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Drug Safety

      Serrano-Combarro et al. Abatacept in RA-ILD. 343 patients. In 23.3% ILD progressed on abatacept. Is that good or bad? We

      Richard Conway RichardPAConway

      10 months 3 weeks ago
      Serrano-Combarro et al. Abatacept in RA-ILD. 343 patients. In 23.3% ILD progressed on abatacept. Is that good or bad? We need comparative studies! @RheumNow #ACR24 Abstr#0475 https://t.co/nUEDdjGguA https://t.co/sXEF72MafK
      Are you pts using cannabis?
      In Canada - 20% reported using w/in past 2 years
      Use for pain, sleep, anxiety
      78% noted effi

      Eric Dein ericdeinmd

      10 months 3 weeks ago
      Are you pts using cannabis? In Canada - 20% reported using w/in past 2 years Use for pain, sleep, anxiety 78% noted efficacy Compare to another study said 57% stopped due to inefficacy, 28% AEs - very diff result 70% did not tell their doc 16S18 @BharatKumarMD #ACR24 @RheumNow https://t.co/6NAECW5MJK
      Serrano-Combarro et al. Baricitinib in RA-ILD . 72 patient case series. PFTs in picture. HRCT stable/improved in 72% ove

      Richard Conway RichardPAConway

      10 months 3 weeks ago
      Serrano-Combarro et al. Baricitinib in RA-ILD . 72 patient case series. PFTs in picture. HRCT stable/improved in 72% over 24 months. Dyspnoea stable/improved in 90%. @RheumNow #ACR24 Abstr#0476 https://t.co/aVI2kRZkMN https://t.co/4l5GKsFKtm
      For many years glucocorticoids were the mainstay of our treatment of granulomatosis with polyangiitis (GPA). The paradigm shifted with cyclophosphamide and then again with rituximab, and we used less steroids, but we still used lots. Avacopan teased the demise of steroids, but in the trial they, and now we, still use them. Glucocorticoids are our old trusty friend, our comfort blanket. But no more! Good riddance to the medication with the
      Pharmacologics:
      Cannabis absorption and metabolism is variable
      Inhaled absorption 10-35%
      THC is 97% protein bound, lipo

      Eric Dein ericdeinmd

      10 months 3 weeks ago
      Pharmacologics: Cannabis absorption and metabolism is variable Inhaled absorption 10-35% THC is 97% protein bound, lipophilic and deposits in fat and spleen Liver function is critical for THC metabolism 16S18 @BharatKumarMD #ACR24 @RheumNow
      Quinn @KQuinnRheum @petercgrayson et al. FDG-PET is not particularly useful in monitoring GCA on tocilizumab. Toc reduce

      Richard Conway RichardPAConway

      10 months 3 weeks ago
      Quinn @KQuinnRheum @petercgrayson et al. FDG-PET is not particularly useful in monitoring GCA on tocilizumab. Toc reduces but often not eliminate PET inflammation. PET activity does not predict relapse or vascular progression @RheumNow #ACR24 Abstr#0742 https://t.co/1qcJCGV118 https://t.co/6mBCgcbYo6
      Harkins @DrTrishHarkins et al. Serum disease activity markers in PMR. ROC analysis for active vs remission - fibrinogen

      Richard Conway RichardPAConway

      10 months 3 weeks ago
      Harkins @DrTrishHarkins et al. Serum disease activity markers in PMR. ROC analysis for active vs remission - fibrinogen (1.000), ESR (0.986), Haptoglobin (0.976), CRP (0.986), ALP (0.854). @RheumNow #ACR24 Abstr#0741 https://t.co/f8cX68Ov9Y https://t.co/zp5c7aQwxr
      Dunn et al. Are the medications recommended for RA-ILD by the ACR guidelines used in the real-world. NO! 4108 RA-ILD pat

      Richard Conway RichardPAConway

      10 months 3 weeks ago
      Dunn et al. Are the medications recommended for RA-ILD by the ACR guidelines used in the real-world. NO! 4108 RA-ILD patients. Only 12% on one of the first line recommended therapies! @RheumNow #ACR24 Abstr#0214 https://t.co/OzW90OA1Vd https://t.co/S1MKmEDrLF
      Bimekizumab (BKZ) is a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)‑17A and F. There have been more updates on the 2 year data on BKZ at #ACR24, and this is a summary of four studies being presented this year at ACR24.
      How to take cannabis?
      Do NOT rec inhaled
      - makes drug level go up high/fast, benefit for rec use but not for medicinal
      -

      Eric Dein ericdeinmd

      10 months 3 weeks ago
      How to take cannabis? Do NOT rec inhaled - makes drug level go up high/fast, benefit for rec use but not for medicinal - bronchitis, ?oral cancer Other risks: psychosis - risk in youth, memory loss (poor studies), dependence, respiratory if inhaled Clauw 16S18 #ACR24 @RheumNow https://t.co/coYNl7VOT3
      TAPIR study of continuing vs stopping steroids in ANCA vasculitis in remission. Relapse at month 6 in 16% vs 4%. OR 4.22

      Richard Conway RichardPAConway

      10 months 3 weeks ago

      TAPIR study of continuing vs stopping steroids in ANCA vasculitis in remission. Relapse at month 6 in 16% vs 4%. OR 4.22, but low rate in either group. If treated Rituximab, no difference! Merkel et al. @RheumNow #ACR24 Abstr#0774 #ACRbest https://t.co/pKa4U5L2fW https://t.co/MjzE14SeGi

      The rising placebo response rates in PsA trials are linked to global recruiting patterns, with more studies in less affl

      Antoni Chan MD (Prof) synovialjoints

      10 months 3 weeks ago
      The rising placebo response rates in PsA trials are linked to global recruiting patterns, with more studies in less affluent countries. Limited access to healthcare may drive this trend, highlighting the need for awareness among stakeholders. Plenary Abstr#0722… https://t.co/FplpSlIamR https://t.co/NIp76IS6TZ
      Which immunomodulators dampen recombinant zoster vaccine immunogenicity?

      In this 🇧🇷 study in autoimmune dx patien

      David Liew drdavidliew

      10 months 3 weeks ago
      Which immunomodulators dampen recombinant zoster vaccine immunogenicity? In this 🇧🇷 study in autoimmune dx patients, overrepresented in non-responders are: - rituximab pts - 'combined therapy' strategies needed for them but reassuring for the others! #ACR24 ABST0248 @RheumNow https://t.co/he1ICa9WZg
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