🔥Ignite Talk 10:20AM South Philly Stage🔥 abstract #0946 SLE, birth control, & pregnancy planning 🔥30% of women used no birth control despite only 17% voicing interest in pregnancy 🔥More 1/2 of women interested in pregnancy were not medically ready #ACR22 @RheumNow

Kahlenberg @Kahlenberglab et al. TYK2i deucravacitinib in SLE. Clinical efficacy (figure). Deucravacitinib suppressed IFN production, IFN-responsive gene expression, IFN-inducible proteins, B cell markers,serological biomarkers. @RheumNow #ACR22 Abstr#1000 https://t.co/zzkoPLOlSR https://t.co/znyG8N5pJ2

• Deucravacitinib Reduces Interferons, B Cell Pathways, and Serological Biomarker…

Severe non-adherence to HCQ independently assoc'd w/ risk of SLE flare in the following year, with early damage, and 5-year mortality. Abs 0343 #ACR22 @RheumNow https://t.co/JYRWD5QIlf https://t.co/UCWYrHIc4b

• Severe Non-adherence to Hydroxychloroquine Is Associated with Flares, Early Dam…

Gopal et al. Withdrawal of immunosuppressants non-inferior to steroid withdrawal in SLE in clinical remission. Numerically higher flare rate in steroid withdrawal group 15 vs 7 (RR 2.1). @RheumNow #ACR22 Abstr#0997 https://t.co/psoHvg0pVG https://t.co/GlsDjpgXGo

• Withdrawal of Maintenance Glucocorticoid versus Other Immunosuppressants Among …

Broder et al. HCQ alone vs steroid alone as maintenance in ESKD due to SLE. HCQ less cardiac events, less infection. @RheumNow #ACR22 Abstr#0539 https://t.co/mb3Eof2Uiv https://t.co/3i3ZTY25ru

• Cardiac Complications, Thrombosis, Infections and All-cause Mortality Among Pat…

Ab0676 #ACR22 Adrenal hemorrhage in APLS 59 pts from SLE cohort + 181 from lit review 65% prior VTE, 12% CVA, 24% OB morbidity 46% thrombocyt, 21% had SLE 58% on a/c 69% b/l hemorrhage 63% adrenal insuff Radiol remission: 6% at 1 yr, 41% at 5yr Death 2% 1 yr, 11% at 5 @RheumNow https://t.co/EacifcN7Sd

Ab0683 #ACR22 aPL Pts ANA pos vs neg: 521 pts with +aPL Ab WO other autoimmune disease 224 +ANA, 297 -ANA ANA+ ass w/ hemolytic anemia, thrombocyt, leukopenia, livedo, unexplained fetal death Trend for arthritis, aPL nephropathy @RheumNow https://t.co/3NHGymyL1C

Ab0674 #ACR22 HIT AND APLS?? Retrosp review of 23 pts treated for HIT in the hospital with APLS or SLE with aPL Ab: Not one ultimately met clinical criteria for HIT 1 pt had PF4 antibodies, SRA testing negative in ALL cases Thrombocytopenia w/ aPL Abs? Think APS 1st! @Rheumnow https://t.co/ZYZP5VZF0R