Excellent debate in #Lupus nephritis 6S214 with Wofsy, Isenberg & Costenbader. Q’s. What to do about Class V renal, many class III, IV LNdon’t go into sustained remission, cases of new onset LN in pts with #Belimumab ?more/less than expected, which drug to use @RheumNow #ACR21 https://t.co/tWbw79dE7d

Abs0266 #acr21 @RheumNow study of impact of pandemic on pts w/SLE (67%), RA (19%), & pSS (8%): 63%reported a flare since the pandemic & 16% had COVID-19. 19% reported no changes to their care.76% reported a change in their mood& emotional health. Was your pts experience similar?

In a newly diagnosed SLE patient with class IV nephritis, already on HCQ, in addition to GC's, would you... #ACR21 #GreatDebate @rheumnow #LupusNephritis

Secondary antiphospholipid syndrome (2APS) in SLE in Georgia Registry 👉12-14% of SLE pts 👉aCL 67%, LAC 51.5%, and aB2GP 7.7% 👉Inc rates of +dsDNA/Smith, livedo reticularis, serositis, & heme/renal/neuro d/o 👉⬇️rate in Black pts, but ⬆️thrombosis #ACR21 Abs 0078 @RheumNow

Lupus Nephritis in pregnancy: @HopkinsRheum Petri recommendations ⭐️AZA safe for LN, with tacro if needed ⭐️❌Voclosporin (alcohol content) ⭐️Belimumab uncertain @Rheumnow #ACR21 Great Debate

Dr. Eric Yen presenting about lupus nephritis mortality in the USA (1999-2019): - Increasing trend in LN mortality x5 yrs - Increased odds of death for Black pts > Latinx > API > AI/AN - Urbanization (large central metro area) independent RF + effect modifier #ACR21 https://t.co/qf61SkCqw4

#ACR21 #Abstr0456 How can we explain cognitive impairment in #lupus? Using f- and DCE-MRI, a study showed: 💠Abnormalities in brain functional connectivity 💠Extensive Blood-Brain Barrier leakage (BBB) BBB could be a future target @RheumNow https://t.co/KLeWfbQUQ0 https://t.co/ibNvBUWlMK

• Functional Connectivity, Enhanced Blood-Brain Barrier Leakage and Cognitive Imp…

So what’s interesting is that type I IFNs actually tighten the BBB. Is this dysfunctional in SLE? Or does this argue that CI does not correlate with SLE disease activity perhaps? #ACR21 #ACRAmbassador https://t.co/y5x2k3NQFi

• Dr. John Cush on Twitter: "Blood Brain Barrier leakage correlates w/ CNS d…

Why is lupus nephritis mortality trending up in the US, in contrast to overall SLE mortality? Race matters Urban location can make things worse I'm outside looking in but hope it's not too bold to say disparities affect whether you live or die from LN #ACR21 ABST0454 @RheumNow https://t.co/wmB9l9fFTT

SLE patients with +aPL was associated with: ➡️Nephritis ➡️Discoid rash ➡️Serositis ➡️Neurologic disorder Consider aPL and LAC status in patients w/these manifestations and whether anticoagulation/antiplatelets may be needed #ACR21 Abst#0077 @RheumNow

Lichenoid cutaneous lupus erythematosus mimicking acanthosis nigricans Regional Winner of Latin America and Caribbean Image Competition: Rheum Dz in Patients of Color #ACR21 @rheumnow https://t.co/4oAXIClwsm

#SLE pts have equal rates of post op CV events compared to TypeII DM pts and ⬆️ compared to matched controls. Esp driven by comorbidities. Should we add ASA post op in SLE pts with CV risks? #ACR21 #abst0128 @RheumNow https://t.co/COdbDxFgBQ

#ACR21 Abst#0454 Lupus nephritis mortality from 1999-2019 ⭐️-27% age-standardized mortality rate in LN death, though increased trend in last 5 yrs! ▶️ Afr-American 38% of deaths, though 12% of population (RR ~4.5), ⬆️mortality with urbanization https://t.co/fjeGXtItvD @RheumNow https://t.co/cE3t6lq8zi

• https://bit.ly/3CNsuEm

Yikes! Higher rates of lupus nephritis deaths in last 5 years 👉8900 lupus nephritis deaths in USA studied race/ethnicity and urbanization assc w/ LN mortality 👉highest in blacks and large central metro regions #ACR21 #Plenary Abstr# 0454 @rheumnow https://t.co/bxQvID8jht

Nice graphic presentation of the results! Dr. Katie Liao and her group present the characteristics and disease manifestations of Ro+ #SLE patients from the Australian #lupus registry and biobank @RheumNow #ACR21 abs0323 https://t.co/Yl5sZgiTw1