#SLE treatments #ACR24: Compared efficacy & safety of belimumab vs. telitacicept (targets B-lymphocyte stimulator (BLyS) and proliferation-inducing ligand(APRIL)) Both improved disease activity with no difference in efficacy Belimumab had lower infection rates @RheumNow abst1544

More data from PAISLEY, deucravacitinib in SLE Small but significant benefit w/respect to joints, a little disappointing tbh Would like to see this for all manifestations ie pericarditis, pleuritis, etc Anyone have an infographic or useful chart? #ACR20 @RheumNow Abstr#1552 https://t.co/tXUoUtssxo

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• https://x.com/EBRheum/status/1858206970785706213/photo/1

Low uptake of SGLT2i in Lupus nephritis SGLT2i users had similar adverse event rates as ACEi/ARB users SGLT2i users experienced more weight loss #ACR24 @rheumnow abst#1534 https://t.co/tB5o7tyhu5

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Study on SLE and NMO overlap: Higher risk of acute cystitis & severe sepsis in hospitalized patients SLE/NMO overlap patients 3x more likely to develop acute cystitis 2x more likely to develop severe sepsis #ACR24 @RheumNow abst#1529

Study on SLE treatments: Compared adverse events of anifrolumab vs. belimumab Similar risks for mortality, sepsis, herpes zoster, dialysis, MACE, PE/VTE, COVID-19, URI, pneumonia, and mental illness #ACR24 @RheumNow abst#1527

Study on severe lymphopenia in SLE: - Assessed incidence, risk factors, and outcomes - 11.52% of SLE patients experienced severe lymphopenia - Higher infection rates during severe lymphopenia period = No opportunistic infections observed #ACR24 abst#1519 @rheumnow @HSSProfEd

Study on pregnancy outcomes in SLE with thrombocytopenia: Higher disease activity, pregnancy loss, and stillbirth rates Identified risk factors: Anti-β2GP-I positivity and higher SLEDAI score #ACR24 abst#1487 @RheumNow

Study on cardiovascular deaths in SLE: - Analyzed 1999-2020 data - Overall decline in mortality rates, but recent increase since 2014 - Higher rates in women and African Americans - Geographic disparities noted #ACR24 abst#0998 @rheumnow https://t.co/dpjsl0gI0x

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How do we prevent SLE flares requiring steroids? Petri: Background medication! HCQ adherence is key -check WB levels to measure EULAR recs early addition of immunosuppress/biols “Taper quickly, withdraw slowly” Come down quick, then slowly off @RheumNow #ACR24 @jhrheumatology

Petri recommends IM triamcinolone as safer than prednisone dosing per FLOAT trial, decreased risk of fx @RheumNow #ACR24 @jhrheumatology https://t.co/vhMRdSkBAA https://t.co/novlGcss6x

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• https://twitter.com/ericdeinmd/status/1858178815727739128

How do you treat a flare of SLE with steroids? @RheumNow #ACR24

Petri: 5 mg prednisone or less is our standard for lupus control EULAR 23 recs - early addition of immunosuppressant and/or biologics instead to prevent steroids @RheumNow #ACR24 @jhrheumatology https://t.co/jhxEeboPu5

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• https://x.com/ericdeinmd/status/1858178495269974066/photo/1

Reset the bar for remission (off steroids)!! Session #17S19 3% higher risk of organ damage for each 1mg of pred Remission possible in rheum with lower dose GC regimen and faster taper #GCStewardship #ACR24 @RheumNow @BethIWallace

Single centre experience of belimumab at @GSTTnhs @RheumNow #ACR24 https://t.co/c4jlEPRwen

• https://twitter.com/sahilja09303150/status/1858168844587598111

Petri on Steroids in SLE Steroid-related organ damage presents later - organ damage is higher in African-Americans Dose response for prednisone and CVD risk Each 1 mg prednisone = 3% increase risk in organ damage! #ACR24 @jhrheumatology @RheumNow https://t.co/00S1mxrXJp

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• https://x.com/ericdeinmd/status/1858177175750349255/photo/1