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      CAR-T For Rheumatoid Arthritis
      The first day of EULAR 2026 in London featured the opening ceremonies, a plenary session, posters nd the first round of major oral presentations to an audience of nearly 15,000 attendees. Here are a few of my favorites from the first day.
      Clinicians often come across the scenario of a patient with well-controlled spondyloarthritis where the ASDAS in the low disease activity range, CRP normalised, joints clinically quiet. However, the patient returns to the clinic still reporting significant pain. Their rheumatologist adjusts the biological, waits, returns. The pain persists.
      Over 70% of patients with PsA struggle with excess weight, amplifying synovio-entheseal inflammation and blunting biologic response. The rapid uptake of GLP-1RAs in rheumatology has raised an urgent mechanistic question: are clinical gains in PsA driven purely by weight reduction, or do these agents carry intrinsic anti-inflammatory properties? EULAR 2026 offered six abstracts that together illuminate, without fully resolving, this question.
      📈 Do SIJ lesions progress in #axSpA?

      DESIR cohort (n=649, 10yrs):
      Yes, slowly, but bDMARDs reduce erosion progressi

      Nelly ZIADE 🍀 Nellziade

      1 week 2 days ago
      📈 Do SIJ lesions progress in #axSpA? DESIR cohort (n=649, 10yrs): Yes, slowly, but bDMARDs reduce erosion progression #OP0102 #EULAR2026 @RheumNow https://t.co/Ap35q9D6B4
      🔍 Best imaging outcome for #axSpA structural change?

      SPACE cohort (n=332): MRI-SIJ fat lesions most sensitive to cha

      Nelly ZIADE 🍀 Nellziade

      1 week 2 days ago
      🔍 Best imaging outcome for #axSpA structural change? SPACE cohort (n=332): MRI-SIJ fat lesions most sensitive to change #OP0103 #EULAR2026 @RheumNow https://t.co/His1BGYmEW
      🖥️ Can MRI-based synthetic CT detect spinal progression in #axSpA?

      COPECARE (n=25, 1yr): sCT matches ldCT with no

      Nelly ZIADE 🍀 Nellziade

      1 week 2 days ago
      🖥️ Can MRI-based synthetic CT detect spinal progression in #axSpA? COPECARE (n=25, 1yr): sCT matches ldCT with no radiation #OP0104 #EULAR2026 @RheumNow https://t.co/pe9wSMXXZQ
      🔍 Is #axSpA overdiagnosed locally?

      IMPROVE-axSpA prosp study (n=969):
      Yes!

      Only 54% locally confirmed centrally

      #

      Nelly ZIADE 🍀 Nellziade

      1 week 2 days ago
      🔍 Is #axSpA overdiagnosed locally? IMPROVE-axSpA prosp study (n=969): Yes! Only 54% locally confirmed centrally #OP0105 #EULAR2026 @RheumNow https://t.co/VqCPbbCHLB
      🔍Can early TNFi beat step-up csDMARDs in pSpA?

      SPARTACUS RCT (n=97) says YES
      60% vs 33% remission at 24 wks

      #EULAR2

      Nelly ZIADE 🍀 Nellziade

      1 week 2 days ago
      🔍Can early TNFi beat step-up csDMARDs in pSpA? SPARTACUS RCT (n=97) says YES 60% vs 33% remission at 24 wks #EULAR2026 @rheumnow #OP0107 https://t.co/1odtcRdTLQ
      💉 IXE+TZP beat IXE alone in obese PsA?

      YES - TOGETHER-PsA RCT
      33.5% vs 20.4% ACR50 at week 36 in 271 patients

      OP069

      Nelly ZIADE 🍀 Nellziade

      1 week 2 days ago
      💉 IXE+TZP beat IXE alone in obese PsA? YES - TOGETHER-PsA RCT 33.5% vs 20.4% ACR50 at week 36 in 271 patients OP069 #EULAR2026 @RheumNow @DrLauraCoates @AlexisOgdie https://t.co/orvAe38alc
      🥗 Does diet improve PsA?

      DIPSA RCT: Mediterranean/DASH/Standard all improved DAPSA in 92pts

      Weight loss drove outco

      Nelly ZIADE 🍀 Nellziade

      1 week 2 days ago
      🥗 Does diet improve PsA? DIPSA RCT: Mediterranean/DASH/Standard all improved DAPSA in 92pts Weight loss drove outcomes OP070 #EULAR2026 @RheumNow https://t.co/k5y7bvDbDQ
      Results of this 10yr ffup study on impact of sex on clinical outcomes & spinal xray prog in SpA:
      Females ⬆️ dse

      sheila RHEUMarampa

      1 week 2 days ago
      Results of this 10yr ffup study on impact of sex on clinical outcomes & spinal xray prog in SpA: Females ⬆️ dse act (asdas,basdai) ⬆️enthesitis scores, S/TJCts Males ⬆️rate of xray prog(msasss) Sex diffs exist in SpA Need for sex-specific mgt AbsOP0101 @Rheumnow #EULAR2026 https://t.co/qiNzDFh08v
      #EULAR2026 OP028 In 16 patients with AID (SSc,IIM, RA, IgG4,SjD, Grave’s), CD3xBCMA BiTE, Teclistamab was effective in

      Md Yuzaiful Md Yusof Yuz6Yusof

      1 week 2 days ago
      #EULAR2026 OP028 In 16 patients with AID (SSc,IIM, RA, IgG4,SjD, Grave’s), CD3xBCMA BiTE, Teclistamab was effective in 15/16. Duration of GC & DMARD-free was 11 mths. 2/16 need retreatment. All had low IgG and needed IVIG. Need long-term safety data & comparative study @RheumNow https://t.co/97MUPnXRua
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