🆕 Main findings of #Lupus trials presented at #ACR21 ⬇️ https://t.co/HENxcyLuf5

Dr. Melissa Munroe - Lupus Classification Risk Immune Index 🔹Pre-/post-classification serum 🔹Avg time➡️classification 4.7y 🔹9 immune mediators altered in pre-clinical dz 🔹Pos score = ⬆️likelihood➡️SLE; Neg = ⬇️ https://t.co/UFEkGieXum 1/2 #ACR21 Abst#1423 @RheumNow #ACRBest

• Ability of Soluble Immune Mediators and SLE-associated Autoantibody Specificiti…

ANA negative SLE! Lunch w/Dr. John P Atkinson. When I was in training @WUSTLrheum he bet that if you come across a case of ANA neg- SLE that is convincing, he will buy lunch. Great case of SLE following spont coronary artery dissection. #ThievesMarket #ACR21 Abst#TM18 @rheumnow https://t.co/TRyQaJ4kbR

Dr. Despotovic shares general principles about ICU admissions in patients w/ #rheumatic disease. 🔺#SLE, RA, systemic #vasculitis, SSc, IIMs 🔺serologic testing useful but interpret w/n clinical context @RheumNow #ACR21 https://t.co/jb3Mt31dZz

#ACR21 Thieves: SLE and SSc with worsening cytopenia and hematuria despite treatment: Maria Powell - presents overlap case with PNH, responded to eculizumab @Rheumnow https://t.co/CGvHEMA3lI

⬆HCQ blood levels significantly associated w/ ⬇ in mean SLEDAI, UPCR, SBP & platelet cts 🔷Assoc'n strongest in HCQ conc'n in range 0-1000ng/mL A possible HCQ blood level target to ⬇ 👁toxicity?🤔 @RheumNow #ACR21 abs1753 https://t.co/3jkDDakIcb

Interesting study on Pioglitazone significantly improving vascular stiffness and cardiometabolic parameters vs. PBO in #lupus by @sarfarazhasni et al. Pioglitazone: potential tx option to reduce CV risk in SLE?🧐 @RheumNow #ACR21 abs1748 https://t.co/ow3zA2hhnx

In this study: 💊No correlation bet QTc interval & whole blood HCQ level regardless of dose, CKD or abnormal TTEs in #lupus pts 💊+correlation bet QTci & HCQ levels in pts w/ QTc prolonging drugs but not >456ms Reassuring, dispels concern on HCQ use @RheumNow #ACR21 abs1743 https://t.co/kpASRAXJB1

#ACR21 Ab#L02 - #COVID19 vax in rheumatic pts: ❌No ⬆️ in disease activity scores post-vaccination ❌No serious adverse event ▶️Vax response 88% in RA, 78% in SLE, 87% other rheum diseases after 2 shots vs 100% controls ⭐️RTX and MMF ⬇️ responses @Rheumnow https://t.co/BChhmW0jpy https://t.co/2q8IKRoYqW

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#ACR21 #Abstr1491 What’s new in skin #lupus aetiology? Paired skin & blood using scRNA-seq: 💠Nonlesional skin in CLE/SLE is IFN-I-riched 💠Lupus-enriched CD16+ DCs undergo robust IFN education in the skin & gained pro-inflammatory phenotypes @RheumNow https://t.co/70zrC4T7SB https://t.co/75HjvGmNTa

• Single-cell Analysis of Paired Skin and Blood Samples from Patients with SLE an…

In this study by Prof MAringer et al, majority of #lupus pts enrolled in TULIP 1/2 met the the EULAR/ACR 2019 #SLE criteria 🦋Of few pts not meeting new criteria, most were ANA- w/detectable anti-dsDNA/Smith Ab Better outcomes for criteria+ in TULIP1/2? @RheumNow #ACR21 abs1733 https://t.co/XpfMZQLGUv

Minority (African American and Hispanic) #SLE patients have worse #COVID19 outcomes – double whammy! Data from the @rheum_covid #ACR21 @rheumnow #abst1933

#SLE patients with limited health literacy affects vulnerable black patients in multiple domains – worse disease activity/damage, physician/patient communication, worse patient centered care, and patient activation @mithurheum #ACR21 @rheumnow #ACRBest abst#L08

#ACR21 #Abstr1492 Could gut microbiome contribute to Anti-Ro+/autoimmunity in #lupus? Analyses of 125 stool samples from mother of children with neonatal lupus and/or heart block revealed its potential role in genetic-environment interaction @RheumNow https://t.co/FnJtZJSCRj https://t.co/ttRdP9NIrG

• A Permissive Factor of Anti-Ro+ Mothers of Neonatal Lupus Children Is Linked to…