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      Late Breaker: Phase 2 RCT of low dose IL2 in SLE

      Dose dependent response in SRI4 over 12 weeks
      & surprisingly high

      Mike Putman EBRheum

      1 week 2 days ago
      Late Breaker: Phase 2 RCT of low dose IL2 in SLE Dose dependent response in SRI4 over 12 weeks & surprisingly high rates of LLDAS Too early to know if useful, but worth evaluating in a phase 3 #ACR25 @RheumNow Abstr#LB01 https://t.co/oPOLG82nwi
      Can fiber make methotrexate work better? (LB15)

      In a placebo-controlled Superfibers RCT, inulin 12 g/day improved EULAR

      Jiha Lee JihaRheum

      1 week 2 days ago
      Can fiber make methotrexate work better? (LB15) In a placebo-controlled Superfibers RCT, inulin 12 g/day improved EULAR response & Th17/Treg ratio in RA among MTX users. @RheumNow #ACR25 https://t.co/awMRNloNw5
      Late breaking: secukinumab out-performs ustekinumab in PsA pt who have failed TNF therapy

      RCT of 119 pt
      57.1% response

      Brian Jaros, MD Dr_Brian_MD

      1 week 2 days ago
      Late breaking: secukinumab out-performs ustekinumab in PsA pt who have failed TNF therapy RCT of 119 pt 57.1% response at wk 28 in SEC 27% response at wk 28 in UST Numerically lower adverse events leading to d/c in SEC @RheumNow #ACR25 #ACRBest Abst LB06 https://t.co/wDxtscP2ku
      Does fiber boost MTX efficacy?
      LB15: Fiber + MTX led to
      📉 Greater drop in DAS28 (–1.00 vs –0.34 placebo)
      🧬 ↓

      Akhil Sood MD, MS AkhilSoodMD

      1 week 2 days ago
      Does fiber boost MTX efficacy? LB15: Fiber + MTX led to 📉 Greater drop in DAS28 (–1.00 vs –0.34 placebo) 🧬 ↓ Th17 cells & Th17/Treg ratio Some food for thought @RheumNow #ACR25 https://t.co/VhLVP1nRy2
      Serrano-Combarro et al. Baricitinib in RA-ILD. Observational, 42 patients. Progressive ILD in 26%. More frequent in wome

      Richard Conway RichardPAConway

      1 week 2 days ago
      Serrano-Combarro et al. Baricitinib in RA-ILD. Observational, 42 patients. Progressive ILD in 26%. More frequent in women. @RheumNow #ACR25 Abstr#2229 https://t.co/ZXfgxKoau7
      Benson et al. Clinical features that predict CV risk in PsA. Median 3.53 year follow up. 56 CV events. 766 patients. Dac

      Richard Conway RichardPAConway

      1 week 2 days ago
      Benson et al. Clinical features that predict CV risk in PsA. Median 3.53 year follow up. 56 CV events. 766 patients. Dactylitis emerged as key predictor in adjusted models. @RheumNow #ACR25 Abstr#2317 https://t.co/5O3G7vGYbq
      Cutaneous vasculitis: who is most likely to have systemic disease?

      430 pt w skin vasculitis examined in case-control

      A

      Brian Jaros, MD Dr_Brian_MD

      1 week 2 days ago
      Cutaneous vasculitis: who is most likely to have systemic disease? 430 pt w skin vasculitis examined in case-control Associated with risk for systemic vasculitis/CTD: - GI sx - ulcerating/necrotic lesions - constitutional sx - hematuria @RheumNow #ACR25 Abst 2525 https://t.co/lRjLKRYxDW
      How great would it be to have a diagnostic RA-ILD Urine Dipstick?

      Small cohort 14 RA-ILD vs. 64 RA no ILD
      Urine ILDScor

      Aurelie Najm AurelieRheumo

      1 week 2 days ago
      How great would it be to have a diagnostic RA-ILD Urine Dipstick? Small cohort 14 RA-ILD vs. 64 RA no ILD Urine ILDScore includes 2 proteins SPOCK1 and PGRMC1 Independently asso with ILD w/ OR 6.19 Urine ILD score alone AUC 0.9 ILD urine score + clinical data AUC = 0.95 Needs https://t.co/7PqX8kdjKJ
      To be continued (or discontinued?):Abstract 2360: Compared to TNFi, IL-17i & JAKi users had🔹 Higher odds of med

      Akhil Sood MD, MS AkhilSoodMD

      1 week 2 days ago

      To be continued (or discontinued?): Abstract 2360: Compared to TNFi, IL-17i & JAKi users had 🔹 Higher odds of med switching <180 days 🔹 Shorter time to discontinuation @RheumNow #ACR25 #axSpA https://t.co/IOHaFSJqHn

      Interesting study evaluating the "CALLY" index (serum albumin × lymphocyte count / CRP / 10,000) for predicing mortal

      Mike Putman EBRheum

      1 week 2 days ago
      Interesting study evaluating the "CALLY" index (serum albumin × lymphocyte count / CRP / 10,000) for predicing mortality in AAV I typically dislike these because (1) they are often cumbersome to calculate & (2) they often perform poorly This one piqued my interest; pretty https://t.co/ziroQOH5Cq
      Meta-analysis of 3 RCTs (n=1990) shows IL-17i offers comparable joint response but superior skin clearance vs adalimumab

      Antoni Chan MD (Prof) synovialjoints

      1 week 2 days ago
      Meta-analysis of 3 RCTs (n=1990) shows IL-17i offers comparable joint response but superior skin clearance vs adalimumab in biologic-naive PsA. IL-17i also had fewer discontinuations due to adverse events. Supports sequencing of biologics through different mechanisms of action in https://t.co/SJgFUMxWVb
      IgG4-RD continues to present in new and unusual ways

      Hasbani et al. report 9 IgG4-RD patients with coronary artery invo

      Brian Jaros, MD Dr_Brian_MD

      1 week 2 days ago
      IgG4-RD continues to present in new and unusual ways Hasbani et al. report 9 IgG4-RD patients with coronary artery involvement RCA and LAD most affected Seen on CTA Majority received RTX 7/9 pt at least partially improved imaging on f/u @RheumNow #ACR25 Abst 2531 https://t.co/Na0gdq3dgb
      A new genetic score for ILD prediction! 🫁

      Developed in the Veterans RA cohort and Validation in a Swedish cohort

      Mo

      Aurelie Najm AurelieRheumo

      1 week 2 days ago
      A new genetic score for ILD prediction! 🫁 Developed in the Veterans RA cohort and Validation in a Swedish cohort Model using classic RA-ILD risk factors and a cocktail of genetic risk A cut off of 0.05 in this cohort would exclude 36% from HRCT or PFTs Good performance https://t.co/6UsoSQAtyK
      RESET-RA, RCT of vagus nerve stim (device that zaps pts in neck)

      Marginal improvements in ACR20 at wk 12; trend in to i

      Mike Putman EBRheum

      1 week 2 days ago
      RESET-RA, RCT of vagus nerve stim (device that zaps pts in neck) Marginal improvements in ACR20 at wk 12; trend in to improvement in unblinded part of study fwiw Have never seen result that is more likely to be driven by plbo effect & unblinding 🤪 @RheumNow #ACR25 Abstr#2278 https://t.co/BlR570nv7k
      Hindosh et al. Semaglutide associated with reduced synovitis, joint pain and swelling, in RA. @RheumNow #ACR25 Abstr#228

      Richard Conway RichardPAConway

      1 week 2 days ago
      Hindosh et al. Semaglutide associated with reduced synovitis, joint pain and swelling, in RA. @RheumNow #ACR25 Abstr#2286 https://t.co/6Xs4um5l32
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