#ACR21 Year in Review. Caielli et al. showed in some patients with #lupus, red blood cells retained their mitochondria (Mito+ RBCs) and their frequency correlated with disease activity and blood⬆️IFN @RheumNow https://t.co/ZixgAbOWJ0 https://t.co/hkTWE4m7Ph

• DEFINE_ME

#Abstr0076 #ACR21 Can we predict #thrombosis in #lupus patients? Predictors of serology transition at 5yrs: ✅LAC+ to LAC-:Afro-American,HCQ and normal C3 ⛔️LAC+ to 🩸Clot:Obesity, low C3 and not on HCQ Data need in those with Triple Positivity @RheumNow https://t.co/byeL5NjVUS https://t.co/CchtZir2GN

• Predicting the Transitions Between Lupus Anticoagulant Status and Thrombosis in…

Either we need to review the Yearly PAP cervical screening in SLE women or work hard to improve patient awareness. Suspect the latter as time between tests was over 4 years late 😱 and 2.7% developed cancer #ACR21 #Abstr0133 @RheumNow https://t.co/wm01MfoFjf https://t.co/blD8WafZsE

• Cervical Cancer Screening Rate in Women with Systemic Lupus Erythematosus - ACR…

#ACR21 #Abstr0454 Mortality rate in #lupus nephritis ⬇️by 26% from 1999-2019👏. BUT, racial and residence disparities were concerning; worse in Black, Hispanic, Asian, AI/AN vs White and in large central and medium metro. Residential matters! @RheumNow https://t.co/33vN39acuL https://t.co/XMwN2hXJn7

• Lupus Nephritis Mortality in the United States, 1999-2019: Profound Disparities…

#ACR21 #Abstr0768 We need to improve disparity among all levels of income. Support to the lowest income group seemed to improve but children with #lupus who were in the 2nd level income quartile had the longest length of stay in the hospital #RheumNow https://t.co/7HSveerUhs https://t.co/cSQBELopH5

• Poverty and Length of Stay in Children Hospitalized with Pediatric Systemic Lup…

Small but important study of LN Class III, IV, and/or V with 6/18 pts considered complete responders by UProt (<500mg/g) continued to⬇️in renal fxn over 5 yrs. Bottom line: even dramatic ⬇️UProt does not tell the whole story. https://t.co/51x4DlXkJC #ACR21 Abst#1284 @RheumNow

• One Third of Lupus Nephritis Patients Classified as Complete Responders Continu…

Infxn risk of 1st year on rituximab for mod to severe SLE vs standard-of-care 🔹Most common SoC Rx: MMF, Aza, and/or cyclophosphamide 🔹🚫significant diff 🔹RTX pts = ⬆️dz duration, ⬆️# of prior meds, ⬇️maintenance steroid dose https://t.co/AYQFXqlubl #ACR21 Abst1288 @RheumNow

• First Year Infection Risk in SLE Patients Treated with Rituximab versus Standar…

SLE: Belimumab + standard rx significantly⬇️risk of severe flares vs placebo. Greatest in those with: 🔹+dsDNA 🔹low C3 or C4 🔹SLICC/ACR Damage index of 0 (argument for early treatment!) https://t.co/UcGXEklqwJ #ACR21 Abst#1295 @RheumNow

• Belimumab Reduces Severe Flares in Systemic Lupus Erythematosus Across Multiple…

Dr. Petri on SLE, Vit D, and BMD ~1k pts, 92% fem, 42% Black, 48% White Freq. of osteoporosis: 💠M ~ F 💠Black ~ White 💠⬆️in smokers Lumbar BMDs showed: 💠Vit D level w/Paradoxical effect 💠Rec goal of 40ng/mL in SLE https://t.co/kBylQAwqhD #ACR21 Abst#1265 #ACRBest @RheumNow

• Paradoxical Effect of Vitamin D on Bone Mineral Density in SLE - ACR Meeting Ab…

#ACR21 #Abstr1462 More case against Low dose Hydroxychloroquine as could ⬆️ risk of #lupus flares. Adjusted risk as below: Weight =>80kg, <400mg/d dose (OR 8.3) Weight <80kg, <300mg/d dose (OR 2.6) @RheumNow https://t.co/bTRMJDoSoI https://t.co/yzopiO3Kbo

• Hydroxychloroquine Dose and the Risk of Systemic Lupus Erythematosus Flares - A…

Post hoc analysis of BLISS-LN 🦋 Pts who didn't receive steroid pulses at induction 👇 🔸⬆ PERR & CRR responders, ⬇mean daily pred doses, more pts had ave daily pred <=5mg or <=7.5mg for both BEL & PBO 🔸BEL grp ⬇ flares/kidney-related death @RheumNow #ACR21 #ACRBest abs1461 https://t.co/ev0LK7d6oL