Autoinflammatory
ARD & RMD Open ARD_BMJ
2 years 4 months ago
EULAR/PRES recos for sJIA & AOSD
🔹sJIA = AOSD l
👉 Unique name: Still’s disease
🔹Start IL1i or IL6i as soon as diagnosis made
🔹MAS ⚠️
🔹Emerging issue: lung disease
👉Screening (HRCT if suspicion)
#EULAR2023
Pr B Fautrel & F deBenedetti
Key slides 👇🏼
NZ https://t.co/x1Snf8WI99
Dr. John Cush RheumNow
2 years 4 months ago
AOSD: Young vs. Elderly Onset AOSDis an autoinflammatory condition characterized by fevers, arthritis, and rash. It is considered an orphan disease because of its low prevalence - it is reported anywhere between 16 to 40 per ten million. https://t.co/bB2mpul3j7 https://t.co/ic6mY04ddF
Dr. John Cush RheumNow
2 years 4 months ago
AOSD: Young vs. Elderly Onset
AOSDis an autoinflammatory condition characterized by fevers, arthritis, and rash. It is considered an orphan disease because of its low prevalence - it is reported anywhere between 16 to 40 per ten million.
https://t.co/PPI1fvwLAf https://t.co/qMXMsbpwl3
David Liew drdavidliew
2 years 4 months ago
@eular_org recommendations session #EULAR2023 - and the first recommendation is one I’m so glad is up front:
Adult Onset Still’s Disease (AOSD) and Systemic JIA (sJIA) are the same disease.
If anything, it’s the really young sJIA (<18 months old) which is different @RheumNow https://t.co/OCDeeNtNoR
David Liew drdavidliew
2 years 4 months ago
@eular_org recommendation for AOSD/sJIA:
An IL-1 or IL-6 inhibitor should be initiated as early as possible when the diagnosis is established
#EULAR2023 @RheumNow https://t.co/xNUdpGDxb9
Bella Mehta bella_mehta
2 years 4 months ago
Microvascular visualization in Behcet's disease by ultrasound. Maybe really useful in cases which are difficult to diagnose and may not need biopsies in some pts.
#EULAR2023 @RheumNow https://t.co/PbC3tCe7v6
Md Yuzaiful Md Yusof Yuz6Yusof
2 years 4 months ago
#EULAR2023 Clinical Highlights. Vasculitis: OP0061 - new US imaging showing vessel inflammation differentiating patients with Behcet’s vs No-BD. OP0304: cohort study showed Benralizumab (IL5 RA) given for eosinophilic asthma also improved BVAS. RCT for EGPA is ongoing @RheumNow https://t.co/7uohfjGk49
Dr. John Cush RheumNow
2 years 4 months ago
Tune it at 1pm EST for RheumNow's daily #EULAR23 recaps. You can find us live on Twitter, YouTube and LinkedIn. https://t.co/t531csjXo8
Bella Mehta bella_mehta
2 years 4 months ago
Long term data on Canakinumab - IL-1B antibody in #AOSD @EULAR2023 25 pts with persistent disease activity, f/u 12 mths, remission in all but 2 pts. Improved parameters as below :-
@rheumnow abst#OP0257 https://t.co/7jKTp87FlX
Bella Mehta bella_mehta
2 years 4 months ago
Obesity in #AOSD – predicted the development of a chronic disease course and biologic DMARD failure, 139 pts with AOSD- 19% Obese (BMI>30) observational study. abst#AB1503 #EULAR2023 @rheumnow
Bella Mehta bella_mehta
2 years 4 months ago
Pearls in AOSD – from #EULAR2023 Italian study of 64 patients – AOSD/sJIA pts who achieved drug-free remission more often had white blood cells count >15.000/uL at baseline, however those who were treated with cyclosporine likely failed drug free remission. Abst#AB1484 @rheumnow
Adult onset still's disease (AOSD) is an autoinflammatory condition characterized by fevers, arthritis, and rash. It is considered an orphan disease because of its low prevalence - it is reported anywhere between 16 to 40 per ten million. Traditionally, a bimodal distribution by age has been reported with peaks at the ages of 15 to 25 and between 36 to 46.
Bella Mehta bella_mehta
2 years 4 months ago
An interesting biomarker in #sJIA- helps differentiate it from other diseases, including infections and other inflammatory diseases! - kids with fever! serum calprotectin (MRP8/14) particle enhanced immuno-turbidimeteic assay (sCAL Turbi). 650 pts @rheumnow
#EULAR2023 abst#OP0034
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