Drug Safety

TheDaoIndex KDAO2011
2 years 10 months ago
Dr. C Langford on #YearinReview: ORAL Surveillance noted NNH=16 in pts w/ASCVD compared to NNH 223 in pts w/o ASCVD. This led to FDA warning on all JAKi; how does not this apply to the new JAKi's? Discussion needed with patients when starting this class of drug #ACR22 @rheumnow https://t.co/XtJVap6yjh


Eric Dein ericdeinmd
2 years 10 months ago
Year in Review #acr22
Oral Surveillance:
With ASCVD number needed to harm 16, only 223 without ASCVD
Focus on risk stratification
@RheumNow https://t.co/tJyha1WKfR


Julian Segan JulianSegan
2 years 10 months ago
ORAL surveillance the big talking factor over the last year.
NNH of 16(!) for CV event (over 5 yrs) in those with history of atherosclerotic CV disease.
@RheumNow #ACR22 #yearinreview #ACRBest

Robert B Chao, MD doctorRBC
2 years 10 months ago
Great start to year in review.
Beginning with JAKinibs in the much talked about ORAL Surveillance study.
Good Review of the mechanisms of action for JAKinibs
@RheumNow #ACR22 https://t.co/IF0t4uSefj


Akhil Sood MD AkhilSoodMD
2 years 10 months ago
Abstr #0078
Ogdie et al found that
- Pts seen by rheumatologists more likely receive bDMARDs or csDMARDs
- Opiates & non-Opiate pain medications were more commonly prescribed to pts seen by PCPs alone
@RheumNow #ACR22
https://t.co/uDcOc0Nn3Y https://t.co/FeAq21fiVs

The management of RA patients with a history of cancer continues to be an area of concern. General recommendations are to treat patients with a history of solid organ cancer as no different to any other RA patient. Recently, the ORAL-Surveillance study demonstrated evidence of a greater risk of cancer with tofacitinib than with TNF inhibitors. In this setting, two posters both reassure and raise a new cause for concern.
A Japanese large scale claims data study was able to collect 5-year data to study the treatment patterns in Still’s. In May 2019, intravenous tocilizumab was approved in Japan for Still’s disease. The study was designed to see patterns of steroid exposure before and after the approval of this therapy.
The patient advocacy organization CreakyJoints will present 13 scientific posters at this year's ACR Convergence 2022 and 8 posters as part of the patient perspectives track. Below is a sampling of these scientific posters.
Priority Research Topics for Vaccine Uptake Among Adults with Autoimmune Conditions (Oral Presentation, Abstract 2247, Monday, November 14, 2022, 4:30-6:00pm ET)

TheDaoIndex KDAO2011
2 years 10 months ago
Did You Know? FDA relaxed warnings on #sarcoma with #Forteo- can use more than 2 years @RheumNow #acr22 #acrreview #osteoporosis https://t.co/Xzr6TZIlWN


TheDaoIndex KDAO2011
2 years 10 months ago
Drug holidays for #osteoporosis RX but be note fracture risk may increase with these holidays- consider an anabolic agent during these times - Dr Tanner #acr22 @RheumNow #acrreview https://t.co/6XbpYD5D1X


sheila RHEUMarampa
2 years 10 months ago
Dr Tanner presents the features of AFF👇
It is rare, subtrochanteric in location and often appears w/n 5-10 yrs of BP use.
#ACR22 @RheumNow #acrreview #osteoporosis https://t.co/KbMJ4dXfpj


TheDaoIndex KDAO2011
2 years 10 months ago
Withdrawing IL17i will more likely cause a relapse, but pts will respond when reintroduced -Dr Scher #PsA @rheumnow #acr22 #acrreview https://t.co/FvWVuQGJda

Rheumatoid arthritis treatment has come leaps and bounds in recent decades. Gone are the days of gold injections, chemical synovectomies, and physician-mandated bedrest (heaven forbid). Though the marketplace for RA treatments is becoming ever more crowded, there are still unmet needs.
The updated 2022 EULAR recommendations for the management of rheumatoid arthritis (RA) were initially presented by Dr. Josef Smolen at EULAR 2022, and are now in press delineating the most recent developments and perspectives in RA treatment.