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Novel Rx

      In SLEek LTE, ABBV-599 HD (BTKi+JAKi) & UPA 30mg sustained or improved disease control through 104wks: SRI-4 ≥82%,

      Mrinalini Dey DrMiniDey

      4 months 2 weeks ago
      In SLEek LTE, ABBV-599 HD (BTKi+JAKi) & UPA 30mg sustained or improved disease control through 104wks: SRI-4 ≥82%, ↓flares, near steroid-free, no new safety signals. PBO-switchers improved too. Targeted oral combos look promising. @RheumNow #EULAR2025 #OP0198 https://t.co/IHXC2iD0h6
      Secukinumab Use in Refractory Giant Cell Arteritis

      In 2023, the phase 2 TitAIN study showed that the effectiveness and

      Dr. John Cush RheumNow

      4 months 2 weeks ago
      Secukinumab Use in Refractory Giant Cell Arteritis In 2023, the phase 2 TitAIN study showed that the effectiveness and safety of secukinumab in 52 patients with giant cell arteritis (GCA) who had an inadequate response to tocilizumab. While we await the results of a larger https://t.co/pG3aN3o4GZ
      #Oninutuzumab works in
      #lupus #nephritis #LN

      no matter how you vary the
      #renal #responses
      Of various definitions of

      Janet Pope Janetbirdope

      4 months 2 weeks ago
      #Oninutuzumab works in #lupus #nephritis #LN no matter how you vary the #renal #responses Of various definitions of #Complete & #Partial #renal #responses abst#OP0006 #EULAR25 @eular_org @RheumNow Not surprised 😲 https://t.co/Zn2lXkddez
      1 shot will do!

      #symptomatic #Knee #OA given #gene #therapy #intra-#articular

      Seemed to last up to 104 weeks!

      But no

      Janet Pope Janetbirdope

      4 months 2 weeks ago
      1 shot will do! #symptomatic #Knee #OA given #gene #therapy #intra-#articular Seemed to last up to 104 weeks! But no placebo small safety study but sustained #WOMAC responses Needs large #RCT but v interesting #EULAR2025 @RheumNow @eular_org Abst# POS0492 https://t.co/hqTqBorrbA
      Secukinumab for PMR?
      -post hoc analysis of the TitAIN study (phase 2 RCT on new onset/relapsing GCA) showed:
      -Numerical

      Adela Castro AdelaCastro222

      4 months 2 weeks ago
      Secukinumab for PMR? -post hoc analysis of the TitAIN study (phase 2 RCT on new onset/relapsing GCA) showed: -Numerical reduction in patients experiencing PMR symptoms when treated with secukinumab compared to placebo. -Safety profile was similar to the overall GCA study
      In vitro, balinatunfib (TNFR1-selective inhibitor) preserved Treg expansion in CD4+ T cells co-cultured with IL-2 and me

      Antoni Chan MD (Prof) synovialjoints

      4 months 2 weeks ago
      In vitro, balinatunfib (TNFR1-selective inhibitor) preserved Treg expansion in CD4+ T cells co-cultured with IL-2 and memTNF (Treg 8.99 percent, p<0.0001), unlike adalimumab and etanercept which reduced Tregs by 27.5 to 41 percent. Confirms TNFR2 sparing with selective TNFR1 https://t.co/xaczz87Xrd
      VEGF-Grab (PB101/PB102), dual VEGF/PlGF decoy receptor, inhibited angiogenesis, RA-FLS invasion, and Th17 cell different

      Antoni Chan MD (Prof) synovialjoints

      4 months 2 weeks ago
      VEGF-Grab (PB101/PB102), dual VEGF/PlGF decoy receptor, inhibited angiogenesis, RA-FLS invasion, and Th17 cell differentiation in RA and MS models. PB102 reduced IL-17 and GM-CSF co-expressing Th17 cells, suppressed pannus and joint destruction in CIA, and outperformed IFN-β in https://t.co/qhVRYT4RbK
      #EULAR2025 Abstr#OP0002 Promising new mode of action therapy for #myositis. Phase 2 RCT of efgartigimod (FcRn-i; coformu

      Md Yuzaiful Md Yusof Yuz6Yusof

      4 months 2 weeks ago
      #EULAR2025 Abstr#OP0002 Promising new mode of action therapy for #myositis. Phase 2 RCT of efgartigimod (FcRn-i; coformulated with recombinant PH20) showed improvement in TIS & other key endpoints vs PBO at Wk24. Injection reaction common (23%). Will proceed to Phase 3 @RheumNow https://t.co/SuMolfcDkS
      Cool technology reduces dose interval of #IL17AFi
      To…every 6 to 12 months!

      #Antibody ORKA-002 has end of arms w YTE

      Janet Pope Janetbirdope

      4 months 2 weeks ago
      Cool technology reduces dose interval of #IL17AFi To…every 6 to 12 months! #Antibody ORKA-002 has end of arms w YTE substitution prolonging circulation of drug Lasts longer than #bimekizumab Easier for adherence! #EULAR2025 @RheumNow @eular_org #abstPOS0016 https://t.co/KcKaIe0WMs
      Despite the advances in the treatment of PsA with biologic (bDMARD) and targeted synthetic (tsDMARD), less than half of patients with this condition achieved remission or low disease activity. Combination DMARD treatment is often used in order to achieve remission or minimal disease activity. The standard practice is to use a conventional synthetic (csDMARD) with a bDMARD. The use of the combination of bDMARD with a tsDMARD such as a JAKi or
      ❓️How effective and safe is it to combine bDMARDs and tsDMARDS (i.e. TNFi/ IL17i + JAKi/TYKi) in #psoriatic_arthrit

      Nelly ZIADE 🍀 Nellziade

      4 months 2 weeks ago
      ❓️How effective and safe is it to combine bDMARDs and tsDMARDS (i.e. TNFi/ IL17i + JAKi/TYKi) in #psoriatic_arthritis? 🅰️ Reassuring data from a case-series study presented by Andre Lucas Ribeiro #EULAR2025 OP0090 @RheumNow #Strategy https://t.co/W8fuzSgxbJ
      Efficacy and safety of deucravacitinib up to week 52 in the POETYK PsA-2 study
      •ACR20 at W16: 54.2% (deucravacitinib)

      Antoni Chan MD (Prof) synovialjoints

      4 months 2 weeks ago
      Efficacy and safety of deucravacitinib up to week 52 in the POETYK PsA-2 study •ACR20 at W16: 54.2% (deucravacitinib) vs 39.4% (placebo), p=0.0002 •PASI75: 40.9% vs 15.4%, p<0.0001 •MDA: 25.6% vs 14.7%, p=0.0007 •FACIT-F: +2.5 vs +1.8 •SAE: 1.9% (low) TYK2 inhibition shows https://t.co/JXTZRk2itA
      In propensity-matched RA cohort (n=2,449 each) on JAK inhibitors, adding a GLP-1 agonist reduced risk of: • Acute coro

      Jiha Lee JihaRheum

      4 months 2 weeks ago
      In propensity-matched RA cohort (n=2,449 each) on JAK inhibitors, adding a GLP-1 agonist reduced risk of: • Acute coronary syndromes (RR 0.65, p=0.0009) • DVT (RR 0.69, p=0.007) Overall CV events ↓ by 33% (RR 0.67, p=0.0007) #EULAR2025 @RheumNow Abstract#OP0069 https://t.co/jWI6tvri8O
      Xeligekimab in AS:
      -IL-17A blocker
      -Phase 3 study on Chinese pts showed sustained efficacy until week 48.
      -Significant i

      Adela Castro AdelaCastro222

      4 months 2 weeks ago
      Xeligekimab in AS: -IL-17A blocker -Phase 3 study on Chinese pts showed sustained efficacy until week 48. -Significant improvement on DAI measures as well. -Fully humanized IgG4 mab may last longer in system and possible less ADAs. Abstract #OP0102 #EULAR2025 @RheumNow https://t.co/vyNHZ9ssFt
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