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Articles By Jack Cush, MD

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Many with Psoriatic Arthritis Fail to Achieve Minimal Disease Activity

29 February 2024

Despite the availability of numerous advanced therapies for psoriatic arthritis (PsA), there remains a substantial burden and unmet need for improved therapies, according to a newly published Canadian study.

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Polyarteritis Nodosa: Clinical Features and Outcomes

29 February 2024

A multinational study of polyarteritis nodosa (PAN) through the international GLOBAL-PAN network shows PAN to be a complex, multisystem disorder with a high risk of relapse and low risk of death (11% at 10 years).

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Excess Cardiovascular Risk in Gout

28 February 2024

A UK population cohort study has shown that gout carries an increased risk for a wide variety of cardiovascular disorders.

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Can Biomarkers Improve Cardiovascular Risk Assessments in RA?

28 February 2024

The TARGET (Treatments Against RA and Effect on FDG PET/CT) trial showed that different treatment strategies equally benefited arterial inflammation (by FDG-PET) in rheumatoid arthritis. A subsequent analysis of these patients showed several candidate biomarkers that may correlate with baseline and treatment‐associated changes in arterial inflammation in patients with RA. 

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EGPA: Benralizumab or Mepolizumab

26 February 2024

A multicenter, double-blind, phase 3, randomized, active-controlled trial has shown that Benralizumab (BEN) was noninferior to mepolizumab (MEP) for the induction of remission of patients with relapsing or refractory Eosinophilic granulomatosis with polyangiitis (EGPA).

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Behçet’s Syndrome

26 February 2024

A comprehensive overview of Behcet's syndrome appeared in last week's NEJM, reviewing the numerous advances in the immunogenetics, syndrome recognition, and targeted therapeutic approaches.

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Immunosuppression Increasing (2.23.2024)

23 February 2024

Dr. Jack Cush reviews the news and journal reports from the past 2 weeks on RheumNow.com; but begins with a discussion of what constitutes "immunosuppression" and how it applies to our patients.

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CD19 CAR T-Cell Therapy in Autoimmune Disease

22 February 2024

The NEJM has published the results of CD19 B cell depletion (by CAR-T cell therapy) in autoimmune disease patients, demonstrating it to be feasible, safe, and efficacious.

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ARIAA Trial: Abatacept Delays the Onset of RA

20 February 2024

The ARIAA trial tested the utility of IV abatacept in individuals ACPA+ arthralgia patients with subclinical inflammation and showed abatacept to decrease MRI inflammation, clinical symptoms, and risk of future rheumatoid arthritis (RA) development.

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Cochrane Review: How Good is Ultrasound Diagnosing GCA?

19 February 2024

Is temporal artery ultrasound equivalent or superior to the reference standard of temporal artery biopsy when diagnosing giant cell arteritis (GCA)?

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