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      #Deucravacitinib #Tyk2i in active #PsA to 52weeks
      #PBO was crossed over at 16weeks

      Ongoing improvement for high bar out

      Janet Pope Janetbirdope

      11 months ago
      #Deucravacitinib #Tyk2i in active #PsA to 52weeks #PBO was crossed over at 16weeks Ongoing improvement for high bar outcomes ex % in #minimal #disease #activity #MDA #Xray #progression was reduced with real data (not imputed) #ACR2025 @RheumNow @ACRheum https://t.co/kAMym2x8HQ
      Abstract 2687: GLP-1 RA in PsA
      In combined Toronto + NYU cohort, GLP-1 RA significantly associated with reduced:
      - Weig

      Akhil Sood MD, MS AkhilSoodMD

      11 months ago
      Abstract 2687: GLP-1 RA in PsA In combined Toronto + NYU cohort, GLP-1 RA significantly associated with reduced: - Weight, CRP, and pain scores - Each 1% reduction in body weight associated w/ TJC, DAPSA, EQ-5D (QoL), LDL, Systolic BP @RheumNow #ACR25 https://t.co/30lPDkALKs
      McDermott et al. Target trial emulation of different b/tsDMARDs in RA-ILD. RTX as SOC. No significant differences seen i

      Richard Conway RichardPAConway

      11 months ago
      McDermott et al. Target trial emulation of different b/tsDMARDs in RA-ILD. RTX as SOC. No significant differences seen in hospitalisation or death. Trends to abatacept and JAKi looking better... @RheumNow #ACR25 Abstr#2662 #ACRBest https://t.co/ghHEKztvgz
      #PD1 Ab looks good and safe in active RA

      Rosnilimab, a Selective and Potent Depleter of Pathogenic T

      Many failed sever

      Janet Pope Janetbirdope

      11 months ago
      #PD1 Ab looks good and safe in active RA Rosnilimab, a Selective and Potent Depleter of Pathogenic T Many failed several Rx already No safety signals compared to another PD1i Proof of benefit in biospecimens too! abst#LB19 #ACR25 @RheumNow @ACRheum #ACRBest https://t.co/TmEOCfuHZU
      Biologic choice in PsA: consider factoring in obesity ⚖️

      Abstract 2691: In a longitudinal cohort study, obesity ass

      Akhil Sood MD, MS AkhilSoodMD

      11 months ago
      Biologic choice in PsA: consider factoring in obesity ⚖️ Abstract 2691: In a longitudinal cohort study, obesity associated with ↓ odds of achieving minimal disease activity (MDA) among pts on TNFi, but not with other DMARDs @RheumNow #ACR25 https://t.co/p4KaH6HKYj
      #2661 In >5000 veterans with RA-ILD, 8 distinct FVC trajectories were identified. >1/2showed a progressive decline

      Mrinalini Dey DrMiniDey

      11 months ago
      #2661 In >5000 veterans with RA-ILD, 8 distinct FVC trajectories were identified. >1/2showed a progressive decline (≥0.7%/yr). These progressive patterns predicted higher mortality & respiratory hospitalisations, underscoring major disease heterogeneity. @RheumNow #ACR25
      TAC+MMF + GC vs TAC +GC in lupus nephritis (target trial emulation):
      🔹Higher total renal response w/ TAC + MMF + GC a

      Akhil Sood MD, MS AkhilSoodMD

      11 months ago
      TAC+MMF + GC vs TAC +GC in lupus nephritis (target trial emulation): 🔹Higher total renal response w/ TAC + MMF + GC at 12 mo (59.7% vs 33.3%) consistent in ITT & per-protocol 🔹similar adverse events reported (14.6% vs 16.4%) @RheumNow #ACR25 https://t.co/Yuql3O9C8X
      Abstract 2690: Food as a Medicine
      Mediterranean vs low-calorie DASH vs control diet in PsA (multicenter RCT):
      🔹 All

      Akhil Sood MD, MS AkhilSoodMD

      11 months ago
      Abstract 2690: Food as a Medicine Mediterranean vs low-calorie DASH vs control diet in PsA (multicenter RCT): 🔹 All 3 groups showed significant weight loss & DAPSA by wk 24 🔹 Weight loss not diet type may be the driver of clinical improvement @RheumNow #ACR25 https://t.co/rBS3HR1HXl
      #2702 @ClevelandClinic Vascular ultrasound (VUS) for suspected GCA showed excellent specificity (100%) but low sensitivi

      Mrinalini Dey DrMiniDey

      11 months ago
      #2702 @ClevelandClinic Vascular ultrasound (VUS) for suspected GCA showed excellent specificity (100%) but low sensitivity (21%) compared with 6m confirmed diagnosis. Fair agreement with TAB (κ=0.64). Findings highlight need for standardised VUS protocols in US. @RheumNow #ACR25 https://t.co/LRFpFBnWWz
      Older Adults Underrepresented in RCTs

      Drs. Jiha Lee and Sebastian Sattui discuss abstract 1072, "Inclusion of Older Ad

      Dr. John Cush RheumNow

      11 months ago
      Older Adults Underrepresented in RCTs Drs. Jiha Lee and Sebastian Sattui discuss abstract 1072, "Inclusion of Older Adults in Pharmacologic Randomized Controlled Clinical Trials of Autoimmune Rheumatic Diseases: A Systematic Review," presented at #ACR25 https://t.co/uzSPH5RbjM https://t.co/94Vw6qUOIL
      They say the easiest bit about GCA, like PMR, is the first week after you start steroids. Those fond memories belie the challenge of ongoing treatment in GCA. In a steroid-only world, there is only misery. Steroid-sparing therapies have changed this completely.
      Sooner May Still Be Too Late: Kidney Biopsies in SLE

      #ACR25 kicked off with Plenary Session by Michelle Petri (Abstrac

      Dr. John Cush RheumNow

      11 months ago
      Sooner May Still Be Too Late: Kidney Biopsies in SLE #ACR25 kicked off with Plenary Session by Michelle Petri (Abstract 0772: Redefining When to Biopsy the Kidney in Patients with SLE. As part of a collaboration with the Accelerating Medicines Partnership, Petri and colleagues https://t.co/bU09vpcDew
      In a 5-year EHR-based cohort, PsO patients initiating IL-17i had significantly lower incidence of PsA/IA vs IL-23i, IL-1

      Antoni Chan MD (Prof) synovialjoints

      11 months ago
      In a 5-year EHR-based cohort, PsO patients initiating IL-17i had significantly lower incidence of PsA/IA vs IL-23i, IL-12/23i, or TNFi. IL-17i reduced time with PsA/IA by 45% vs IL-23i, 61% vs IL-12/23i, and 74% vs TNFi. Further research need investigate if IL-17i may delay https://t.co/0PTbXZpLbu
      #ACR25 Abstr#2695 Inguinal lymph node biopsies pre- and post-OBI, RTX, BLIN & CD19 CAR-T showed complete tissue depl

      Md Yuzaiful Md Yusof Yuz6Yusof

      11 months ago
      #ACR25 Abstr#2695 Inguinal lymph node biopsies pre- and post-OBI, RTX, BLIN & CD19 CAR-T showed complete tissue depletion with CAR-T. B-cells reduced but often incomplete with protein-based depleters; OBI being the best. Still don’t agree with “immune reset” @RheumNow #ACRBest https://t.co/Sq7m9sXlLP
      #2660 In >8000 women, serum urate rose sharply during the menopausal transition, then plateaued after menopause.
      Hype

      Mrinalini Dey DrMiniDey

      11 months ago
      #2660 In >8000 women, serum urate rose sharply during the menopausal transition, then plateaued after menopause. Hyperuricemia reached 4-5% post-menopause, up to 18% in obesity or low eGFR. Healthy body weight & kidney function pre-menopause may decrease HU later @RheumNow #ACR25 https://t.co/v6ai3lgAd2
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