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The RheumNow Week in Review – 10 March 2017

Dr. Jack Cush reviews news and highlights from the past week on RheumNow.com.  Sign up at RheumNow.com to received daily or weekly news, blogs and tweets on all things rheumatology

  1. 2015 study of 4504 IBD pts shows TNFi use has 2 fold risk of central demyelinating Dz, w/ absolute risk 3.9/10000 PY http://buff.ly/2mdr9QK
  2. ~28000 Acute Coronary syndr finds increasing Uric Acid Leves is assoc w/ increased risk of CV events, regardless of gout https://t.co/5tKEcQ2o4g
  3. IgG4 related Skin Dz:red/itchy plaques, subcut nodules/papules, Pso-like lesions,Palp purpura, urticarial vasculitis https://t.co/tsD1m3cvpK
  4. Analysis of FDA FAERS database shows TNF inhibitor ISRs are lower in pts >70yrs & lower when TNFi combined w/ MTX https://t.co/B4t6ivsQDG
  5. ANCA-assoc vasculitis pts who are chronic carriers of nasal Staph aureus have more relapses vs noncarriers(15% v 2%) https://t.co/dTACPMfsXA
  6. AAD reports that Taltz was superior to Stelara in plaque Pso w/ PASI-100 scores of 49.3% vs 23.5% (P<0.001) @WK16 24 https://t.co/uGDpnwkX93
  7. 461 pts w/ plaque psoriasis in CIMPASI1&2 studies whowed PASI75 of 76-83% @400q2wk, 66-81% @200mg. 6.5-11% PBO @wk16 https://t.co/obabnhq6Sb
  8. Unmonitored Biologic DMARD discontinuation (w/o restarts) yields high flare rates, worse function, more Xray damage https://t.co/FEvuXtuSuW
  9. Placebo outperforms Anakinra (22% vs 8%) in 50 patients with chronic Fatigue Syndrome. IL-1 inhibition fails in CFS https://t.co/c1PW8aglhU
  10. Women infected the Zika virus have a >20 fold greater risk of babies with (compared to before Zika epidemic). https://t.co/Iv1rZzvJHU
  11. Claims data of 8357 non-OP Women w/ Hip Fx shows only 17% had DXA after Fx & only 23% were screened/Rx for OP @1yr https://t.co/vdPvz5fRY
  12. CDC Says 1 in 5 Have Arthritis (54.4 million adults) 
  13. Methotrexate and Folate Use by Rheumatologists - Survey Results published.
  14. TNF Inhibitor Therapy and the Risk of Anterior Uveitis Recurrence in >1400 AS pts; 2-4x higher w/ ETN
  15. Meta-analysis Reveals Numerous Pregnancy Complications Associated with Lupus 
Disclosures: 
The author has received research/grant financial support on this subject
The author has received compensation as an advisor or consultant on this subject

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