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      "the further I look back, the further I can see the future"

      Dennis McGonagle quoting Winston Churchill to describe his

      Aurelie Najm AurelieRheumo

      1 week 6 days ago
      "the further I look back, the further I can see the future" Dennis McGonagle quoting Winston Churchill to describe his approach to understanding What is New in PsA at #EULAR2026 @eular_org @RheumNow https://t.co/ayInzzb9lO
      Clinicians often come across the scenario of a patient with well-controlled spondyloarthritis where the ASDAS in the low disease activity range, CRP normalised, joints clinically quiet. However, the patient returns to the clinic still reporting significant pain. Their rheumatologist adjusts the biological, waits, returns. The pain persists.
      Over 70% of patients with PsA struggle with excess weight, amplifying synovio-entheseal inflammation and blunting biologic response. The rapid uptake of GLP-1RAs in rheumatology has raised an urgent mechanistic question: are clinical gains in PsA driven purely by weight reduction, or do these agents carry intrinsic anti-inflammatory properties? EULAR 2026 offered six abstracts that together illuminate, without fully resolving, this question.
      πŸ”Can early TNFi beat step-up csDMARDs in pSpA?

      SPARTACUS RCT (n=97) says YES
      60% vs 33% remission at 24 wks

      #EULAR2

      Nelly ZIADE πŸ€ Nellziade

      1 week 6 days ago
      πŸ”Can early TNFi beat step-up csDMARDs in pSpA? SPARTACUS RCT (n=97) says YES 60% vs 33% remission at 24 wks #EULAR2026 @rheumnow #OP0107 https://t.co/1odtcRdTLQ
      πŸ’‰ IXE+TZP beat IXE alone in obese PsA?

      YES - TOGETHER-PsA RCT
      33.5% vs 20.4% ACR50 at week 36 in 271 patients

      OP069

      Nelly ZIADE πŸ€ Nellziade

      1 week 6 days ago
      πŸ’‰ IXE+TZP beat IXE alone in obese PsA? YES - TOGETHER-PsA RCT 33.5% vs 20.4% ACR50 at week 36 in 271 patients OP069 #EULAR2026 @RheumNow @DrLauraCoates @AlexisOgdie https://t.co/orvAe38alc
      πŸ₯— Does diet improve PsA?

      DIPSA RCT: Mediterranean/DASH/Standard all improved DAPSA in 92pts

      Weight loss drove outco

      Nelly ZIADE πŸ€ Nellziade

      1 week 6 days ago
      πŸ₯— Does diet improve PsA? DIPSA RCT: Mediterranean/DASH/Standard all improved DAPSA in 92pts Weight loss drove outcomes OP070 #EULAR2026 @RheumNow https://t.co/k5y7bvDbDQ
      HLA-Cw6: a marker of more severe and difficult to manage psoriatic arthritis?

      POS0484
      #EULAR2026
      @RheumNow https://t.co

      Nelly ZIADE πŸ€ Nellziade

      1 week 6 days ago
      HLA-Cw6: a marker of more severe and difficult to manage psoriatic arthritis? POS0484 #EULAR2026 @RheumNow https://t.co/MIYZxuYT4v
      Psoriatic arthritis #PsA sessions raised important topics on intercepting arthritis in psoriasis, treating obesity as a

      Antoni Chan MD (Prof) synovialjoints

      1 week 6 days ago
      Psoriatic arthritis #PsA sessions raised important topics on intercepting arthritis in psoriasis, treating obesity as a disease target, synovial biopsy to guide treatment, molecular imaging to reveal subclinical disease. More tomorrow. #Rheumatology @RheumNow #EULAR2026
      Dietary interventions are rarely taken as seriously as pharmacological therapies in rheumatology. Yet patients ask about them constantly, and an increasing number of studies suggest that nutrition may influence disease outcomes. Two randomized controlled trials presented at EULAR 2026 add to this growing literature in PsA and RA. However, before we start prescribing Mediterranean diets, the data deserve a closer look.
      Biopsy-guided treatment in PsA: match the drug to the tissue pathotype with 68% in LDA/remission vs 48% standard of care

      Antoni Chan MD (Prof) synovialjoints

      1 week 6 days ago
      Biopsy-guided treatment in PsA: match the drug to the tissue pathotype with 68% in LDA/remission vs 48% standard of care at 6 months. In myeloid CD117+ patients, mean DAPSA reduction at 6 months: IL-17i: βˆ’13.5, IL-23i: βˆ’12.8, TNFi: βˆ’7.5. Synovial biopsy with myeloid CD117+
      It's unclear whether GLP-1agonists inmpvove PsA from weight loss or other MoA

      74 PsA patients on GLP-1RA vs 74 matched

      Aurelie Najm AurelieRheumo

      1 week 6 days ago
      It's unclear whether GLP-1agonists inmpvove PsA from weight loss or other MoA 74 PsA patients on GLP-1RA vs 74 matched controls (BMI + disease activity matched) After adjusting for BMI change PROs still improve cDAPSA (-0.4/mo) DAPSA (-0.6/mo) and pain but not SJC, TJC or CRP https://t.co/dcaU2jwbKJ
      Izokibep IL-17A Affibody PsA

      343 pts RCT PBO crossover wk16
      52 wks data
      ACR50 50–57% ACR70 36–42% PASI100 64% MDA

      Aurelie Najm AurelieRheumo

      1 week 6 days ago
      Izokibep IL-17A Affibody PsA 343 pts RCT PBO crossover wk16 52 wks data ACR50 50–57% ACR70 36–42% PASI100 64% MDA 47–52% No diff between QW vs Q2W AE Injection-site reactions, URTIs most common No new safety signals Looks like any other IL17Ai to me #EULAR2026 #OP073 https://t.co/WiHT8Plitn
      Can we intercept PsA?

      Retro study 394 PSO pts 17 yrs follow-up 86 PsA

      TNFi linked to higher PsA incidence vs IL- MoA
      T

      Aurelie Najm AurelieRheumo

      1 week 6 days ago
      Can we intercept PsA? Retro study 394 PSO pts 17 yrs follow-up 86 PsA TNFi linked to higher PsA incidence vs IL- MoA TNFi 45% vs IL-17i 14% vs IL-23i 10% vs IL-12/23i 11% After adjustment IL-17i HR 0.35 IL-23i HR 0.17 Needs prospective confirmation! #OP072 #EULAR2026 https://t.co/88RaukjLjY
      At Week 52 with izokibep in #PsA PASI90: 63–69%; PASI100: 55–64%; MDA: 47–52%. The small-molecule format may enabl

      Antoni Chan MD (Prof) synovialjoints

      1 week 6 days ago
      At Week 52 with izokibep in #PsA PASI90: 63–69%; PASI100: 55–64%; MDA: 47–52%. The small-molecule format may enable deeper tissue penetration. Novel anti-IL-17 approach. Abstr#073 @RheumNow #EULAR2026 #Biologics https://t.co/IaJ1gyECZu
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