Phase 2 German study demonstrates superiority of TCZ vs PBO in FMF. SAA levels only normalized in TCZ treated patients. Interesting concept that needs to be replicated in larger trials. Abs 0193 #ACR21 #RheumNow @RheumNow https://t.co/awqOpwg3gH https://t.co/lGzYglnkyM

• Tocilizumab for the Treatment of Familial Mediterranean Fever – a Randomized, D…

Abst0242 #ACR21 @RheumNow FROST: 1st line Rx of SJIA 73 pts. two study arms: biologics & GC/MTX arm. In biologic arm 14% IL-1i switched to IL-6i, 0% from IL-6i to IL-1i. 50%GC/MTX eventually initiated biologic therapy . 57% of pts d/cGC use, and 75% had cJADAS-10 score ≤ 2.5 https://t.co/vH0AnocTr2

Still like one of those people like me who struggles with the acronym #VEXAS? Here we go! 1⃣Vacuoles, 2⃣E1 enzyme, 3⃣X-linked, 4⃣autoinflammatory, 5⃣somatic Year in review at #ACR21 @RheumNow https://t.co/gMgFPF6NcS

• https://www.nejm.org/doi/full/10.1056/NEJMoa2026834