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      Gladman et al. PsA patients treated with guselkumab in DISCOVER-2. Male patients had more radiographic progression. Male

      Richard Conway RichardPAConway

      4 months 1 week ago
      Gladman et al. PsA patients treated with guselkumab in DISCOVER-2. Male patients had more radiographic progression. Males exhibit stronger relationship between early joint response and lower subsequent rates radiographic progression. @RheumNow #ACR25 Abstr#2345 https://t.co/TSNwesvPzj
      Mulcaire-Jones et al. Changes in PFTs over 1 year in early RA. Improved 31%, worsened 25%. No difference based on baseli

      Richard Conway RichardPAConway

      4 months 1 week ago
      Mulcaire-Jones et al. Changes in PFTs over 1 year in early RA. Improved 31%, worsened 25%. No difference based on baseline disease activity, or MTX use. Those with baseline ILD were MORE likely to improve. ?due to effect of treatment @RheumNow #ACR25 Abstr#2235 https://t.co/bJeLYN9oN7
      EGPA relapse in MANDARA including OLE

      Majority of relapses are asthma / sinonasal in nature

      Of non-airway:
      - arthralgi

      Brian Jaros, MD Dr_Brian_MD

      4 months 1 week ago
      EGPA relapse in MANDARA including OLE Majority of relapses are asthma / sinonasal in nature Of non-airway: - arthralgia/myalgia - sensory peripheral neuropathy @RheumNow #ACR25 Abst1769 https://t.co/cPjjzl4RWS
      CAR T flex for myositis 💪LB14: Ongoing Phase 1 CD19 CAR T in refractory myositis✅ Well-tolerated (low-grade CRS,

      Akhil Sood MD, MS AkhilSoodMD

      4 months 1 week ago

      CAR T flex for myositis 💪 LB14: Ongoing Phase 1 CD19 CAR T in refractory myositis ✅ Well-tolerated (low-grade CRS, transient cytopenias) 📈 11/11 improved MMT-8 (median +22 Day 85, +27 Day 169) 🔹 10/11 off myositis therapy at follow-up @RheumNow #ACR25 https://t.co/btOsIcHe0f

      Punjadath et al. Predictors of progression palindromic rheumatism to RA. 30 patients. 47% progressed to RA. Total number

      Richard Conway RichardPAConway

      4 months 1 week ago
      Punjadath et al. Predictors of progression palindromic rheumatism to RA. 30 patients. 47% progressed to RA. Total number of joints involved, RF, CRP predicted progression univariate. Only total joints significant in mutlivariate but underpowered. @RheumNow #ACR25 Abstr#2261 https://t.co/FtVKdGtEr9
      Late Breaker: Phase 2 RCT of low dose IL2 in SLE

      Dose dependent response in SRI4 over 12 weeks
      & surprisingly high

      Mike Putman EBRheum

      4 months 1 week ago
      Late Breaker: Phase 2 RCT of low dose IL2 in SLE Dose dependent response in SRI4 over 12 weeks & surprisingly high rates of LLDAS Too early to know if useful, but worth evaluating in a phase 3 #ACR25 @RheumNow Abstr#LB01 https://t.co/oPOLG82nwi
      Can fiber make methotrexate work better? (LB15)

      In a placebo-controlled Superfibers RCT, inulin 12 g/day improved EULAR

      Jiha Lee JihaRheum

      4 months 1 week ago
      Can fiber make methotrexate work better? (LB15) In a placebo-controlled Superfibers RCT, inulin 12 g/day improved EULAR response & Th17/Treg ratio in RA among MTX users. @RheumNow #ACR25 https://t.co/awMRNloNw5
      Late breaking: secukinumab out-performs ustekinumab in PsA pt who have failed TNF therapy

      RCT of 119 pt
      57.1% response

      Brian Jaros, MD Dr_Brian_MD

      4 months 1 week ago
      Late breaking: secukinumab out-performs ustekinumab in PsA pt who have failed TNF therapy RCT of 119 pt 57.1% response at wk 28 in SEC 27% response at wk 28 in UST Numerically lower adverse events leading to d/c in SEC @RheumNow #ACR25 #ACRBest Abst LB06 https://t.co/wDxtscP2ku
      Does fiber boost MTX efficacy?
      LB15: Fiber + MTX led to
      📉 Greater drop in DAS28 (–1.00 vs –0.34 placebo)
      🧬 ↓

      Akhil Sood MD, MS AkhilSoodMD

      4 months 1 week ago
      Does fiber boost MTX efficacy? LB15: Fiber + MTX led to 📉 Greater drop in DAS28 (–1.00 vs –0.34 placebo) 🧬 ↓ Th17 cells & Th17/Treg ratio Some food for thought @RheumNow #ACR25 https://t.co/VhLVP1nRy2
      Serrano-Combarro et al. Baricitinib in RA-ILD. Observational, 42 patients. Progressive ILD in 26%. More frequent in wome

      Richard Conway RichardPAConway

      4 months 1 week ago
      Serrano-Combarro et al. Baricitinib in RA-ILD. Observational, 42 patients. Progressive ILD in 26%. More frequent in women. @RheumNow #ACR25 Abstr#2229 https://t.co/ZXfgxKoau7
      Benson et al. Clinical features that predict CV risk in PsA. Median 3.53 year follow up. 56 CV events. 766 patients. Dac

      Richard Conway RichardPAConway

      4 months 1 week ago
      Benson et al. Clinical features that predict CV risk in PsA. Median 3.53 year follow up. 56 CV events. 766 patients. Dactylitis emerged as key predictor in adjusted models. @RheumNow #ACR25 Abstr#2317 https://t.co/5O3G7vGYbq
      Cutaneous vasculitis: who is most likely to have systemic disease?

      430 pt w skin vasculitis examined in case-control

      A

      Brian Jaros, MD Dr_Brian_MD

      4 months 1 week ago
      Cutaneous vasculitis: who is most likely to have systemic disease? 430 pt w skin vasculitis examined in case-control Associated with risk for systemic vasculitis/CTD: - GI sx - ulcerating/necrotic lesions - constitutional sx - hematuria @RheumNow #ACR25 Abst 2525 https://t.co/lRjLKRYxDW
      How great would it be to have a diagnostic RA-ILD Urine Dipstick?

      Small cohort 14 RA-ILD vs. 64 RA no ILD
      Urine ILDScor

      Aurelie Najm AurelieRheumo

      4 months 1 week ago
      How great would it be to have a diagnostic RA-ILD Urine Dipstick? Small cohort 14 RA-ILD vs. 64 RA no ILD Urine ILDScore includes 2 proteins SPOCK1 and PGRMC1 Independently asso with ILD w/ OR 6.19 Urine ILD score alone AUC 0.9 ILD urine score + clinical data AUC = 0.95 Needs https://t.co/7PqX8kdjKJ
      To be continued (or discontinued?):Abstract 2360: Compared to TNFi, IL-17i & JAKi users had🔹 Higher odds of med

      Akhil Sood MD, MS AkhilSoodMD

      4 months 1 week ago

      To be continued (or discontinued?): Abstract 2360: Compared to TNFi, IL-17i & JAKi users had 🔹 Higher odds of med switching <180 days 🔹 Shorter time to discontinuation @RheumNow #ACR25 #axSpA https://t.co/IOHaFSJqHn

      Interesting study evaluating the "CALLY" index (serum albumin × lymphocyte count / CRP / 10,000) for predicing mortal

      Mike Putman EBRheum

      4 months 1 week ago
      Interesting study evaluating the "CALLY" index (serum albumin × lymphocyte count / CRP / 10,000) for predicing mortality in AAV I typically dislike these because (1) they are often cumbersome to calculate & (2) they often perform poorly This one piqued my interest; pretty https://t.co/ziroQOH5Cq
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