Articles By Bella Mehta, MBBS, MS
LLM en el LES: de la educación del paciente al apoyo a la toma de decisiones clínicas
La aparición de los modelos lingüísticos grandes (LLM) representa un cambio prometedor en la forma en que se comunican e interpretan enfermedades complejas como el lupus eritematoso sistémico (LES) tanto en el entorno clínico como en el del paciente. Dos resúmenes de EULAR 2026 destacan el papel evolutivo de los LLM en todo este espectro, desde la educación orientada al paciente hasta el razonamiento diagnóstico.
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LLMs in SLE: From Patient Education to Clinical Decision Support
The emergence of large language models (LLMs) represents a promising shift in how complex diseases such as systemic lupus erythematosus (SLE) are communicated and interpreted across both patient and clinical settings. Two EULAR 2026 abstracts highlight the evolving role of LLMs across this spectrum, from patient-facing education to diagnostic reasoning.
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Novedades en el tratamiento del síndrome de activación macrofágica
El SAM, la complicación más grave de la enfermedad de Still, se reconoce cada vez más como un estado hiperinflamatorio impulsado por citocinas centrado en el interferón gamma (IFNγ). Los avances terapéuticos presentados en EULAR 2026 demuestran tanto la consolidación de las vías establecidas como la expansión hacia nuevas estrategias biológicas.
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What’s New in Macrophage Activation Syndrome Therapeutics
MAS, the most severe complication of Still’s disease, is increasingly recognized as a cytokine-driven hyperinflammatory state centered on interferon gamma (IFNγ). Therapeutic advances presented at EULAR 2026 demonstrate both consolidation of established pathways and expansion into novel biologic strategies.
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Del escepticismo a la reconsideración: resultados a 4 años de la terapia CAR-T en el lupus
Nuevos datos de seguimiento a 4 años de la terapia con células CAR-T en el LES grave y refractario muestran que los ocho pacientes alcanzaron una remisión clínica sostenida sin necesidad de inmunosupresión continua. Esto sugiere que la terapia CAR-T puede inducir un verdadero «reinicio inmunitario», lo que desafía el escepticismo inicial y plantea interrogantes sobre su posible uso en fases más tempranas de la enfermedad.
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From Skepticism to Reconsideration: 4‑Year CAR‑T Outcomes in Lupus
Chimeric antigen receptor (CAR) T‑cell therapy, long established in hematologic malignancies, is now emerging as a transformative approach in systemic lupus erythematosus (SLE), a disease historically managed with chronic immunosuppression.
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Deep Learning Model Accurately Detects Ankylosing Spondylitis on MRI
AI continues to move from research labs into rheumatology clinics, promising to reshape how inflammatory diseases are diagnosed and monitored. Ankylosing spondylitis, in particular, poses a diagnostic challenge—its early imaging findings are subtle, and radiographic changes may take years to appear and require specific musculoskeletal radiology expertise. A new deep learning model offers a glimpse into how AI could bridge this diagnostic gap.
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Bone Density in Ankylosing Spondylitis
Ankylosing spondylitis (AS) is a burden on the bones—both literally and diagnostically. The disease’s dual nature, marked by chronic inflammation and abnormal new bone formation, complicates the assessment of bone health.
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Beyond the Breakthrough: Equity and Access in CAR-T Cell Therapy for RA
At ACR Convergence 2025, abstract 1039 entitled, “Global Cost-Effectiveness and Equity in CAR-T Cell Therapy for Rheumatoid Arthritis” adds a critical dimension to the growing enthusiasm around cellular therapies in autoimmune disease.
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Pregnancy in SLE: Risks Extend Beyond Clinical Concerns
While clinical comorbidities such as lupus nephritis, hypertension, and thrombocytopenia have traditionally dominated risk assessments, new findings presented at EULAR 2025 spotlight the critical—and often underrecognized—role of social determinants of health (SDOH) in shaping maternal outcomes.
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