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      #ACR25 Abstr#1537 Beyond T-cell malignancy, we should be vigilant re: Local immune effector cell-associated toxicity syn

      Md Yuzaiful Md Yusof Yuz6Yusof

      1 week 4 days ago

      #ACR25 Abstr#1537 Beyond T-cell malignancy, we should be vigilant re: Local immune effector cell-associated toxicity syndrome (LICATS) with CAR-T. - Mostly afect skin & kidneys - Med time of onset 10 days; duration 11 days -Most LICATS were mild & without sequelae @RheumNow https://t.co/EnAWL936oh

      AOSD And sJIA aren't the same disease!!!. Another take on this by Scott Canna..because the clinical syndrome might have

      Bella Mehta bella_mehta

      1 week 4 days ago
      AOSD And sJIA aren't the same disease!!!. Another take on this by Scott Canna..because the clinical syndrome might have somethings distinct!! #acr25 @RheumNow
      Dr. Gensler gave a fantastic talk on SpA mimics
      ☝️Not all IBP is axSpA - interpret in the appropriate context + ima

      sheila RHEUMarampa

      1 week 4 days ago
      Dr. Gensler gave a fantastic talk on SpA mimics ☝️Not all IBP is axSpA - interpret in the appropriate context + imaging WOF other mimics 🔸 Sacral insufficiency fractures 🔸 Infections 🔸DISH #ACR25 @RheumNow https://t.co/7TIqyp5rYe
      In a Brazilian cohort (n=791), axSpA diagnosis delay dropped from 41.7 yrs (1960s) to 1.9 yrs (2020s). Female representa

      Antoni Chan MD (Prof) synovialjoints

      1 week 4 days ago
      In a Brazilian cohort (n=791), axSpA diagnosis delay dropped from 41.7 yrs (1960s) to 1.9 yrs (2020s). Female representation rose to 50%. Non-radiographic axSpA now 16.7%. MRI and updated criteria driving earlier, more equitable recognition. Abstract#1407 @RheumNow #ACR25 https://t.co/8hIpX0a1Sa
      RheumNow’s expanded coverage of the #ACR25 annual meeting is sponsored by Bristol Myers Squibb, Novartis, and UCB. All

      Dr. John Cush RheumNow

      1 week 4 days ago
      RheumNow’s expanded coverage of the #ACR25 annual meeting is sponsored by Bristol Myers Squibb, Novartis, and UCB. All coverage content is independently selected by RheumNow & its faculty.
      Who talks to their neighbour?
      +SSA / Ro talk differently to nearby cells in #SjD #salivary #glands vs NEG Ro SjD

      Ro52 a

      Janet Pope Janetbirdope

      1 week 4 days ago
      Who talks to their neighbour? +SSA / Ro talk differently to nearby cells in #SjD #salivary #glands vs NEG Ro SjD Ro52 acts differently than Ro60 ?implications for Rx response? 🤷‍♀️ #ACR25 @RheumNow @ACRheum #Sjogren’s Abst#1684 #ACRBest! Elegant work from Sara McCoy https://t.co/UWUKAxi0UW
      How many patients do you need to treat to prevent one RA conversion in at-risk individuals?

      APPIPRA and ALTO Intercepti

      Aurelie Najm AurelieRheumo

      1 week 4 days ago
      How many patients do you need to treat to prevent one RA conversion in at-risk individuals? APPIPRA and ALTO Interception studies, long term data Number Necessary to Treat to prevent 1 RA conversion across time: 1yr = 4 2yrs = 7 3, 4, 5 yrs = 9 6 yrs = 11 #ACR25 #ABSTRACT1678 https://t.co/GBzUJG8jVk
      DYK?
      A bipartite ilium is a common SIJ variant.
      More common among women.

      SpA mimics involving biomechanical stress:

      sheila RHEUMarampa

      1 week 4 days ago
      DYK? A bipartite ilium is a common SIJ variant. More common among women. SpA mimics involving biomechanical stress: BME & sclerosis 🔸OCI - assoc w/ multiparity, obesity 🔸Degenerative dse #ACR25 @RheumNow https://t.co/IoZepAJKJ6
      So who with inflamm arthralgias might benefit from abatacept, in terms of delaying RA onset?

      ALTO study (APIPPRA contin

      David Liew drdavidliew

      1 week 4 days ago
      So who with inflamm arthralgias might benefit from abatacept, in terms of delaying RA onset? ALTO study (APIPPRA continuation) 1y abatacept then follow If autoAb x5 (RF, ACPA IgG, IgA, anti-CarP, AAPA): sustained delay of RA If not: benefit only on Rx #ACR25 ABST1678 @RheumNow https://t.co/3Pc5ZLzVf6
      #ACR25 Abstr#1401 Sjogren’s #SjD is definitely not a benign disease! Real world study using US database showed high di

      Md Yuzaiful Md Yusof Yuz6Yusof

      1 week 4 days ago
      #ACR25 Abstr#1401 Sjogren’s #SjD is definitely not a benign disease! Real world study using US database showed high disease burden within 12 mths of diagnosis (i.e. healthcare resource use). GC use was high (~50%). Better therapy is needed to improve outcomes @RheumNow https://t.co/MI3vQ5LByr
      TNFi induction first year in RA leads to:
      - less D2T RA at 5y
      - more sustained remission from 10y onward
      - less DMARD ut

      David Liew drdavidliew

      1 week 4 days ago
      TNFi induction first year in RA leads to: - less D2T RA at 5y - more sustained remission from 10y onward - less DMARD utilization - less healthcare utilization in these real-world matched cohorts given biosimilar prices, this might be worth considering #ACR25 ABST1677 @RheumNow https://t.co/uL9nHtLkXZ
      Early TNFi treatment leads to

      -Less D2T at 5 yrs
      -More sustained remission at 10yrs
      -Less bDMARD escalation at 5yrs
      -M

      Aurelie Najm AurelieRheumo

      1 week 4 days ago
      Early TNFi treatment leads to -Less D2T at 5 yrs -More sustained remission at 10yrs -Less bDMARD escalation at 5yrs -More DMARD free remission at 5yrs and 10 yrs -20% reduction annual healths costs -11 mo delay in ttmt escalation Safety data were not presented #ACR25 https://t.co/jPMGUGPtqP
      SELECT-COMPARE RA UPA vs. ADA

      What do we learn from 7 years data? Not much

      Patients who did well on the first drug, ke

      Aurelie Najm AurelieRheumo

      1 week 4 days ago
      SELECT-COMPARE RA UPA vs. ADA What do we learn from 7 years data? Not much Patients who did well on the first drug, keep doing well Patients who required switching for primary failure don't do as well, w/ 26% pts reaching DAS remission in UPA + MTX vs. 16% in ADA + MTX gp No https://t.co/JLUTRZuZOm
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