Lupus

TheDaoIndex KDAO2011
3 years 10 months ago
Dr. Furie asked Dr. Touma what he was doing in 1976? Dr. Touma said, "I was not even in school, yet." Dr. Furie noted that in 1976, the first study was published on methylprednisolone pulse for lupus nephritis in 7 patients. #ACR21 @rheumnow Link below https://t.co/Oe9xmH7Tzg https://t.co/xslAHYNXej


Dr. Laura Lewandowski LauraLewMad11
3 years 10 months ago
#ACR21
#SLE #COVID19
Use of Telemedicine for follow-up of SLE in COVID19
Wait times lower for telemedicine
Patient satisfaction higher in telemedicine group
More hospitalization, higher switch to in person follow up in telemedicine https://t.co/Y21Vki1uDP


Dr. Laura Lewandowski LauraLewMad11
3 years 10 months ago
#ACR21
#SLE
SLE – Treatment: New Agents, Old Agents
Pooled data from 2 phase 3 trials (TULIP 1 and 2)
⏬LLDAS is an attainable T2T endpoint in adult SLE trials
⏬Anifrolumab treatment associated with earlier and more sustained LLDAS in adult SLE https://t.co/bxGlVsJOZC


TheDaoIndex KDAO2011
3 years 10 months ago
👉HCQ dose < 400 mg/d are assc with SLE flare. Lower doses of HCQ may decrease risk of retinopathy. 👉For >80 kg (176 lbs), any dose < 400 mg/day is assc with increased odds of flare
(HCQ blood levels not measured)
Abst#1462 #ACR21 @rheumnow https://t.co/5tx3kruT8W


Richard Conway RichardPAConway
3 years 10 months ago
Trauma associates with subsequent increased flares of SLE. Abstr#1446 #ACR21 @RheumNow https://t.co/QeNXOjHAjn

Differentiation between a flare of disease and infection in patients with autoinflammatory (AI) conditions, where fever is the hallmark, can be extremely difficult. Few studies have evaluated potential differentiators; and having such tools would meet a huge unmet need.

Janet Pope Janetbirdope
3 years 10 months ago
#volcosporin good ~lupus nephritis added to #MMF but underbelly - side effects like but ?less than #cyclosporin. #FDA update - ⬆️hypertension and nephrotoxicity, infection #ACR21 @RheumNow https://t.co/w5nLLSTlrB

Pedro Castillo _Castillo_Pedro
3 years 10 months ago
BAFF & APRIL support B cell development, diff, survival.
ALPN-303: Antagonist of both BAFF & APRIL
💠⬇️B cell fxn & Ab production,⬇️Plasma cells
💠⬇️UProt, dsDNA, renal immune complexes (mouse model)
💠Pending human studies
https://t.co/kzVpUDuNWs
#ACR21 Abst#1429 @RheumNow

Janet Pope Janetbirdope
3 years 10 months ago
Are you using less #rituximab in #SLE during #COVID #ACR21 @RheumNow #Lupus hub

TheDaoIndex KDAO2011
3 years 10 months ago
"Baseline and routine EKGS are NOT required for SLE patients just because they are on HCQ!" - Dr. HM Belmont. "The drug has been demonized due to its use in COVID patients. We don't need to hold HCQ for EMR alerts (e.g, with cipro, SSRIs, etc)." Abstr#1743 #ACR21 @rheumnow https://t.co/5Bxavo6dRg


Janet Pope Janetbirdope
3 years 10 months ago
#PJP prophylaxis debate at #lupus hub if on #prednisone + immune suppression. #SLE has ⤴️septra side effects. Don’t know right answer. NNT v NNH is unknown. I don’t use it in #SLE. @RheumNow #ACR21 8M212

Janet Pope Janetbirdope
3 years 10 months ago
#SLE study hub re #Lupus nephritis rocks. #Rituximab ⬇️antiDNA but then rebound ⤴️. Thus design of adding #belimumab to Rituximab=Less flares. Love the Hubs. #ACR21 @RheumNow https://t.co/MAhxJdmkWO 10.7326/M21-2078 #ACRBest https://t.co/qWPk5x1ZtM
