Wednesday, 14 Nov 2018

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RheumNow Week in Review – Father Knows Best (Paternal Drugs OK) (8.31.18)

Dr. Jack Cush reviews the news and journal articles from the past week on  Cool info on paternal exposures to DMARDs/Biologics, Contraceptive let downs, good outcomes in PsA, depression-insomnia-pain triad in OA and how to store your biologic in a hurricane.

  1. Study of 2,976 osteoarthritis patients shows primary drivers to healthcare utilization are moderate to severe pain (47%), insomnia (55%) and depression (45%)
  2. The BSRBR has published outcomes on their PsA cohort. Incidence of overall malignancy similar to general population, although non-melanoma skin cancer increased. All-cause mortality increased (SMR 1.56), driven by coronary heart disease.
  3. Low use of Contraception Among 2455 Rheumatic women; 32% used contraception, 8% used highly effective methods (IUD, implants, sterilization). Fetotoxic med use (> 70% of pts) was not assoc w/ Rx contraceptivs but was assoc w/ high effective contraception.
  4. FDA info on insulin use during disaster/hurricaine applies well to biologic use - "...that insulin be stored...~36°F to 46°F" until use... but "may be left unrefrigerated at 59°F to 86°F for up to 28 days and continue to work" Avoid extremes in temp!
  5. Treatment Preferences in Still’s Disease  
  6. Adherence to Gout Therapies Painfully Low  
  7. The Safety of Paternal Exposure to DMARDs and Biologics   
  8. Not All Hyperuricemia Leads to Gout   


The author has received compensation as an advisor or consultant on this subject

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