sheila RHEUMarampa
1 week 1 day ago
What’s new with the 2026 update of reco for vax in AIIRD?
Vaccinate as soon as possible
Non-live vaccines are safe
Hold MTX for upto 2wks to inc vax yield
Strong reco for RZV
Catch-up vax for HPV in SLE
Rotavirus vax for newborns exposed in utero to TNFi
@RheumNow #EULAR2026 https://t.co/RZbyvAcYRI
Janet Pope Janetbirdope
1 week 1 day ago
Good performance of #definite
#antisynthetase #syndrome
✅+antibody mandatory
Possible also does ok
@RheumNow #EULAR2026
June 6 #antisynthetase #classifiaction #criteria https://t.co/5sxogTX9YT
sheila RHEUMarampa
1 week 1 day ago
Dr. Cavagna presents the 2025 EULAR/ACR Classification Criteria for Anti-Synthetase Syndrome
He emphasizes the inportance of ruling out anti-MDA5 Ab & anti-PM/Scl Ab DM since these conditions share overlapping features w/ ASyS.
@RheumNow #EULAR2026 https://t.co/AtGRlp5qyW
sheila RHEUMarampa
1 week 1 day ago
Do u screen your SLE pts for OP?
In this real-world multicenter study, SLE pts who were likely to be tested for BMD were older, had MSK s/sxs, sSJg & longer GC exposure.
RFs for OP: LN, higher dse. activity, longer GC use, high cumulative GC dose
POS1372 @RheumNow #EULAR2026 https://t.co/pAxhOPGGYs
At EULAR 2026, investigators are presenting perhaps the most biologically compelling data yet from the REGENCY trial, with evidence that obinutuzumab induces deep intrarenal B-cell depletion alongside markedly higher rates of histological remission.
Md Yuzaiful Md Yusof Yuz6Yusof
1 week 1 day ago
#EULAR2026 POS1139 Pay attention in #SLE with anti-Sm+ RNP+. Data from 3 RCTs & a cohort:
-enriched in Black patients
-poor response to B-cell depletion inc. Obi
-non-response is assoc. with BAFF-dependent B-cell repopulation. So, use Belimumab
-High ferritin = flare @RheumNow https://t.co/3uDMigY8i2
Antoni Chan MD (Prof) synovialjoints
1 week 1 day ago
Abstr LB0003
Off-the-shelf allogeneic NK cell therapy + rituximab in refractory RA, Sjögren disease, and systemic sclerosis. 31 patients. Outpatient administered.
RA at 6 months: 71% ACR50, mean CDAI change −36.8. SSc: 100% rCRISS25 response. SjD: 86% ClinESSDAI responders. https://t.co/60046jgYia
sheila RHEUMarampa
1 week 1 day ago
Interesting data on the effect of AB-101 + RTX on refractory RA, SSc and SjD.
Curious about long term results and potential position in tx strategies
LB0006 @RheumNow #EULAR2026 https://t.co/opbh8yGmwO
Janet Pope Janetbirdope
1 week 1 day ago
#SLE Rx options
Determining #MOA
#TYK2 #sig w #deucravacitinib
#IFN sig in active #SLE
⬇️ in
#anifrolumab
#upa
#deucra
#repeat renal #bx in #obinutuzimab ➡️
Clears B cells
#Dapriluzimab & other MOAs
⬇️AntiDNA
⬆️complements
#EULARbest @RheumNow #EULAR2026 #POS1364, OP0160,336
Md Yuzaiful Md Yusof Yuz6Yusof
1 week 1 day ago
#EULAR2026 LB0003 CAR-T is not scalable. In a Phase 2a of off-the-shelf AB-101 allogenic NK + low dose conditioning (Cyclo & Flud) + Rituximab: preliminary efficacy & safety profile in severe-refractory RA (N=15), SjD (11), SSc (5). Longer FU & Comparator is needed @RheumNow https://t.co/gQniufREQC
Md Yuzaiful Md Yusof Yuz6Yusof
1 week 1 day ago
#EULAR2026 LB0004 First BiTE, now TriTE! Tri-specific CC312 CD19/CD3/CD28 (i.e. CD28 co-stimulates Tcell activation) showed deep Bcell depletion, early efficacy & safety in 10 #SLE patients up to 52WKs. Promising but longer FU needed to see if repeat dosing needed @RheumNow https://t.co/6Lbm9LYJrY
sheila RHEUMarampa
1 week 1 day ago
JASMINE-SLE: Proof of concept study on
Nipocalimab for SLE
SRI-4 met at wk 24 for the 15 mg/kg q2w dose va. PBO
Improvement of SRI-4 composite & LLDAS at wk 52
LB0007 @RheumNow #EULAR2026 https://t.co/0wzHyid3dy
Md Yuzaiful Md Yusof Yuz6Yusof
1 week 2 days ago
#EULAR2026 LB0006 Beyond conventional immunosuppressant, a multicentre RCT (N=145) in China showed mTOR-i Sirolimus + SOC met primary endpoint (SRI-4) vs PBO + SOC in #SLE. Favourable safety. Frequent AE: high cholesterol & low WCC. Unclear position in treatment pathway @RheumNow https://t.co/OiFp06467v
Janet Pope Janetbirdope
1 week 2 days ago
5 top abstracts in #Myositis @eular_org
1 #Nailfold #capillaries as an early marker of #IIM Rx
2 #brepocitinib +RCT #DM
3 & rapid skin improvement #CLASI
4 #Ab may help #IBM but neg primary endpoint
5 #criteria for #antisynthetase
#EULAR2026 @RheumNow
OP0168, 0166, 0164 POS264