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      #EULAR2026 POS0713 Is there a hope for BTK-inhibition in #SLE despite several previous failures? A Phase IIb RCT in Chin

      Md Yuzaiful Md Yusof Yuz6Yusof

      6 days 14 hours ago
      #EULAR2026 POS0713 Is there a hope for BTK-inhibition in #SLE despite several previous failures? A Phase IIb RCT in China: primary endpoint (SRI-4) was met in Orelabrutinib vs PBO in dose-dependent manner. No new safety signal. Phase 3 RCT is underway @RheumNow https://t.co/4cJ8ezppTS
      Gecacitinib (pan-JAK inhibitor) vs placebo in radiographic #axSpA ASAS40 51.9% vs 12.9% (p<0.0001) at 16 weeks. ASAS2

      Antoni Chan MD (Prof) synovialjoints

      6 days 14 hours ago
      Gecacitinib (pan-JAK inhibitor) vs placebo in radiographic #axSpA ASAS40 51.9% vs 12.9% (p<0.0001) at 16 weeks. ASAS20 69.2% vs 21.2% (p<0.0001). Pan-JAK inhibition showed efficacy in TNFi-experienced patients. Abstr OP0240 @RheumNow #EULAR2026
      #proof of #concept in #Sjogren’s #dis

      #lanalumab Treatment reduced in #SjD
      ✅reduced B cells in #salivary #glands
      ?

      Janet Pope Janetbirdope

      6 days 14 hours ago
      #proof of #concept in #Sjogren’s #dis #lanalumab Treatment reduced in #SjD ✅reduced B cells in #salivary #glands —nearly complete depletion in serum ✅reduced B cell activation ✅improved #inflammation of #parotid & #submandibular glands @RheumNow #EULAR2026 #OP0163 #POS0284
      Updates in SLE and APS
      • 2026 EULAR Press Release
      Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) often overlap. While there have been some therapeutic advances, significant needs remain around diagnosis and monitoring, with a gap around definitions and biomarkers for refractory disease or specific subsets. EULAR – The European Alliance of Associations for Rheumatology – held its 2026 annual Congress in London, where new data showcased advances in the field. 
      Interim results from ASTER, a study on real world effectiveness of ANI in SLE: Pts receiving ANI had improvements in to

      sheila RHEUMarampa

      6 days 14 hours ago
      Interim results from ASTER, a study on real world effectiveness of ANI in SLE: Pts receiving ANI had improvements in total SLEDAI-2K scores after 1 yr ffup period MCT, MSK & hema had the highest decrease in SLEDAI-2K scores from pre-tx to 1yr ffup OP342 @RheumNow #EULAR2026 https://t.co/DArOwQtxM6
      ETA+MTX vs triple therapy after MTX failure in #RA: machine learning-emulated RACAT trial (n=3,472 VA pts) confirms ETA+

      Jiha Lee JihaRheum

      6 days 14 hours ago
      ETA+MTX vs triple therapy after MTX failure in #RA: machine learning-emulated RACAT trial (n=3,472 VA pts) confirms ETA+MTX modestly better overall. But smoking matters: benefit disappears in current smokers. Precision medicine from RWD. @RheumNow #EULAR2026 POS0255
      Baricitinib inhibits substance P and IL6 - by interfering with the pathway NGF-IL6-SP axis. This is a novel pathway to

      Bella Mehta bella_mehta

      6 days 14 hours ago
      Baricitinib inhibits substance P and IL6 - by interfering with the pathway NGF-IL6-SP axis. This is a novel pathway to pain suppression in RA #EULAR2026 #pos0217 @rheumnow https://t.co/6MsrFH3Mm0
      #EULAR2026 POS0156 “TWO’S company, THREE’S a crowd” Tri-specific CD19/CD3/CD28 (i.e. CD28 co-stimulates Tcell ac

      Md Yuzaiful Md Yusof Yuz6Yusof

      6 days 14 hours ago
      #EULAR2026 POS0156 “TWO’S company, THREE’S a crowd” Tri-specific CD19/CD3/CD28 (i.e. CD28 co-stimulates Tcell activation) TriTE via IV showed early efficacy & safety in 11 #SLE patients up to 48WKS. Longer FU needed to see if repeat dosing needed @RheumNow https://t.co/FpXzJIYwZF
      Rapcabtagene Autoleucel -YTB323 rapidly manufactured CD19 CAR T
      #POS0303 #EULAR2026 @RheumNow
      24 months follow up data

      Bella Mehta bella_mehta

      6 days 14 hours ago
      Rapcabtagene Autoleucel -YTB323 rapidly manufactured CD19 CAR T #POS0303 #EULAR2026 @RheumNow 24 months follow up data for 21 pts. Durable b cell reduction and decrease in disease activity. https://t.co/m3lYjZJJIy
      #OP0342 Interim real-world ASTER data showed anifrolumab improved overall SLEDAI-2K scores & reduced disease activit

      Mrinalini Dey DrMiniDey

      6 days 14 hours ago
      #OP0342 Interim real-world ASTER data showed anifrolumab improved overall SLEDAI-2K scores & reduced disease activity across multiple organ systems over 12 months, particularly mucocutaneous & MSK domains. Nearly 30% achieved SLEDAI-2K=0 at 1 year. #EULAR2026 @RheumNow https://t.co/IJlDnHSTh2
      Hypertension was the most robust and consistent predictor of pre term labor. Data from germany nationwide #POS1062 @Rheu

      Bella Mehta bella_mehta

      6 days 14 hours ago
      Hypertension was the most robust and consistent predictor of pre term labor. Data from germany nationwide #POS1062 @RheumNow ##EULAR2026 https://t.co/Uccf11PpAK
      #OP0336 Exploratory analyses from REGENCY👑OBI +standard tx induced ⬆️ histological remission & markedly gre

      Mrinalini Dey DrMiniDey

      6 days 14 hours ago

      #OP0336 Exploratory analyses from REGENCY👑 OBI +standard tx induced ⬆️ histological remission & markedly greater kidney tissue B-cell depletion vs PBO in lupus nephritis. Many patients without clinical CRR still achieved histologic remission. #EULAR2026 @RheumNow #EULARBest https://t.co/DoOlRO9QsC

      #OP0340 Long-term DARALUP data suggest CD38-targeting with daratumumab may be promising in refractory SLE, with rapid se

      Mrinalini Dey DrMiniDey

      6 days 14 hours ago
      #OP0340 Long-term DARALUP data suggest CD38-targeting with daratumumab may be promising in refractory SLE, with rapid serologic and clinical improvements sustained to 84 weeks in many patients. Flares occurred in 6/10 patients but responded to belimumab. #EULAR2026 @RheumNow
      Post marketing safety signals of anifrolumab from US FDA adverse event reporting system - herpes zoster significantly as

      Bella Mehta bella_mehta

      6 days 14 hours ago
      Post marketing safety signals of anifrolumab from US FDA adverse event reporting system - herpes zoster significantly associated. Others include infusion reactions and intermittent hypersensitivity @RheumNow ##EULAR2026 #POS1067
      Sarcoidosis increases the risk of MGUS and multiple myeloma. Propensity matched Data from a large global collaborative

      Bella Mehta bella_mehta

      6 days 14 hours ago
      Sarcoidosis increases the risk of MGUS and multiple myeloma. Propensity matched Data from a large global collaborative network study with 40k pts. POS0231 #EULAR2026 @RheumNow https://t.co/mygYCjigFV
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