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Autoinflammatory

      Nurse-Led Treat-to-Target Clinics
      • EurekAlert!
      New studies shared at the 2025 annual EULAR congress in Barcelona highlight the benefits that nurse-led care can bring for both patients and healthcare systems.
      Saturday was the final day of EULAR, and included several lectures, but mostly late breaking abstracts and new EULAR guidelines - notably on Rheumatoid Arthritis and another on Interstitial Lung disease in connective tissue disorders. My favorite presentations included the following.
      To address this, a French multi-centre prospective pregnancy observational cohort was set up, to analyse disease activity, treatment, pregnancy outcomes, delivery, and neonatal health. The work – presented at the 2025 annual congress of EULAR – showcased findings from 97 women with an autoinflammatory disease.
      EULAR FMF recommendations 2025:
      still emphasis on colchicine adherence to maximal dose
      +/- bDMARDs if needed for control

      David Liew drdavidliew

      3 weeks 1 day ago
      EULAR FMF recommendations 2025: still emphasis on colchicine adherence to maximal dose +/- bDMARDs if needed for control +/- csDMARDs for residual chronic MSK involvement new: consider tapering bDMARD if remission >6mo See the treatment algorithm below⬇️ #EULAR2025 @RheumNow https://t.co/Hy6DOKzfUL
      FMF #Recommendations

      🔺️Start Colchicine in All (& continue for confirmed pts)
      🔺️Single or divided dose, d

      Nelly ZIADE 🍀 Nellziade

      3 weeks 1 day ago
      FMF #Recommendations 🔺️Start Colchicine in All (& continue for confirmed pts) 🔺️Single or divided dose, depend on adherence & tolerance 🔺️Max dose 2 mg children, 3 mg adults 🔺️if failure: add IL1i (6 RCT) (2 for IL6i) 🔺️Add c or bDMARd if MSK #EULAR2025 @RheumNow https://t.co/fPyQrLbb6S
      FMF #Recommendations

      During attack:
      🔺️No use of increasing Colchicine
      🔺️No use for corticosteroids and opioi

      Nelly ZIADE 🍀 Nellziade

      3 weeks 1 day ago
      FMF #Recommendations During attack: 🔺️No use of increasing Colchicine 🔺️No use for corticosteroids and opioid 🔺️Use NSAIDs #EULAR2025 @RheumNow https://t.co/jJjWJra7yr
      FMF #Recommendations

      #Colchicine can be fatal

      🔺️Beware of drug interactions
      🔺️Mostly statins in adults
      🔺?

      Nelly ZIADE 🍀 Nellziade

      3 weeks 1 day ago
      FMF #Recommendations #Colchicine can be fatal 🔺️Beware of drug interactions 🔺️Mostly statins in adults 🔺️Macrolides in children #EULAR2025 @RheumNow https://t.co/SYGLpAJXFu
      Procalcitonin can be used in the monitoring of infection, but is also high in Stills disease. 89 AOSD pts showed pts w h

      Dr. John Cush RheumNow

      3 weeks 2 days ago
      Procalcitonin can be used in the monitoring of infection, but is also high in Stills disease. 89 AOSD pts showed pts w high PCT had more pleuritis, MAS,^LFTs, & correlated w/ Dz activity, CRP, LDH, hi ferritin & normalized w bDMARD Rx. #EULAR2025 abstr #POS1118 https://t.co/NpRA9optd3
      "H Syndrome" review of 23 French pts. Autoinflammatory dz due to variants of SLC29A3 gene. Multisystem histiocytic lymph

      Dr. John Cush RheumNow

      3 weeks 2 days ago
      "H Syndrome" review of 23 French pts. Autoinflammatory dz due to variants of SLC29A3 gene. Multisystem histiocytic lymphoproliferative disorder of young adults- skin 2/3, sensorineural hearing loss, fever w/ endo & autoimmune dz. Best responses w IL6 inhib. #EULAR2025 Abst https://t.co/F7NGI4TkJS
      The definition of MAS. MAS is secondary HLH. Other causes of secondary HLH are infections, malignancy and iatrogenic.

      G

      Antoni Chan MD (Prof) synovialjoints

      3 weeks 3 days ago
      The definition of MAS. MAS is secondary HLH. Other causes of secondary HLH are infections, malignancy and iatrogenic. Georgin-Lavialle S @RheumNow #EULAR2025 https://t.co/CpB78JBlVJ
      Total serum IL 18 can help instead of CDC42 or NLCR4 genetic testing in #MAS
      Several monogentic mutations in primary HL

      Bella Mehta bella_mehta

      3 weeks 3 days ago
      Total serum IL 18 can help instead of CDC42 or NLCR4 genetic testing in #MAS Several monogentic mutations in primary HLH- these panels can be available.. #EULAR2025 @RheumNow
      Age of onset is really important when thinking about #MAS
      Primary HLH more frequent in pediatric population. But can c

      Bella Mehta bella_mehta

      3 weeks 3 days ago
      Age of onset is really important when thinking about #MAS Primary HLH more frequent in pediatric population. But can continue to adulthood. #EULAR2025 @RheumNow https://t.co/J7xmTiQiwr
      MAS can be triggered by infections in VEXAS syndrome. The threshold is reached leading to a hyperinflammatory state

      Ge

      Antoni Chan MD (Prof) synovialjoints

      3 weeks 3 days ago
      MAS can be triggered by infections in VEXAS syndrome. The threshold is reached leading to a hyperinflammatory state Georgin-Lavialle S @rheumnow #EULAR2025 https://t.co/NKLL75rOgP
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