Can we stop RA developing? Not previously. Double-blind RCT: - arthralgias+ACPA+MRI changes - but no clinical synovitis - abatacept for 6m didn't progress to arthritis: 92% v 65% improvement in MRI: 61% v 31% + benefit to 18m not shown "provocative"! #ACR21 ABST0455 @RheumNow https://t.co/TGxCBhk4r9

#ACR21 Abst#0155 ⭐︎ Tenosynovitis on MRI hand/foot in ACPA(-) undifferentiated oligo-arthritis pts is predictive of RA ➡️NPV 93%, Se 85% ⭐︎ BM edema not prognostic of RA development Do you already use MRI to help detect early RA? @Rheumnow https://t.co/mpageAYeT2

• The Additional Value of MRI in Diagnosis of Rheumatoid Arthritis in Undifferent…

ARRIA Study: Abatacept vs PBO in pre-clincial RA (N98) pts x 6 mos. Showed ABA prevented arthritis (8 vs 35%), improved MRI inflamm (61 v 31%), fewer D/C (14 vs 43%) - all signif. Further FUV 12 mos off therapy still significant at 18mos #ACR21 Abstract 0455 https://t.co/ZxFUj6KfLT

#ClinicalPearl What lasts longer/⬆️retention in sero+ RA: Abatacept or TNFi or JAKi? #ACR21 abst#0463 @RheumNow Adjusting for confounding incl line of Rx / past bio Rx, #abatacept wins. But data not stratified for bio naive or exposed. Not sure if that would alter results https://t.co/1dEQncwPQF

What increases risk of RA-assoc #bronchiectasis, separate from #RA-ILD? Results from @BrighamResearch find seropositivity (esp high +ve RF/CCP), older age, disease duration, & low BMI incr. risk of isolated bronchiectasis in RA. #ACR21 Abs#0288 @RheumNow https://t.co/jvvRucqTjL https://t.co/aFCfxrbUdV

• Demographic, Lifestyle, and Clinical Risk Factors for Rheumatoid Arthritis-Asso…

@BethIWallace et al. on fibromyalgianess and GC in #rheumatoidarthritis pts. Accdg to their study, pts w/⬆ levels of fibromyalgianess at BL had higher odds of GC persistence on ffup. Something to consider when evaluating need for GC adjustment. @RheumNow #ACR21 abs0120 https://t.co/MTWEXGHJ2n

#ACR21 Abst#0290: Ever wonder about other predictors of mortality in pts w/ RA-Lung Disease besides ILD (OR 2.3) or older age? ⭐︎ ↑ mortality associated w/ pleural effusions (OR 3.3) AND, notably... ⭐︎MTX use was protective (OR 0.4)!!! @RheumNow https://t.co/KKRkQVY2pf https://t.co/JsU2Rqzi6R

• Developing a Score to Predict Preclinical Interstitial Lung Disease in Patients…

This study looked into the prevalence of subclinical atherosclerosis in #rheumatoidarthritis pts w/n 5 yrs of dx using carotid US. 📌vs. controls, RA pts had ⬆ CPs, cIMT ❗Screen RA pts for CV risk early on in their diagnosis @RheumNow #ACR21 abs0271 https://t.co/btU6IcM3xb

#ACR21 Abst#0293 RA patients with lung disease have increased rates of SSc-specific autoantibodies compared to RA w/o lung disease. ▶️ Suggests we may need to investigate further into overlap phenotype in RA-ILD @Rheumnow https://t.co/04FFuBUKmA https://t.co/A83kaie2gr

• https://bit.ly/3mPlqkW

#Flu vaccine coverage remains low in patients with #rheumatoidarthritis. Results from @earlyarthritis Abs#0141 https://t.co/DoZl5xyq2Q How can we increase vaccine uptake in our patients? @RheumNow https://t.co/nldA63EcVW

• Who Gets Influenza Vaccinations Prior to and After a Diagnosis of RA? Results f…

Dr O'Brien on co-existent AAV and RA. Not something I'm used to seeing, but maybe we need to think about it more? 25 cases with RA+AAV, 52 with RA + ANCA but no AAV, not sure what the denominator is here though. Abstr#0428 #ACR21 @RheumNow @profgayecunnane https://t.co/fN3BRpc7UJ

🔥 Ready for the next level of imaging? The radio-labelled tracer binding to integrin αvβ3 99mTc-maraciclatide is able to detect hypervascularization in RA joints and correlates w/ PDUS findings ⭐️ Sens 78% ⭐️ See 91% Fancy, yet more invasive than US! #Abst0174 @RheumNow #ACR21 https://t.co/eCOxjJsERh

Dr Adachi presents ⬆️BMD gain with denosumab than risedronate in RA. Non-significant reduction in fractures (very small numbers) Interesting, but need to see fracture benefit in larger study to justify dmab as first line Abstr#0445 #ACR21 @RheumNow https://t.co/GgaS9JZGzb

What's the added value of MRI in diagnosing #rheumatoidarthritis among pts w/ undiff'd arthritis? Accdg to this study by N. Hollander et al, Tenosynovitis was independently assoc'd w/ RA development esp. among ACPA- UA pts 👇 @RheumNow #ACR21 abs0155 https://t.co/F6xlZ1Hy7u

Don't forget to discuss Influenza vaccination w/ your RA patients! Higher concerns about RA medications and low necessity of vaccination beliefs associated with a ⬇️ likelihood of vaccination and suboptimal vaccine coverage. #ACR21 @RheumNow #Abst0141 https://t.co/c5GthZxh3n https://t.co/4Nt92CHFzV

• Who Gets Influenza Vaccinations Prior to and After a Diagnosis of RA? Results f…