A highlight at #EULAR2023 AI in predicting RA from MRI scans of hands and feet in patients with early onset arthritis or clinically suspect arthralgia. From 1,974 people, 651 went on to develop RA. The accuracies were close to expert level prediction, Li Y, Abst#OP0002 @RheumNow https://t.co/MP8yn18PWI

Beydon et al., french registry study 255000+ RA patients 2010-2020 Increase ⬆️ overall malignancy by 20% vs. general pop ⬆️lung 40%, ENT 40%, cervix 80%, prostate 8%, melanoma 37% Pancreatic cancer 10% less frequent in ♂ Breast 9% & Uterine body 23% less frequent in ♀

So can computers beat humans in predicting RA from pre-RA arthralgia MRIs? No, for now… but unsupervised they pick up the same culpable features we look for: bone marrow edema & tenosynovitis. Sometimes it’s nice when the machines tell us we’re right #EULAR2023 OP0002 @RheumNow https://t.co/71Zo2JyC8d

I swear it is muscle, Doctor! GLORIA trial substudy Pred 5 mg/day 2 years in RA pts >65yo: Weight gain 1kg vs. PBO, no increase or redistribution of fat mass but augmentation in lean mass 💪 Probably explained by better disease control (although NS in study, small sample size)

EULAR PtoC management of targeted therapies in pts w/ IA & Hx cancer 1) If remission, initiate targeted therapy w/out delay 2) Prefer anti-cytokine bDMARDs if Hx solid cancer 3) B cell depleting therapy if Hx lymphoma 4) Use JAK inhibitors and abatacept with caution 🛑 https://t.co/cKhQVZwGh1

Prediction of RA early arthritis & clinically suspect arthralgia pts w/ AI analysis of MRIs scans: ✔️Feasible ✔️Accurate AUC 0.683 EA group AUC 0.727 CSA group ✔️Peformance = human experts ✚ Could identify new imaging biomarkers https://t.co/sVXw9A8NqZ OP0002 #EULAR23 @Rheumnow https://t.co/oq5RJApm9U

• EULAR Abstract Archive

Provan et al. large scandinavian registry study: 🫁ILD risk in RA & PsA initiating b/tsDMARDs HR ILD RA=10 HR ILD PsA=5 No increase risk w/ MTX and b/tsDMARDs but RA HR ILD 1.7 RTX vs. ETA: confounding by indication? https://t.co/CF1ysNkQxU OP0006 #EULAR23 @Rheumnow https://t.co/DgDE1uFeUs

• EULAR Abstract Archive

Autoimmune disease diagnoses slowly on the rise, despite reduced smoking - but that’s now 10% of the population, & many patients have more than one. Most are lifelong. Surely this needs more investment?? CPRD data from the UK #EULAR2023 OP0007 @RheumNow https://t.co/7NGF5YaE9z https://t.co/m6SaibqmEq

• https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00457-9

Scandinavian RA registry study shows reassuring data on CV risk in RA🫀 Acute Coronary Syndrom incidence rates are similar in RA pts achieving remission & general pop & is similar whether RA pts reach remission using MTX or TNFi. https://t.co/wBDZtaTVba OP0038 #EULAR23 @Rheumnow https://t.co/JLdbYF49xF

• EULAR Abstract Archive

Data from combined big Scandinavian population registries looking at both RA and PsA, ILD development, & MTX exposure Here’s the ILD risk for methotrexate. Can we stop this MTX misinformation? No more besmirching a really useful drug for our patients #EULAR2023 OP0006 @RheumNow https://t.co/7swqAYchDC