Janet Pope Janetbirdope
1 year 5 months ago
#ClinicalPearl Rx of #scleroderma #ILD -add another drug. MMF, then Cyclo, Rituximab, ?tocilizumab; if progressive fibrosis then #Nintedanib ?Pirfenidone Small RCT of MMF v Tacrolimus - looked the same -helpful if MMF fails, future pregnancy OP0240 @RheumNow #EULAR2023 @eular_org https://t.co/XWphyEO2JJ
Aurelie Najm AurelieRheumo
1 year 5 months ago
Natural sequence of events happening in a subclinically inflamed joint, serial MRI study
When progressing to clinical RA
First osteitis then synovitis & tenosynovitis
🦴➡️✋
During resolution tenosynovitis reduces first then synovitis & osteitis
@RheumNow #EULAR23 OP0261 https://t.co/ic94htYv6T
Md Yuzaiful Md Yusof Yuz6Yusof
1 year 5 months ago
#EULAR2023 #POS1133 Consistent with clinical response in Phase 2 RCT, therapy with Updacitinib alone and ABV599-HD (Elsubrutinib + Upadacitinib) modulated IFN-I signalling pathways (IFN gene expression & proteomics). Assuring therapeutic evidence @RheumNowNews https://t.co/27mtCNg76X
Bella Mehta bella_mehta
1 year 5 months ago
Long term data on Canakinumab - IL-1B antibody in #AOSD @EULAR2023 25 pts with persistent disease activity, f/u 12 mths, remission in all but 2 pts. Improved parameters as below :-
@rheumnow abst#OP0257 https://t.co/7jKTp87FlX
Md Yuzaiful Md Yusof Yuz6Yusof
1 year 5 months ago
#EULAR2023 #OP0226 DORIS remission in #SLE is a goal but may be slight tricky to achieve. Multicentre cohort study showed attainment of LLDAS protected against subsequent Flare and Damage @RheumNow https://t.co/MIypIDW6aE
David Liew drdavidliew
1 year 5 months ago
For our rheum patients who have had cancer previously - the default can’t be to not have DMARDs.
@eular_org points to consider SLR:
no clear risk, across b/tsDMARDs
For too long these patients were unnecessarily asked to ride it out. No more please
POS1069 #EULAR2023 @RheumNow https://t.co/7m4Yh0h7rd
David Liew drdavidliew
1 year 5 months ago
We know HCQ adherence is poor in both RA and SLE
>50% in this BC 🇨🇦 cohort
All despite being such an important medicine
What’s super interesting are the trajectories of adherence - and we’d like to understand more about what motivates each group
OP0222 #EULAR2023 @RheumNow https://t.co/rbx1l9T36C
Janet Pope Janetbirdope
1 year 5 months ago
Should immunosuppression be used to improve #PAH in #SSc added to PAH Rx (85%) Morbidity or mortality outcomes >700 pts - half had a DMARD after dx RheumNow #EULAR2023 OP0238 Targeted Rx improved esp RTX\TCZ findings V interesting results #GameChanger May change my Rx practice!
Aurelie Najm AurelieRheumo
1 year 5 months ago
Retro French database study shows reassuring data.
Overall mortality after IRAEs =similar between pts receiving b/tsDMARDs vs. those who don't
70000+ pts treated w/ ICI, 7800+ IRAEs (most frequent colitis) & 330 treated w/ b/tsDMARDs, 10% Rheum IRAE
OP0270 @RheumNow #EULAR23 https://t.co/OFNaIU4kzt
Dr. Antoni Chan synovialjoints
1 year 5 months ago
Antimalarial adherence in RA and SLE showed 4 patterns of adherence over time, with 53% drop off in 1 year, with higher adherence with age, SLE and socioeconomic class, Hoque MR, Abst#0222 #EULAR2023 @RheumNow https://t.co/Bld5kWVQxE
Bella Mehta bella_mehta
1 year 5 months ago
Fatigue in SLE remains a challenge!
Online digital tool - LEAF - Lupus Expert System for Assessment of Fatigue - assement of fatigue PROMs in 1250pts - 80% reported fatigue, 93% found tool helpful @rheumnow #EULAR2023
Need more tools to assess and manage fatigue!
abst#OP0230
Md Yuzaiful Md Yusof Yuz6Yusof
1 year 5 months ago
#EULAR2023 #POS1075 Which biologics have the lowest retention rate in Elderly patients (=>65 yrs) in Rheumatoid Arthritis? Data from Italian registry showed 1/3 discontinued biologics at 2 yrs. IL6-i: lowest persistence; Abatacept: highest @RheumNow https://t.co/28n4qzR3aM
David Liew drdavidliew
1 year 5 months ago
Can’t escape ORAL Surveillance RCT talk
Lots of real world data on CV risk & JAKi here
(with all the selection, measurement bias)
First up: multinational JAK-pot study (n=>50k)
Even if you mirror the high-risk RCT cohort - not much there for MACE
OP0219 #EULAR2023 @RheumNow https://t.co/FfNspdivri
Janet Pope Janetbirdope
1 year 5 months ago
No new predictors for decline in #SSc lung function in ILD Progression of #scleroderma Lung disease is common - risks male, dcSSc, low FVC, Topo1 @RheumNow #EULAR2023, OP0236 @eular_org https://t.co/bTxTyLE8dZ
Aurelie Najm AurelieRheumo
1 year 5 months ago
An AI algorithm to predict opined related deaths
UK database >1000000 pts, 1200+ opioids related deaths
Risk factors:
Substance used disorder
Hx self harm
Alcohol abuse
Oxycodone
Liver disease
Concomitant gabapentinoids & BZD
*no pictures allowed*
@Rheumnow OP0269 #EULAR23 https://t.co/II96fnhqy3