Nice study on referral strategies for #axSpA in pts w/ chronic LBP by Dr @Nellziade 🔸MASTER strategy-optimal reference strategy: IBP, ✅NSAID response, HLA-B27+ & +SpA family hx 🔸Clinical predictive factors: uveitis, IBP, Pso, enthesitis &🚹 #ACR22 @RheumNow ABST#1512 #ACRBest https://t.co/l6AleXX7Kt

Decreased colonic mucus production in HLA-B27 + healthy individuals and axSpA and IBD pts. Abs 1151 #ACR22 @RheumNow https://t.co/CwX4n6PJFy https://t.co/4f1Za0Qhpj

• Colonic Organoids to Study the Role of HLA-B27 in Gastrointestinal Epithelial B…

Biologics to treat gut microbiome dysbiosis?? In axSpA pts treated with bDMARDs for one year, gut microbiome resembled those of controls. Collinsella remained stable - possible biomarker? Abs#1162 @RheumNow #ACR22 #ACRBest https://t.co/vmQFJMpNPP

Abs 1153 at #ACR22 males may have a higher levels of Th17-associated transcription factors. Radiographic progression in men may be mediated by S100 proteins and prostaglandins. @RheumNow https://t.co/mWbsaB8kK8 https://t.co/IkTBZcaqa6

• Differentially Expressed Genes in Males and Females with Ankylosing Spondylitis…

Inflammation causing HTN in AS? Abstract #0384 #ACR22 @RheumNow 🫀413 patients followed for median 12 years 🫀14% developed HTN 🫀Baseline disease duration was an independent RF for HTN 🫀ESR > 20 sig. associated with HTN

Ab1011 #ACR22 @SMerjanah: Fracture rates among vets with AS Increasing fx incidence for AS and comparator groups over time There was increase in fractures during TNFi era 2004-2021 compared to pre-TNFi, does not show fx sparing effect @RheumNow https://t.co/fTSYbFcxqo

Abs 1011 examined fracture incidence rates in AS patients over time in VA cohort - Rate of fractures in AS pts 2.1 per 1000 PY --> 22.8 (1999 --> 2021) vs Comparators 0.4 --> 8.3 - Post TNF era fracture rates increased AS > comparators @RheumNow #ACR22 https://t.co/eUxoTavHGV

What delays diagnosis of AS? #ACR22 @RheumNow Abstract #0328 Diagnosed faster if: 👨‍🦳Older age at back pain onset 🧬HLA-B27+ ✋🦶peripheral arthritis 📍Higher socioeconomic vulnerability had diagnostic delay 👁 uveitis more common in patients with > 4 years dx delay

Analysis from Abs 0954 shows that mainly fatigue and back pain have an impact on the mean BASDAI during pregnancy. #ACR22 @RheumNow https://t.co/l5VGKqF2ar https://t.co/fpkl8VRRJP

• What Drives the BASDAI in Pregnant Patients with Axial Spondyloarthritis? A Poo…

Dr PMease et al looked into impact of TNFi cycling in their #axSpA cohort: 💠After 6mos on 2nd TNFi, only 15% had ASDAS-LDA, 7% MCID in ASDAS, 8% >50% improvement 💠Cycling to 2nd TNFi limited benefits ⬇️sample size, worth further investigation #ACR22 @RheumNow ABST#1499 https://t.co/OVJxezdipW