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      #ACR25 Abstr#2697 H2H RCT of Tacrolimus + GC vs MMF + GC in #lupus Nephritis in Asia for Induction-Maintenance showed si

      Md Yuzaiful Md Yusof Yuz6Yusof

      6 days 16 hours ago
      #ACR25 Abstr#2697 H2H RCT of Tacrolimus + GC vs MMF + GC in #lupus Nephritis in Asia for Induction-Maintenance showed similar efficacy. Different side effects: AKI more in TAC, low WCC & infections in MMF. Informative for services with no access to biologics/Voclosporin @RheumNow https://t.co/V4uWhuqjjW
      #2658 In >870k adults with T2DM or obesity, GLP-1 receptor agonists showed no increase in autoimmune or inflammatory

      Mrinalini Dey DrMiniDey

      6 days 16 hours ago
      #2658 In >870k adults with T2DM or obesity, GLP-1 receptor agonists showed no increase in autoimmune or inflammatory disease risk, and were instead linked to lower mortality, heart failure, stroke and dementia. Excellent real-world safety signals. @RheumNow #ACR25
      Abstract 2695: Deep dive into B-cell depletion (BCD)
      Lymph node biopsy pre/post tx:
      🔹 CAR T: complete BCD + disrupted

      Akhil Sood MD, MS AkhilSoodMD

      6 days 16 hours ago
      Abstract 2695: Deep dive into B-cell depletion (BCD) Lymph node biopsy pre/post tx: 🔹 CAR T: complete BCD + disrupted follicular architecture 🔹 RTX, OBI, BLIN: reduced BCD + preserved follicular architecture ✅ Complete LN depletion → drug-free remission @RheumNow #ACR25
      Inflammation skews lipid levels in RA: the “lipid paradox”

      Using data from CERTAIN and VARA, inflammation (hsCRP)-

      Jiha Lee JihaRheum

      6 days 16 hours ago
      Inflammation skews lipid levels in RA: the “lipid paradox” Using data from CERTAIN and VARA, inflammation (hsCRP)-adjusted TC & LDL better predicted ASCVD events than standard lipids. Are we missing RA pts who need statins? @RheumNow #ACR25 A#2681
      #2681 Tackling the “lipid paradox” in RA: inflammation-adjusted TC & LDL (using hsCRP correction) improved ASCVD

      Mrinalini Dey DrMiniDey

      6 days 16 hours ago
      #2681 Tackling the “lipid paradox” in RA: inflammation-adjusted TC & LDL (using hsCRP correction) improved ASCVD risk prediction and flagged more high-risk patients than standard lipids. A smarter way to guide statin use in RA. @RheumNow #ACR25
      Abst 2694:
      Post-hoc analysis of Phase 2 PAISLEY SLE trial examined impact of deucravacitinib on renal dysfunction
      🔹 P

      Akhil Sood MD, MS AkhilSoodMD

      6 days 16 hours ago
      Abst 2694: Post-hoc analysis of Phase 2 PAISLEY SLE trial examined impact of deucravacitinib on renal dysfunction 🔹 Plasma proteins a/w ↑ BILAG renal score and ↓ UPCR --> reduced by WK 32 🔹 Biomarkers inversely related to eGFR were reduced with deucra vs PBO @RheumNow #ACR25 https://t.co/6CvmQ9lCfS
      In the epidemiology session on the final day of #ACR25, a large cohort study (>430k pts) showed that GLP-1 receptor a

      Mrinalini Dey DrMiniDey

      6 days 16 hours ago
      In the epidemiology session on the final day of #ACR25, a large cohort study (>430k pts) showed that GLP-1 receptor agonists were linked to lower incidence of RA, gout & OA vs DPP-4 inhibitors. Adds to the growing case for GLP-1 benefits beyond glucose control. @RheumNow #2657
      Lots of interest in MRI for GCA diagnosis... but what about monitoring?

      Case series of 14 pts: MRI identified relapse p

      Mike Putman EBRheum

      6 days 16 hours ago
      Lots of interest in MRI for GCA diagnosis... but what about monitoring? Case series of 14 pts: MRI identified relapse prior to symptoms or inflammatory markers in 2 cases, including those on TCZ, which hides them More available in US context, noninvasive, & more structures https://t.co/pnrI9SEpll
      Deucravacitinib (TYK2) in PsA from POETYK trials

      Improved ACR20 at wk16 (NNT ~5), less benefit for ACR70 (NNT ~20)

      Ste

      Mike Putman EBRheum

      6 days 16 hours ago
      Deucravacitinib (TYK2) in PsA from POETYK trials Improved ACR20 at wk16 (NNT ~5), less benefit for ACR70 (NNT ~20) Steady improvements during open label extension (all pts received drug) Would expect approval for PsA soon... where will this fit in your approach? @RheumNow https://t.co/325h2hf0AE
      In early axSpA vs non-axSpA CBP, 2 year spinal x-ray progression was minimal in both groups. But on MRI, fat lesions inc

      Antoni Chan MD (Prof) synovialjoints

      6 days 16 hours ago
      In early axSpA vs non-axSpA CBP, 2 year spinal x-ray progression was minimal in both groups. But on MRI, fat lesions increased significantly in axSpA (0.16 units/yr vs –0.02), with 15% having ≥3 lesions at 2 year vs 1% in non-axSpA. Fat lesions may signal early structural https://t.co/zvgU1Gt0po
      #ACR25 Clinical Preview by Prof Coates for use now:

      GLP-1 agonist & Diet

      Abstr#813 GIP/GLP-1 improved MSK pain

      A

      Md Yuzaiful Md Yusof Yuz6Yusof

      6 days 16 hours ago
      #ACR25 Clinical Preview by Prof Coates for use now: GLP-1 agonist & Diet Abstr#813 GIP/GLP-1 improved MSK pain Abstr#849 GLP-1 reduced risk of #MACE in PsA Abstr#2690 RCT = the degree of weight loss regardless specific dietary strategy determined benefit in PsA @RheumNow https://t.co/4jB0fFHosC
      Observational study from VCRC AAV patinet, >70% had pulm involvement at some point

      As expected, nodules favor GPA (6

      Mike Putman EBRheum

      6 days 16 hours ago
      Observational study from VCRC AAV patinet, >70% had pulm involvement at some point As expected, nodules favor GPA (63% vs 12% MPA) & DAH favors MPA (61% vs 31%) More ILD in MPA (11% vs 1%) & more endobronchial in GPA (12% vs 2%) Helpful pearls! @RheumNow #ACR25 Abstr#0721 https://t.co/Iu5MdiTABR
      #ACR25 Clinical Preview by Prof Coates to be applied tomorrow!

      GC #steroid burden & Mx

      Abstr#738 Survey of #GCA p

      Md Yuzaiful Md Yusof Yuz6Yusof

      6 days 16 hours ago
      #ACR25 Clinical Preview by Prof Coates to be applied tomorrow! GC #steroid burden & Mx Abstr#738 Survey of #GCA patients in US & EU: 3/4 were still on GC; mean 5.3mg/d Abstr#1526 International consensus of GC taper in #SLE is available & can be applied in clinic @RheumNow https://t.co/paw7NGjs4p
      What exercise best for steroid-induced osteoporosis? Does it have to be weight bearing?

      Turns out anything helps - get

      David Liew drdavidliew

      6 days 16 hours ago
      What exercise best for steroid-induced osteoporosis? Does it have to be weight bearing? Turns out anything helps - get out there and don’t let perfect be the enemy of good! Laura Coates in the #ACR25 meeting review @RheumNow https://t.co/VGH2rz3dzb
      Does diet matter in PsA?

      Randomized study comparing advice, DASH low calorie, Mediterranean diet

      Seems that weight los

      David Liew drdavidliew

      6 days 16 hours ago
      Does diet matter in PsA? Randomized study comparing advice, DASH low calorie, Mediterranean diet Seems that weight loss corresponds better with benefit than diet. BMI reduction remains focus in PsA Laura Coates #ACR25 meeting review @RheumNow https://t.co/CqR25sJdDc
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