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Mrinalini Dey DrMiniDey
3 years 1 month ago
Safety update for #filgotinib in #RA over ~2.2yrs treatment
👉🏼Well-tolerated with no ne safety concerns since 2020
👉🏼AE incidence rates decreased or remained stable
👉🏼Slight incr rates of NMSC & non-NMSC malignancies
Abs#1698 #ACR21 @RheumNow
https://t.co/0jbZFVgiyN https://t.co/yOlntLwQlU
Eric Dein ericdeinmd
3 years 1 month ago
#ACR21 Ab#1655. Respiratory Ifn in RA on bDMARD
▶️1 group was initiated into vaccination program vs usual care
⭐️Vaccinated group had ⬇️ admissions from respiratory ifns. 44% ⬇️ severe resp ifn
💉programs work!
@Rheumnow https://t.co/pljR6DbAtU https://t.co/goSHGID8qG
Dr. Antoni Chan synovialjoints
3 years 1 month ago
Isolated axial involvement exists in 2-5% of PsA patients. In 576 patients 495 (31.4%) had axial disease, of which 32 (2.0%) had isolated axial disease. HLA-B*27+ and lower HAQ scores were associated with isolated axial disease @RheumNow #ACR21 Abst#1775 https://t.co/Y1EAJlA0mT https://t.co/8oZhN3mT30
sheila RHEUMarampa
3 years 1 month ago
In this study:
💊No correlation bet QTc interval & whole blood HCQ level regardless of dose, CKD or abnormal TTEs in #lupus pts
💊+correlation bet QTci & HCQ levels in pts w/ QTc prolonging drugs but not >456ms
Reassuring, dispels concern on HCQ use
@RheumNow #ACR21 abs1743 https://t.co/kpASRAXJB1
Mrinalini Dey DrMiniDey
3 years 1 month ago
#Multimorbidity in women with #rheumatoidarthritis is increased compared to men with RA. However, women and men without RA have similar levels of multimorbidity.
Abs#1656 #ACR21 @RheumNow
https://t.co/iXhXOldTy0 https://t.co/CsOM7odE69
Eric Dein ericdeinmd
3 years 1 month ago
#ACR21 Ab#1658 - Autoimmune Risks in Relatives of RA pts. 1st degree relatives have risk of:
▶️ AI thyroid (OR 1.3)
▶️ Celiac (1.5)
▶️ SLE (1.3)
▶️ IBD - no ⬆️ risk
⭐️1st, 2nd, 3rd degree relativ: ⬆️ risk of RA
⭐️2nd degree: ⬆️ risk SLE
https://t.co/ATHdemoF45 @Rheumnow #ACRbest https://t.co/JcuZmg9L8E
Aurelie Najm AurelieRheumo
3 years 1 month ago
GLORIA RCT: 400+ pts. Low dose Pred in RA >65yo on top of other treatments 2yrs.
Authors conclude benefit/risk balance in favour of GCs 🧐
2 thoughts:
1️⃣ CV risk linked to GCs ⬆️ over time and cumulative dose: Follow up= short!
2️⃣ Small # for CV events
#ACR21 #Abst 1678 @RheumNow https://t.co/QECJR68ZJu
Richard Conway RichardPAConway
3 years 1 month ago
Dr Deike on prevalence and incidence of PsA in Germany. Prevalence 5-6/1000. Incidence 30-40/100000. Marked age variations that don't really make sense for prevalence. Abstr#1785 #ACR21 @RheumNow https://t.co/uW0ruW2Jda
Mrinalini Dey DrMiniDey
3 years 1 month ago
What is the likelihood of developing an #autoimmunedisease in first-degree relatives of pts with #RA?
Genealogical & phenotypic data suggests lower threshold for screening for autoimmune thyroiditis, #coeliac & #SLE in FDRs.
Abs#1658 #ACR21 @RheumNow
https://t.co/PdSZ05elsf https://t.co/AkIXDkWCM8
Eric Dein ericdeinmd
3 years 1 month ago
#ACR21 Ab#L02 - #COVID19 vax in rheumatic pts:
❌No ⬆️ in disease activity scores post-vaccination
❌No serious adverse event
▶️Vax response 88% in RA, 78% in SLE, 87% other rheum diseases after 2 shots vs 100% controls
⭐️RTX and MMF ⬇️ responses
@Rheumnow https://t.co/BChhmW0jpy https://t.co/2q8IKRoYqW
Richard Conway RichardPAConway
3 years 1 month ago
Dr Hebing on s/c vs oral methotrexate. erythrocyte methotrexate polyglutamates significantly higher with s/c administration. s/c consistently seems to be the better option, better efficacy, less side effects. Abstr#1695 #ACR21 @RheumNow https://t.co/kLGr6pVnxQ
Robert B Chao, MD doctorRBC
3 years 1 month ago
Can we predict which PsO pts will develop PsA?
Machine learning and phenotyping of blood immune cell subsets identified an immune profile to discriminate PsO from PsA.
Abs#1774
#ACR21
@RheumNow
https://t.co/PERx86jjkJ https://t.co/oEpbMZ0nnK
TheDaoIndex KDAO2011
3 years 1 month ago
Congrats to Dr. Debaditya Roy, Dr. Chinenye Osuorji and Dr. Vaneet Sandhu on the leaderboard for engaged learning during #ACR21 @rheumnow
My points are pathetic compared to theirs and the top 10 https://t.co/yYppc029DM
Eric Dein ericdeinmd
3 years 1 month ago
#ACR21 Ab#L03: B cell depletors and #COVID19 vax:
⭐️B cell count <40 around vax had lower response to vax, than 40+ B-cell, independent of RTX or BEL
▶️ Timing of vax around B cell return can improve response
@Rheumnow https://t.co/1B7Bnb1QQu https://t.co/bKnfw6gD8O
Md Yuzaiful Md Yusof Yuz6Yusof
3 years 1 month ago
#ACR21 #Abstr1491 What’s new in skin #lupus aetiology? Paired skin & blood using scRNA-seq:
💠Nonlesional skin in CLE/SLE is IFN-I-riched
💠Lupus-enriched CD16+ DCs undergo robust IFN education in the skin & gained pro-inflammatory phenotypes @RheumNow https://t.co/70zrC4T7SB https://t.co/75HjvGmNTa
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