Anti-Rheumatic Rx

      RT @synovialjoints: Herpes Zoster vaccination in RA patients treated with Upadacitinib and MTX showed a satisfactory res

      Dr. Antoni Chan synovialjoints

      2 years 3 months ago
      Herpes Zoster vaccination in RA patients treated with Upadacitinib and MTX showed a satisfactory response, slight reduction in response compared to general population in both antibody and cell mediated responses Winthrop K, Abst#OP0225 #EULAR2023 @RheumNow https://t.co/wxwbOYsn5K
      RT @Janetbirdope: To treat or not? Clinically suspect arthralgia does affect QoL including function. Both premises of tr

      Janet Pope Janetbirdope

      2 years 3 months ago
      To treat or not? Clinically suspect arthralgia does affect QoL including function. Both premises of treating with a DMARD are valid. OverRx v missing the very early window of opportunity @RheumNow #EULAR2023 @eular_org https://t.co/86CVZ2IjEf
      RT @drdavidliew: For our rheum patients who have had cancer previously - the default can’t be to not have DMARDs.

      @eu

      David Liew drdavidliew

      2 years 3 months ago
      For our rheum patients who have had cancer previously - the default can’t be to not have DMARDs. @eular_org points to consider SLR: no clear risk, across b/tsDMARDs For too long these patients were unnecessarily asked to ride it out. No more please POS1069 #EULAR2023 @RheumNow https://t.co/7m4Yh0h7rd
      RT @Janetbirdope: Should immunosuppression be used to improve #PAH in #SSc added to PAH Rx (85%) Morbidity or mortality

      Janet Pope Janetbirdope

      2 years 3 months ago
      Should immunosuppression be used to improve #PAH in #SSc added to PAH Rx (85%) Morbidity or mortality outcomes >700 pts - half had a DMARD after dx RheumNow #EULAR2023 OP0238 Targeted Rx improved esp RTX\TCZ findings V interesting results #GameChanger May change my Rx practice!
      RT @AurelieRheumo: Retro French database study shows reassuring data.

      Overall mortality after IRAEs =similar between p

      Aurelie Najm AurelieRheumo

      2 years 3 months ago
      Retro French database study shows reassuring data. Overall mortality after IRAEs =similar between pts receiving b/tsDMARDs vs. those who don't 70000+ pts treated w/ ICI, 7800+ IRAEs (most frequent colitis) & 330 treated w/ b/tsDMARDs, 10% Rheum IRAE OP0270 @RheumNow #EULAR23 https://t.co/OFNaIU4kzt
      RT @drdavidliew: Malignancy in real world datasets:
      do we see differences between DMARDs - particularly JAKi, with ORAL

      David Liew drdavidliew

      2 years 3 months ago
      Malignancy in real world datasets: do we see differences between DMARDs - particularly JAKi, with ORAL Surveillance in mind? RABBIT German data (limited risk window): Point estimates slightly up vs TNFi, esp in high CV risk pts but magnitude not big OP0218 #EULAR2023 @RheumNow https://t.co/Ou7TgWvf3b
      RT @drdavidliew: Men trying to conceive were prev told to avoid MTX. Another myth busted

      Why? Spermatozoa lack the FPGS

      David Liew drdavidliew

      2 years 3 months ago
      Men trying to conceive were prev told to avoid MTX. Another myth busted Why? Spermatozoa lack the FPGS enzyme responsible for MTX-PG metabolism, the tiny amount of MTX-PG in sperm isn’t active. No quality issues! OP0224 #EULAR2023 @RheumNow (& @ARD_BMJ https://t.co/SDdoNP12oR)
      acr_session2.jpeg
      EULAR 2023 – Day 2 Report
      2 years 3 months ago
      Day 2 at the international EULAR Congress meeting is always bigger and busier. There were sessions on JIA therapies, crystal arthritis, novel drugs for SLE and Sjogren's, early RA and preclinical RA interventions, IgG4 disease, osteoporosis and the growth and application of artificial intelligence in medicine and rheumatology.
      RT @bella_mehta: Obesity in #AOSD – predicted the development of a chronic disease course and biologic DMARD failure,

      Bella Mehta bella_mehta

      2 years 3 months ago
      Obesity in #AOSD – predicted the development of a chronic disease course and biologic DMARD failure, 139 pts with AOSD- 19% Obese (BMI>30) observational study. abst#AB1503 #EULAR2023 @rheumnow
      RT @AurelieRheumo: ANSWER cohort
      Retrospective study 6600+ bio/tsDMARDs ttmt courses, 20 yrs
      ✔️IL-6Ri is the lowest

      Aurelie Najm AurelieRheumo

      2 years 3 months ago
      ANSWER cohort Retrospective study 6600+ bio/tsDMARDs ttmt courses, 20 yrs ✔️IL-6Ri is the lowest discontinued for lack of efficacy ✔️CTLA4-Ig is the lowest discontinued due to AEs ✔️Concomitant GC ⬆️30% drug discontinuation due to AEs @Rheumnow #EULAR23 POS0051 https://t.co/8e6U5KHmX4
      Treatment of IIM, MTX or AZA or IVIG are 1st line (with steroids). #EULAR2023 https://t.co/TDKWxgrST0

      Dr. John Cush RheumNow

      2 years 3 months ago
      Treatment of IIM, MTX or AZA or IVIG are 1st line (with steroids). #EULAR2023 https://t.co/TDKWxgrST0
      RT @AurelieRheumo: CareRA trial:
      3 months addition of LEF vs. ETA in pts resistant to COBRA-Slim regimen (MTX 15 mg/w

      Aurelie Najm AurelieRheumo

      2 years 3 months ago
      CareRA trial: 3 months addition of LEF vs. ETA in pts resistant to COBRA-Slim regimen (MTX 15 mg/w + step-down prednisone): After 2 years, no difference in dis control but those who received ETA early were treated more frequently w/ csDMARD monotherapy #EULAR23 @RheumNow OP0129 https://t.co/YwSoZWi375
      RT @drdavidliew: “You don’t need MTX with TCZ for RA”

      Err, well:
      - just like TNFi, you def can get ADAb to TCZ
      -

      David Liew drdavidliew

      2 years 3 months ago
      “You don’t need MTX with TCZ for RA” Err, well: - just like TNFi, you def can get ADAb to TCZ - they definitely lead to lower response rates - MTX co-admin reduces ADAb Seems like a good idea to me, but your call 🤷‍♂️ Bitoun, Mariette et al POS0630 #EULAR2023 @RheumNow https://t.co/2jOAqA6YZ3
      RT @synovialjoints: No relationship between MTX-PG levels in terms of efficacy by SDAI remission but higher MTX-PG level

      Dr. Antoni Chan synovialjoints

      2 years 3 months ago
      No relationship between MTX-PG levels in terms of efficacy by SDAI remission but higher MTX-PG levels related to adverse events by Tamai H, Abstr #OP0128 #EULAR2023 @RheumNow https://t.co/TiO5eeYlnS
      RT @drdavidliew: How much MTX do we need with adalimumab in RA? Can blood concentrations help?

      MTX RBC polygluts:
      - don

      David Liew drdavidliew

      2 years 3 months ago
      How much MTX do we need with adalimumab in RA? Can blood concentrations help? MTX RBC polygluts: - don’t seem to match to efficacy - do seem match to safety, a bit (no ADAb data here) *One day* we’ll get better at what MTX dose is needed with TNFi #EULAR2023 OP0128 @RheumNow https://t.co/OGM3hxr4fG
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