Rheumatoid Arthritis
1 year 5 months ago
Weather impacts outcomes in RA: myth or reality? ⛈🌦
Larger study to date 14200 weather-matched PROs
Mean PtP PtF PtGA scores higher in winter
Few meteorological measures significantly correlated w/ PROs, but correlations are weak
@RheumNow #EULAR23 POS0325 https://t.co/7AJmbLQrPW
1 year 5 months ago
REMOTRA; REMote moniToring in pReclinical Arthritis
43pts CSA 6 Mo follow up
Pts acceptance and usage decrease during time (like many other studies using apps)
Composite score of PROs asso w/ risk of RA (...but VPP 12%)
Digital follow up of Pre-RA is not ready for clinic yet. https://t.co/o31dVEa5xt
1 year 5 months ago
Amazing the chatter in the room for this one. The idea that a new JAKi might genuinely outperform existing JAKi in hard-to-treat RA, without safety cost, is particularly enticing.
We all want to see the paper & healthy skepticism of ph2, but watch this space #EULAR2023 @RheumNow https://t.co/jEyk8zqZN8
1 year 5 months ago
A mono therapy study RCT of TLL-018 vs #Tofa in RA subanalyses of previous JAKi exposure have not been done. Pts could have failed #Tofacitinib & enrolled so data could be divided to determine how this group responded. Safety looked good in both Rx LB0001 @RheumNow #EULAR2023 https://t.co/4kBHxWmk0q
1 year 5 months ago
What about a new oral drug in active #rheumatoid #arthritis vs #JAKi #Tofacitinib? TLL-018 a potent JAK1/TYK2 inhibitor was compared with #Tofa and dose ranging of 10, 20, 30 mg of TLL-018 and many Pts w past TNFi and w JAKi. High dose won #EULAR2023 @RheumNow @eular_org LB0001 https://t.co/UXhT7LV1oD
Day 3 was a sunny warm day in Milan at the 2023 EULAR Congress meeting. Here are a few of my favorite abstracts from today.
Rheumatoid Factor Lowering Predicts Improved Outcomes in RA. Abstract…
Rheumatoid arthritis (RA) is known to be historically associated with site specific cancers, especially lung skin and lymphomas. This risk was described as likely to be supported by chronic systemic…
The use of artificial intelligence (AI) to analyse large data sets using its subset component machine learning (ML) has taken centre stage recently in the management of rheumatic conditions,…