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By Jack Cush, MD | 15 April 2016
Video recap of highlights from this week at RheumNow.com.
- In patients with connective tissue disease and interstitial lung disease (ILD): NSIP, UIP, OP (use to be BOOP), LIP are NOT diagnoses - these are lung injury patterns with clinical associations and correlations. (Courtesy of Dr. Aryeh Fischer at the ARTHROS W. Virgina State Rheumatology Meeting)
- UIP (Usual interstitial pneumonia) is best diagnosed by HRCT; appears as honeycombing; and is the most common form of ILD. It is also the most common cause of ILD in rheumatoid arthritis and second most common in PSS and other CTD.
- NSIP (nonspecific interstitial pneumonitis): shows as ground glass opacities; most common ILD pattern in PSS and other CTD. NSIP has better survival than UIP.
- Who should get HRCT after CXR and PFTs? Each of the following increase the likelihood of having significant ILD: consider in Men, smokers, CCP+, RA patients. CCP+ is independent risk factor for ILD.
- The majority of PSS patients will have ILD (fibrotic NSIP is most common). ILD is the leading cause of death in PSS.
- In 658 hospitalized PSS patients, there were 29 deaths. The risk factors associated with death was ascertained; - higher risk with high BUN, history of aspiration, low Hgb, non-SSc lung disease.
- In an IBD cohort study, perioperative MTX use was not associated with an increase in post-operative complications or sepsis in IBD pts having abdominal surgery.
- Colchicine once daily is equivalent to twice daily dosing in preventing attacks with Familial Meditteranean Fever
- A metanalysis of 4 RCT using rituximab (RTX) in Sjogren’s syndrome: 276 patients saw that RTX had no effect on Schirmers test, fatigue, ESSDAI & SF36 after 24 weeks.
- Surgical Management of Spinal Stenosis - To Fuse or Not To Fuse?
- Lupus Patients Genomically Stratified to Explain Treatment Responses
- Population-Based TB Risk and Prevention with RA and Biologics
- A Rocky Start for Biosimilar Inflectra?