Low uptake of SGLT2i in Lupus nephritis SGLT2i users had similar adverse event rates as ACEi/ARB users SGLT2i users experienced more weight loss #ACR24 @rheumnow abst#1534 https://t.co/tB5o7tyhu5

• https://x.com/bella_mehta/status/1858207474039292036/photo/1

Study on SLE and NMO overlap: Higher risk of acute cystitis & severe sepsis in hospitalized patients SLE/NMO overlap patients 3x more likely to develop acute cystitis 2x more likely to develop severe sepsis #ACR24 @RheumNow abst#1529

Study on SLE treatments: Compared adverse events of anifrolumab vs. belimumab Similar risks for mortality, sepsis, herpes zoster, dialysis, MACE, PE/VTE, COVID-19, URI, pneumonia, and mental illness #ACR24 @RheumNow abst#1527

Study on severe lymphopenia in SLE: - Assessed incidence, risk factors, and outcomes - 11.52% of SLE patients experienced severe lymphopenia - Higher infection rates during severe lymphopenia period = No opportunistic infections observed #ACR24 abst#1519 @rheumnow @HSSProfEd

Study on pregnancy outcomes in SLE with thrombocytopenia: Higher disease activity, pregnancy loss, and stillbirth rates Identified risk factors: Anti-β2GP-I positivity and higher SLEDAI score #ACR24 abst#1487 @RheumNow

Study on cardiovascular deaths in SLE: - Analyzed 1999-2020 data - Overall decline in mortality rates, but recent increase since 2014 - Higher rates in women and African Americans - Geographic disparities noted #ACR24 abst#0998 @rheumnow https://t.co/dpjsl0gI0x

• https://x.com/bella_mehta/status/1858209991041466428/photo/1
• https://x.com/bella_mehta/status/1858209991041466428/photo/1

How do we prevent SLE flares requiring steroids? Petri: Background medication! HCQ adherence is key -check WB levels to measure EULAR recs early addition of immunosuppress/biols “Taper quickly, withdraw slowly” Come down quick, then slowly off @RheumNow #ACR24 @jhrheumatology

Petri recommends IM triamcinolone as safer than prednisone dosing per FLOAT trial, decreased risk of fx @RheumNow #ACR24 @jhrheumatology https://t.co/vhMRdSkBAA https://t.co/novlGcss6x

• https://x.com/ericdeinmd/status/1858179254606844049/photo/1
• https://twitter.com/ericdeinmd/status/1858178815727739128

How do you treat a flare of SLE with steroids? @RheumNow #ACR24

Petri: 5 mg prednisone or less is our standard for lupus control EULAR 23 recs - early addition of immunosuppressant and/or biologics instead to prevent steroids @RheumNow #ACR24 @jhrheumatology https://t.co/jhxEeboPu5

• https://x.com/ericdeinmd/status/1858178495269974066/photo/1
• https://x.com/ericdeinmd/status/1858178495269974066/photo/1