the mean serum 25-hydroxyvitamin D level in the vitamin D group was 54.3 ng per milliliter (up from 27.7 ng/ml at baseline), as compared with 28.8 ng per milliliter in the placebo group (baseline = 28.2 ng/ml).

The primary outcome of developing diabetes occurred

  • Vitamin D group: 293 events (9.39 per 100 person-years)
  • Placeboe group: 323 events (10.66  per 100 person-years)
  • Hazard ratio = 0.88 (95% confidence interval, 0.75 to 1.04; P=0.12)
  • No differences in the incidence of adverse events

(Editors note: I am continually amazed at the number of associations between vitamin D levels and poor health; yet there are little or not studies showing that Vitamin D Supplementation cures, fixes or prevents anything.  Certainly Vitamin D is important for bone health and immune function - but that's about where it ends.  I suggest we continue to take vitamin D supplements (since most of are deficient) daily and stop believing that this supplment is the magic bullet for health)


The author has no conflicts of interest to disclose related to this subject

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