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David Liew drdavidliew
1 year 4 months ago
Which bDMARD first in PsA?
2023 @eular_org recommendation: no preferred order. All are equal in its eyes
#EULAR2023 @RheumNow https://t.co/6HNNamAj1J
Janet Pope Janetbirdope
1 year 4 months ago
Predictive model to predict RA status via AI , to know what goes in to model or predictions may change. Ex use of DMARDs https://t.co/fkcEKfZWl8
Bella Mehta bella_mehta
1 year 4 months ago
PsA recommendations update at #EULAR2023
New overarching principles - should take account of safety
@rheumnow https://t.co/rrZ0ViFRPs
Aurelie Najm AurelieRheumo
1 year 4 months ago
We would think that targeted therapies would have reduced GC use in RA.
Well, this is not really the case.
Comaprison of GC use in 1999-2008 vs. 2009-2018
52% of patients remain on GC for>3Mo after initiation & 1/3 still continues after 2 years!
@RheumNow #EULAR23 POS0309 https://t.co/dDkUJFlmEm
David Liew drdavidliew
1 year 4 months ago
Here are the PsA drugs that have come to market in recent years
(and what a few years it’s been)
#EULAR2023 @RheumNow https://t.co/asFsHAD21y
David Liew drdavidliew
1 year 4 months ago
It might not be perfect, but it’s just great to have a dynamic poster floor back #EULAR2023. The heartbeat of the meeting!
(this was near the end on the last day - it’s been properly hectic throughout) @RheumNow https://t.co/jPGO5dylvg
Bella Mehta bella_mehta
1 year 4 months ago
PsA update at #EULAR2023 new mechanisms of actions since the 2019 guidelines @RheumNow https://t.co/zaieEHN6sW
Janet Pope Janetbirdope
1 year 4 months ago
What is the course of clinically suspect arthralgia in CCP+ vs neg? 781 pts, 136 got RA and sl more resolved symptoms. RA developed in both groups ACPA+ develop more rapidly - if resolution, still more MRI + vs neg. #EULAR2023 POS319 @RheumNow Diff patterns of progression
Janet Pope Janetbirdope
1 year 4 months ago
#Sjogrens has a positive RCT with Dazodalibep. Well tolerated in Phase 2 RCT - Congratulations -heading to phase 3 Primary outcome positive but not 2ndary but not powered for them @RheumNow #EULAR2023 @eular_org LB0003 #SSj https://t.co/Qt0KTaNjsR
Aurelie Najm AurelieRheumo
1 year 4 months ago
Weather impacts outcomes in RA: myth or reality? ⛈🌦
Larger study to date 14200 weather-matched PROs
Mean PtP PtF PtGA scores higher in winter
Few meteorological measures significantly correlated w/ PROs, but correlations are weak
@RheumNow #EULAR23 POS0325 https://t.co/7AJmbLQrPW
David Liew drdavidliew
1 year 4 months ago
Obviously lots of real world data at #EULAR2023 on JAKi safety (cardiovascular & cancer, see ORAL Surveillance).
Real problem:
many still have shorter follow-up periods. Cancer in particular takes time. It’s great to see data now, but:
*longer follow-up needed* +++
@RheumNow https://t.co/YH4fZgNQjY
Aurelie Najm AurelieRheumo
1 year 4 months ago
REMOTRA; REMote moniToring in pReclinical Arthritis
43pts CSA 6 Mo follow up
Pts acceptance and usage decrease during time (like many other studies using apps)
Composite score of PROs asso w/ risk of RA (...but VPP 12%)
Digital follow up of Pre-RA is not ready for clinic yet. https://t.co/o31dVEa5xt
Md Yuzaiful Md Yusof Yuz6Yusof
1 year 4 months ago
#EULAR2023 #LB0003 It is unheard of therapies that potentially can improve Sjogren patients with high symptoms burden. Phase 2 RCT of Dazodalibep (CD40L-i) showed ESSPRI improved vs PBO. Numerical improvement in other secondary (Fatigue). Will await results in Phase 3 @RheumNow https://t.co/0NzR83apeY
Janet Pope Janetbirdope
1 year 4 months ago
Cool way to get peg uricase tolerated in #gout. ##Rapamycin nanoparticle Rx w SEL 212 a uricase -infusion reactions 3.4% - all premeds w steroids and antihistamines- some stomatitis - seemed to lower uric acid and have good tolerability LB0002 @RheumNow #EULAR2023 @eular_org https://t.co/xWzuY3Xkyw
David Liew drdavidliew
1 year 4 months ago
Amazing the chatter in the room for this one. The idea that a new JAKi might genuinely outperform existing JAKi in hard-to-treat RA, without safety cost, is particularly enticing.
We all want to see the paper & healthy skepticism of ph2, but watch this space #EULAR2023 @RheumNow https://t.co/jEyk8zqZN8
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