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RheumNow Podcast – Upadacitinib FDA Approved for RA (8.23.19)

Dr. Jack Cush reports on the news and journal reports from the past week on

  1. RCT of 139 knee OA pts given either curcumin 500-mg tid or diclofenac 50-mg bid. At days 14 and 28 both had similar improvement in pain and KOOS score; but curcumin had better tolerance, less GI sxs and H2 blocker use.
  2. CMAJ reports on a case controlled study of >3000 pts shows GERD to be a a risk factor for TMJ disorders (OR 2.74; 1.88 to 3.98) with such patients having a higher rates of somatization, anxiety and sleep disorders. 
  3. Analysis of 128 Pediatric Rheum pts (JIA, FMF, etc) analzyed for reactions to 8 different biologics during 32,494 infusions/injections - the frequency of anaphylaxis (from TCZ or RTX) was 3.9% in children. 
  4. Dermatomyositis with anti-MDA5 Ab is at high risk of severe rapid interstitial lung disease. Study of 31 MDA-5+ pts shows those with pneumomediastinum at higher risk for mortality, liver dysfunction, worse respiratory dz and Chest CT scores 
  5. 87 #Gout patients treated with ULT and followed with serial Xrays and DECT scanning shows that lowering uric acid in a T2T strategy did not change xray over 2 years, but did show significantly less urate erosions by DECT. 
  6. Studies analyzing the microbiome (by 16S ribosomal RNA bacterial gene testing) of 107 healthy subjects, and 696 twin pairs from the TwinsUK cohort shows that the microbiome is significantly and uniquely influenced by HLA- B27 and HLA–DRB1.   
  7. Upadacitinib (RINVOQ) FDA Approved for Rheumatoid Arthritis  
  8. Skyrizi Outduels Humira in Psoriasis     
  9. Good Pregnancy Outcomes for DMARD Exposed JIA Patients   
  10. Part 4 - War on RA - Desperado, the Eagles, Glenn Fry inspire Desperado to stop riding fences - on RheumNow; heres the video>> or listen to the podcast on iTunes or here>>
  11. – a new website on AOSD, PF, AID, Diagnosis calculator


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